Patents by Inventor Brent Vernon

Brent Vernon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In situ forming hydrogel and method using same
    Patent number: 10780145
    Abstract: A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: September 22, 2020
    Assignees: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY, BANNER HEALTH
    Inventors: Derek Overstreet, Brent Vernon, Ryan McLemore, Alex McLaren
  • Injectable cell-laden biohybrid hydrogels for cardiac regeneration and related applications
    Patent number: 10265439
    Abstract: The present invention provides a temperature-responsive dual-gelling hydrogel comprising a plurality of hydrogel polymers and a polymer cross-linking moiety, wherein the LCST of the hydrogel polymers is less than 37° C., and the polymer cross-linking moiety is capable of chemically cross linking to the hydrogel polymers to form a polymer matrix.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: April 23, 2019
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Mehdi Nikkhah, Brent Vernon
  • IN SITU FORMING HYDROGEL AND METHOD USING SAME
    Publication number: 20180153956
    Abstract: A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 7, 2018
    Inventors: Derek Overstreet, Brent Vernon, Ryan McLemore, Alex McLaren
  • INJECTABLE CELL-LADEN BIOHYBRID HYDROGELS FOR CARDIAC REGENERATION AND RELATED APPLICATIONS
    Publication number: 20170065746
    Abstract: The present invention provides a temperature-responsive dual-gelling hydrogel comprising a plurality of hydrogel polymers and a polymer cross-linking moiety, wherein the LCST of the hydrogel polymers is less than 37° C., and the polymer cross-linking moiety is capable of chemically cross linking to the hydrogel polymers to form a polymer matrix.
    Type: Application
    Filed: August 19, 2016
    Publication date: March 9, 2017
    Inventors: Mehdi Nikkhah, Brent Vernon
  • Water-Stable Hydrogel and Method Using Same
    Publication number: 20140288189
    Abstract: A hydrogel (I) comprising a polymer backbone comprising a plurality of repeat units, wherein one or more of the repeat units comprises a pendent water soluble polymer attached thereto by a linkage selected from the group consisting of amide, thioamide, urea, and thiourea.
    Type: Application
    Filed: October 12, 2012
    Publication date: September 25, 2014
    Inventors: Derek Overstreet, Brent Vernon, Ryan McLemore
  • In Situ Forming Hydrogel and Method Using Same
    Publication number: 20140256617
    Abstract: A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.
    Type: Application
    Filed: October 12, 2012
    Publication date: September 11, 2014
    Inventors: Derek Overstreet, Brent Vernon, Ryan McLemore, Alex McLaren
  • In situ gelling self-reactive materials for embolization
    Patent number: 8048407
    Abstract: A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate through a catheter, whereby the composition crosslinks within the body to block or occlude the AVM.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: November 1, 2011
    Inventors: Brent Vernon, Merrill Birdno, Mark C. Preul
  • Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
    Patent number: 7744912
    Abstract: The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: June 29, 2010
    Assignees: Eidgenossische Technische Hochschule Zurich, Universitat Zurich
    Inventors: Jeffrey A. Hubbell, Donald Elbert, Matthias Lütolf, Alison Pratt, Ronald Schoenmakers, Nicola Tirelli, Brent Vernon
  • In situ gelling self-reactive materials for embolization
    Publication number: 20060263301
    Abstract: A method and composition for treating arteriovenous malformations (AVMs), or abnormal vasculature in the body are provided. The method comprises introducing into the region of an AVM a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate through a catheter, whereby the composition crosslinks within the body to block or occlude the AVM.
    Type: Application
    Filed: April 26, 2004
    Publication date: November 23, 2006
    Inventors: Brent Vernon, Merrill Birdno, Mark Preul
  • Method for sterilization using in situ gelling materials
    Publication number: 20060148897
    Abstract: A method for sterilizing a female or male patient is provided. The method comprises introducing into a reproductive duct of the patient a composition comprising a nucleophilic component, such as a thiol, and a component containing a conjugated unsaturated bond, such as an acrylate. The composition crosslinks within the reproductive duct. Within a female patient, the composition is introduced into one or both uterine tubes. The composition gels in the uterine tubes, thereby blocking the uterine tubes and preventing conception.
    Type: Application
    Filed: September 15, 2003
    Publication date: July 6, 2006
    Inventors: Brent Vernon, Kelly Roy
  • Localized delivery system for cancer drugs, phenstatin, using N-isopropylacrylamide
    Publication number: 20040052761
    Abstract: An injectable drug delivery system for localized release of Phenstatin to a tumor site over a period of time is provided. The drug delivery system comprises the thermoresponsive polymer N-isopropylacrylamide (NIPAAM) and Phenstatin, a toxic antineoplastic agent. The drug delivery system has a critical solution temperature (LCST) that causes it to change from the liquid state at room temperature when injected to a gel or semi-solid state after reaching the temperature of the human body in situ.
    Type: Application
    Filed: July 21, 2003
    Publication date: March 18, 2004
    Inventors: Brent Vernon, Steven Powell