Patents by Inventor Branko Stefanovic

Branko Stefanovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USING FLUORESCENT COLLAGEN .alpha. 1(I) AND .alpha. 2(I) mRNAs TO SCREEN DRUG CANDIDATES
    Publication number: 20230313296
    Abstract: Fluorescent collagen a1(I) and a2(I) mRNA compounds can be used to detect whether a test compound affects the binding of collagen a1(I) and/or a2(I) mRNAs to LARP6 protein. Fluorescent collagen a1(I) and a2(I) mRNA compounds include collagen a1(I) and a2(I) mRNA sequences that have been tagged with a fluorophore and have LARP6 binding affinity.
    Type: Application
    Filed: March 16, 2023
    Publication date: October 5, 2023
    Applicant: Florida State University Research Foundation, Inc.
    Inventor: Branko Stefanovic
  • PERSONALIZED MEDICAL DEVICE AND METHOD OF ITS PREPARATION
    Publication number: 20230130215
    Abstract: A personalized medical device intended for correction of defects, in particular in the orofacial area is multicomposite and comprises a hard tissue replacement and a soft tissue replacement. The hard tissue replacement is a hard core of biocompatible thermoplastic material and the soft tissue replacement is a biocompatible elastic substance. Preparation of personalized medical device even in the prenatal period using CT, MRI and 3D/4D electronic USG imaging and “additive manufacturing” technology.
    Type: Application
    Filed: February 12, 2021
    Publication date: April 27, 2023
    Inventors: Martin JUHAS, Josef Zivcak, Radovan Hudak, Marek Schnitzer, Branko Stefanovic
  • Compositions And Methods For Inhibiting Type 1 Collagen Production
    Publication number: 20230087749
    Abstract: This discloses that compounds of Formula 1 may be used as antifibrotics because they inhibit type 1 collagen production. In particular, this discloses a pharmaceutical composition containing one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
    Type: Application
    Filed: November 22, 2022
    Publication date: March 23, 2023
    Inventor: Branko Stefanovic
  • Antifibrotic Compounds And Related Methods
    Publication number: 20230090542
    Abstract: This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
    Type: Application
    Filed: November 22, 2022
    Publication date: March 23, 2023
    Inventors: Branko Stefanovic, Adel Nefzi
  • Compositions and methods for inhibiting type 1 collagen production
    Patent number: 11554121
    Abstract: This discloses that compounds of Formula 1 may be used as antifibrotics because they inhibit type 1 collagen production. In particular, this discloses a pharmaceutical composition containing one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: January 17, 2023
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Branko Stefanovic
  • Antifibrotic compounds and related methods
    Patent number: 11548874
    Abstract: This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: January 10, 2023
    Assignees: Florida State University Research Foundation, Inc., The Florida International University Board Of Trustees
    Inventors: Branko Stefanovic, Adel Nefzi
  • Antifibrotic Compounds And Related Methods
    Publication number: 20210363131
    Abstract: This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
    Type: Application
    Filed: May 13, 2021
    Publication date: November 25, 2021
    Inventors: Branko Stefanovic, Adel Nefzi
  • Compositions And Methods For Inhibiting Type 1 Collagen Production
    Publication number: 20210299136
    Abstract: This discloses that compounds of Formula 1 may be used as antifibrotics because they inhibit type 1 collagen production. In particular, this discloses a pharmaceutical composition containing one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.
    Type: Application
    Filed: March 30, 2021
    Publication date: September 30, 2021
    Inventor: Branko Stefanovic
  • Characterization of Type 1 Collagen Synthesis By Fluorescence Imaging and Related Drug Screening Technique
    Publication number: 20180188266
    Abstract: A method includes fluorescence imaging a cell that synthesizes Type 1 collagen. The cell includes a first gene encoding collagen a1(I) tagged with a first fluorescent tag and a second gene encoding collagen a2(I) tagged with a second fluorescent tag.
    Type: Application
    Filed: January 2, 2018
    Publication date: July 5, 2018
    Applicant: Florida State University Research Foundation, Inc.
    Inventor: Branko Stefanovic
  • Compositions and methods for inhibiting collagen production
    Patent number: 8729090
    Abstract: Embodiments of the invention include compositions effective for inhibiting collagen production and related methods. A preferred method comprises contacting at least one cell capable of producing collagen with a composition effective for inhibiting collagen production thereby. The composition comprises one or more of the compounds effective for inhibiting collagen production disclosed herein.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: May 20, 2014
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Branko Stefanovic
  • Protein controlling synthesis of collagen and associated methods
    Patent number: 8697385
    Abstract: A method of screening an agent for ability to interfere with collagen synthesis includes the steps of reacting a polypeptide having an amino acid sequence comprising SEQ ID NO: 1 with collagen mRNAs in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the mRNAs. Another method includes the steps of reacting the polypeptide with nonmuscle myosin filaments in the presence of the agent and detecting if the agent has interfered with binding of the polypeptide to the nonmuscle myosin filaments.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: April 15, 2014
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Branko Stefanovic