Patents by Inventor Brian A. Bucher
Brian A. Bucher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9926287Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: November 18, 2016Date of Patent: March 27, 2018Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Publication number: 20170066734Abstract: A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: November 18, 2016Publication date: March 9, 2017Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Patent number: 9527825Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: GrantFiled: February 25, 2016Date of Patent: December 27, 2016Assignee: Phyton Holdings, LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
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Publication number: 20160176837Abstract: Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.Type: ApplicationFiled: February 25, 2016Publication date: June 23, 2016Inventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James H. Johnson, John S. Juchum, Marc A. Plante, T.G. Sambandam, Dong S. Yang
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Patent number: 9303004Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 24, 2014Date of Patent: April 5, 2016Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20150005517Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 24, 2014Publication date: January 1, 2015Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Patent number: 8703982Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: GrantFiled: February 12, 2010Date of Patent: April 22, 2014Assignee: Phyton Holdings LLCInventors: Brian A. Bucher, Edward M. Desimone, III, Roland R. Franke, Rex T. Gallagher, Barry J. Hand, Christopher D. Howe, James A. Johnson, John S. Juchum, Marc A. Plante, T. G. Sambandam, Dong S. Yang
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Patent number: 7897796Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: June 18, 2007Date of Patent: March 1, 2011Assignee: Phyton Holdings, LLCInventors: James H. Johnson, T. G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20100145080Abstract: Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.Type: ApplicationFiled: February 12, 2010Publication date: June 10, 2010Applicant: Phyton Holdings LLCInventors: James H. Johnson, T.G. Sambandam, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plante, Edward M. Desimone, III, Dong S. Yang
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Publication number: 20080076936Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: ApplicationFiled: June 18, 2007Publication date: March 27, 2008Inventors: James Johnson, T.G. Sambandam, Barry Hand, Christopher Howe, Roland Franke, Brian Bucher, John Juchum, Rex Gallagher, Marc Plante, Edward Desimone, Dong Yang
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Publication number: 20060127510Abstract: A process for harvesting yew biomass and a process of making Yew pellets from Yew tree material is disclosed herein. The process for harvesting comprising the steps of (i) harvesting the tops or roots of the Yew tree; (ii) washing the harvested material; (iii) drying the harvested material; and (iv) grinding the harvested material into a fine powder. The process for making Yew pellets comprising the steps of (i) adding from about 1% to about 20% w/w water to the Yew tree material; and (ii) compressing the Yew tree material in a die to form a pellet whereby the resulting pellet has a final moisture content of less than 10% by weight. The yew pellets produced herein are suitable for extracting taxane molecules from the pellets.Type: ApplicationFiled: June 30, 2005Publication date: June 15, 2006Inventors: Rex Gallagher, Christopher Howe, Edward Desimone, Brian Bucher, Barry Hand, Steven Perich, Michael Aeschliman, Ivan Wyse
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Patent number: 6956123Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: GrantFiled: September 18, 2003Date of Patent: October 18, 2005Assignee: Natural Pharmaccuticals, Inc.Inventors: James H. Johnson, T. G. Sambandan, Barry J. Haad, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Juchum, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, III, Dong S. Yang
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Publication number: 20040186305Abstract: This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.Type: ApplicationFiled: September 18, 2003Publication date: September 23, 2004Inventors: James H. Johnson, T.G. Sambandan, Barry J. Hand, Christopher D. Howe, Roland R. Franke, Brian A. Bucher, John S. Jucham, Rex T. Gallagher, Marc A. Plant, Edward M. De Simone, Dong S. Yang