Patents by Inventor Brian A. Crowe

Brian A. Crowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11957520
    Abstract: A surgical headlamp assembly which can be remotely actuated at a wearer's chest and is suitable for surgical applications may include a headpiece. The headpiece may be sizable and configurable for placement on the head of a wearer. A lamp may be provided on the headpiece. The lamp may include at least one light source. At least one battery may be provided on the headpiece. The lamp may electrically interface with the battery. A remote lamp control module may operationally interface with the battery and the lamp. The lamp control module may be configured to control emission of a light beam from the lamp. The remote lamp control module may be suspendable from the headpiece and deployable in front of the chest of the wearer. In typical application of the surgical headlamp assembly, the lamp control module may be worn on the chest of the wearer.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: April 16, 2024
    Inventors: Brian Crowe, Ryan Pizinger
  • Patent number: 11305000
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: April 19, 2022
    Assignees: Brookhaven Science Associates, LLC, The Research Foundation of State University of New York, Baxalta Incorporated, Baxalta GmbH
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Publication number: 20180296656
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: January 19, 2018
    Publication date: October 18, 2018
    Applicants: BROOKHAVEN SCIENCE ASSOCIATE, LLC, RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK
    Inventors: Brian A. Crowe, Ian Livey, Maria O'rourke, Michael Schwendinger, John J Dunn, Benjamin J Luft
  • Patent number: 9895434
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: February 20, 2018
    Assignees: Research Foundation of the State University of New York, Brookhaven Science Associates, LLC
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Publication number: 20160235830
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: February 22, 2016
    Publication date: August 18, 2016
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Patent number: 9334311
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: May 10, 2016
    Assignees: BAXALTA INCORPORATED, BAXALTA GMBH
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger
  • Patent number: 9303073
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: April 5, 2016
    Assignees: BAXALTA INCORPORATED, BAXALTA GMBH, Research Foundation of the State University of New York, Brookhaven Science Associates, LLC
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Patent number: 9023367
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: May 5, 2015
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: P. Noel Barrett, Gerald Aichinger, Brian A. Crowe, Ian Livey, Nina Wressnigg
  • Publication number: 20140141030
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 22, 2014
    Applicants: BAXTER INTERNATIONAL INC., Brookhaven Science Associates, LLC, Research Foundation of the State University of New York, BAXTER HEALTHCARE SA
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Publication number: 20140141029
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 22, 2014
    Applicants: BAXTER HEALTHCARE SA, BAXTER INTERNATIONAL INC.
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger
  • Publication number: 20140030284
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: July 11, 2013
    Publication date: January 30, 2014
    Applicants: BAXTER HEALTHCARE SA, BAXTER INTERNATIONAL INC.
    Inventors: P. Noel Barrett, Gerald Aichinger, Brian A. Crowe, Ian Livey, Nina Wressnigg
  • Patent number: 8623376
    Abstract: The invention relates to the development of chimeric OpsA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: January 7, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A., Research Foundation for the State University of New York, Brookhaven Science Associates, LLC
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Patent number: 8623375
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: January 7, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger
  • Publication number: 20120020973
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: May 13, 2011
    Publication date: January 26, 2012
    Applicants: BAXTER INTERNATIONAL INC., Brookhaven Sciences Associates, LLC, Research Foundation of the State University of New York, BAXTER HEALTHCARE S.A.
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
  • Publication number: 20110293652
    Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.
    Type: Application
    Filed: May 13, 2011
    Publication date: December 1, 2011
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger
  • Patent number: 6872550
    Abstract: A novel approach to Borrelia vaccine formulation taking into account serological, genotypic and epidemiological information by which OspC proteins from different strains of B. burgdorferi are grouped together. OspC antigens are chosen in order to constitute a representative sample of such groupings, so that the resulting vaccine provides the greatest cross-protectivity with the fewest number of antigens.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: March 29, 2005
    Assignee: Baxter Vaccine AG
    Inventors: Ian Livey, Brian Crowe, Friedrich Dorner
  • Patent number: 6654802
    Abstract: A system and method for continuously monitoring neighboring network elements and determining physical connection topology and changes in topology among network elements. Each port in a network element capable of having physical connectivity to a port on an adjacent network element has a unique identification of the node and a unique identification of the port. The identification is both available to the network management system and continuously transmitted on the physical link between two ports in the network, thus identifying the transmitting port to the receiving port. As nodes and ports are added to or deleted from a network, a representation of the nodes or ports is added or removed from the network management system. The local operating program in each network element informs the network management system of changes, or changes are queried by a network management system.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: November 25, 2003
    Assignee: Sprint Communications Company, L.P.
    Inventors: Stephen Arthur Oliva, Brian Crowe
  • Patent number: 6486130
    Abstract: A novel approach to Borrelia vaccine formulation taking into account serological, genotypic and epidemiological information by which OspC proteins from different strains of B burgdorferi are grouped together. OspC antigens are chosen in order to constitute a representative sample of such groupings, so that the resulting vaccine provides the greatest cross-protectivity with the fewest number of antigens.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: November 26, 2002
    Assignee: Baxter Vaccine AG
    Inventors: Ian Livey, Brian Crowe, Friedrich Dorner
  • Patent number: 6261629
    Abstract: Novel water-soluble free-flowing protein-fibre products are provided from cereal grains, such as wheat, free from starch, bran and low molecular weight degradation products thereof. Starch contaminants in soluble fractions of the cereal grains are removed by enzymatic degradation and separation. The protein to fibre ratio of the product may be modified by enzymatic treatment. Such materials are useful in a wide variety of food application.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: July 17, 2001
    Inventors: Giuseppe Mazza, Lei Gao, B. Dave Oomah, Donald O'Connor, Brian Crowe