Abstract: In one non-limiting aspect, the invention provides a method for detecting the quality of a biological molecule comprising forming a first mixture of ingredients comprising: (i) a first binding agent that specifically binds to a tag, wherein the first binding agent is attached to a solid support; (ii) a decoy comprising a first portion comprising the tag attached to a second portion comprising an anchor; (iii) a sensor attached to a second binding agent that specifically binds to the anchor; and (iv) a sample suspected of containing a high quality biological molecule comprising a tag, wherein the tag of the high quality biological molecule is accessible; allowing interaction of the ingredients such that the sensor provides an output signal.

Abstract: Provided are methods and kits for analyzing biomarkers in one or more signal transduction pathways in a cell. In some embodiments, the methods and kits of the invention permit simultaneous analysis of more than one biomarker and/or more than one signal transduction pathway. In some embodiments, the invention provides methods for detecting whether a cell treated with an agent targeting a targeted biomarker is responding to the agent, or whether the cell is developing resistance to the agent. In some embodiments, the invention provides methods for determining which biomarker to target in a diseased or damaged cell, or which pathway an agent is targeting in an agent-treated cell. The invention provides kits for carrying out the described methods.

Abstract: In one non-limiting aspect, the invention provides a method for detecting the quality of a biological molecule comprising forming a first mixture of ingredients comprising: (i) a first binding agent that specifically binds to a tag, wherein the first binding agent is attached to a solid support; (ii) a decoy comprising a first portion comprising the tag attached to a second portion comprising an anchor; (iii) a sensor attached to a second binding agent that specifically binds to the anchor; and (iv) a sample suspected of containing a high quality biological molecule comprising a tag, wherein the tag of the high quality biological molecule is accessible; allowing interaction of the ingredients such that the sensor provides an output signal

Abstract: An improved spark ignition system. Pressure on a piezoelectric element results in a voltage that, when discharged across a spark gap, causes dielectric breakdown in a fuel air mixture. Additional current to power combustion is supplied by a capacitor circuit. The ignition system increases the combustion rate and decreases emissions of NOx.

Abstract: A method and device for hanging elevator pads. An elevator pad clamp is disclosed that includes a back plate having an attachment end for holding the back plate in relation to an elevator wall and having two wing segments extending away from a surface of the back plate. A clamp plate is hinged to the wing segments at a clamp axis, and a spring is hinged to the wing segments and positioned to bias the clamp plate in a first state. A lever portion is hinged to the wing segments at a lever axis. The lever portion has an urging member shaped to urge against a first surface of the clamp plate as the lever portion is rotated about the lever axis to cause the clamp plate to rotate about the clamp axis. The clamping device has two states. In an open state the clamp plate and the back plate define an open set of elevator-pad receiving jaws. The device may remain in the open state without depressing the lever. In a closed state, the jaws are closed and locked.