Patents by Inventor Bram ZOETEBIER

Bram ZOETEBIER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Porous affinity hydrogel particles for reducing the bioavailability of selected biological molecules
    Patent number: 11414483
    Abstract: A hydrogel particle that has an average cross-sectional diameter in the range from 1 micrometer (?m) to 1000 ?m, wherein the particle includes a first polymer network with an average mesh size that allows diffusion of a molecule with an hydrodynamic radius of 1000 nanometer (nm) or less into the first polymer network and which particle includes one or more binding molecules that are immobilized by the polymer network. The hydrogel particle preferably has wherein the first polymer network has an average mesh size that prevents diffusion of a molecule with an average hydrodynamic radius of more than 1000 nm to diffuse into the first polymer network, preferably the mesh size prevents diffusion of a molecule with an average hydrodynamic radius of more than 100 nm, and preferably more than 5 nm. Methods for reducing the bioavailability of one or more soluble biological molecules in a biological system by using the described hydrogel particle.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 16, 2022
    Assignee: HY2CARE B.V.
    Inventors: Tom Kamperman, Lisanne Paula Karbaat, Hermanus Bernadus Johannes Karperien, Jeroen Christianus Hermanus Leijten, Pieter Jelle Dijkstra, Bram Zoetebier
  • POROUS AFFINITY HYDROGEL PARTICLES FOR REDUCING THE BIOAVAILABILITY OF SELECTED BIOLOGICAL MOLECULES
    Publication number: 20200347125
    Abstract: A hydrogel particle that has an average cross-sectional diameter in the range from 1 micrometer (?m) to 1000 ?m, wherein the particle includes a first polymer network with an average mesh size that allows diffusion of a molecule with an hydrodynamic radius of 1000 nanometer (nm) or less into the first polymer network and which particle includes one or more binding molecules that are immobilized by the polymer network. The hydrogel particle preferably has wherein the first polymer network has an average mesh size that prevents diffusion of a molecule with an average hydrodynamic radius of more than 1000 nm to diffuse into the first polymer network, preferably the mesh size prevents diffusion of a molecule with an average hydrodynamic radius of more than 100 nm, and preferably more than 5 nm. Methods for reducing the bioavailability of one or more soluble biological molecules in a biological system by using the described hydrogel particle.
    Type: Application
    Filed: January 18, 2019
    Publication date: November 5, 2020
    Inventors: Tom KAMPERMAN, Lisanne Paula KARBAAT, Hermanus Bernadus Johannes KARPERIN, Jeroen Christianus Hermanus LEIJTEN, Pieter Jelle DIJKSTRA, Bram ZOETEBIER