Patents by Inventor Brian A. Zabel

Brian A. Zabel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11938193
    Abstract: The present disclosure provides compositions comprising chemerin and the methods of use thereof. The compositions of the disclosure are useful in the treatment of cancer.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: March 26, 2024
    Assignee: Washington University
    Inventors: Russell Pachynski, Holbrook Kohrt, Jason Yonehiro, Brian Zabel
  • Publication number: 20240075155
    Abstract: The present disclosure provides compositions comprising chemerin and the methods of use thereof. The compositions of the disclosure are useful in the treatment of cancer.
    Type: Application
    Filed: May 2, 2023
    Publication date: March 7, 2024
    Inventors: Russell Pachynski, Holbrook Kohrt, Jason Yonehiro, Brian Zabel
  • Publication number: 20230340123
    Abstract: The invention provides novel anti-BTLA antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
    Type: Application
    Filed: July 10, 2022
    Publication date: October 26, 2023
    Inventors: Brian A. ZABEL, John A. LIPPINCOTT, Yayue ZHENG, Megha Vaman RAO, Miao TAN, David P. MEININGER
  • Patent number: 11730705
    Abstract: ?-NETA analogs are provided for the treatment of inflammatory disease.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: August 22, 2023
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States Government As Represented By The Department of Veterans Affairs
    Inventors: Sanjay Malhotra, Vineet Kumar, Melissa LaJevic, Mallesh Pandrala, Brian A. Zabel
  • Publication number: 20230115257
    Abstract: Embodiments include monoclonal antibodies (mAbs) that recognize SARS-Cov-2 spike protein. The mAbs are capable of distinguishing among variants of the virus. The present disclosure also provides a composition and methods of making and using such a composition for treating, preventing, and/or detecting SARS-CoV-2 infection.
    Type: Application
    Filed: May 17, 2022
    Publication date: April 13, 2023
    Inventors: Brian A. ZABEL, Dan LUO, Ling ZHANG, Vydehi KANNEGANTI, Joyce YU, Sophie YANG, Lequn ZHAO, Hua TU, Xiaomei GE
  • Publication number: 20220372114
    Abstract: The present disclosure provides antibodies that bind to the SARS-CoV-2 spike protein, as well as compositions containing the same, and methods of making and using such a composition for treating, preventing, and/or detecting SARS-CoV-2 infection.
    Type: Application
    Filed: May 17, 2022
    Publication date: November 24, 2022
    Inventors: Brian A. ZABEL, Dan LUO, Ling ZHANG, Vydehi KANNEGANTI, Joyce YU, Sophie YANG, Lequn ZHAO, Hua TU
  • Patent number: 11421875
    Abstract: A burner control system for improving burner performance and efficiency may determine fuel and air channel or manifold parameters. Determination of parameters may be performed with a sensor connected across the air and fuel channels. A signal from the sensor may control the parameters which in turn affect the amounts of fuel and air to the burner via a controller. Parameter control of the fuel and air in their respective channels may result in more accurate fuel and air ratio control. One or more flow restrictors in fuel and/or air bypass channels may further improve accuracy of the fuel and air ratio. The channels may be interconnected with a pressure or flow divider. Byproducts of combustion in the exhaust, temperatures of gas and air, flame quality and/or other items may be monitored and adjusted with control of the fuel and air ratio for optimum combustion in the burner.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: August 23, 2022
    Assignee: HONEYWELL INTERNATIONAL INC.
    Inventors: Gregory Young, David Kucera, Donald J. Kasprzyk, Willem Super, Jos Praat, Roelof Thiewes, Hans M. van der Mei, Brian Zabel, John D. Mitchell
  • Patent number: 11384146
    Abstract: The invention provides novel anti-BTLA antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: July 12, 2022
    Assignees: Curia IP Holdings, LLC, TRIANNI, Inc.
    Inventors: Brian A. Zabel, John A. Lippincott, Yayue Zheng, Megha Vaman Rao, Miao Tan, David P. Meininger
  • Publication number: 20200345661
    Abstract: ?-NETA analogs are provided for the treatment of inflammatory disease.
    Type: Application
    Filed: April 13, 2020
    Publication date: November 5, 2020
    Inventors: Sanjay Malhotra, Vineet Kumar, Melissa LaJevic, Mallesh Pandrala, Brian A. Zabel
  • Publication number: 20200325230
    Abstract: The invention provides novel anti-BTLA antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
    Type: Application
    Filed: March 31, 2020
    Publication date: October 15, 2020
    Inventors: Brian A. Zabel, John A. Lippincott, Yayue Zheng, Megha Vaman Rao, Miao Tan, David P. Meininger
  • Patent number: 10739192
    Abstract: A controller unit for controlling an ultraviolet (UV) sensor may be excited by an excitation voltage that enables the UV sensor to detect incoming UV light. The UV sensor may provide UV detection events that may be related to the intensity of the incoming UV light. The control unit may include an excitation voltage generator, an event detector, and a controller configured to cause the excitation voltage generator to produce an excitation voltage for a cumulative excitation time that is less than 50% of the time, which may significantly increase the operational lifetime and/or reliability of a UV sensor.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: August 11, 2020
    Assignee: Honeywell International Inc.
    Inventors: Brian Zabel, Chad Carty, Aaron Daniels
  • Patent number: 10648857
    Abstract: A programmable controller for controlling an ultraviolet (UV) sensor may adjust an excitation voltage provided to the UV sensor based at least in part on a programmable sensitivity offset in order to produce an excitation voltage that results in a desired UV sensitivity for the UV sensor. The programmable sensitivity offset may be set for the UV sensor at the factory, set during commissioning of the UV sensor in the field, and/or automatically altered over time to help compensate for a degradation in sensitivity of the UV sensor.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: May 12, 2020
    Assignee: Honeywell International Inc.
    Inventors: Brian Zabel, Chad Carty, Aaron Daniels
  • Publication number: 20190376688
    Abstract: A burner control system for improving burner performance and efficiency. The system may determine fuel and air channel or manifold parameters. Determination of parameters may be performed with a sensor connected across the air and fuel channels. A signal from the sensor may control the parameters which in turn affect the amounts of fuel and air to the burner via a controller. Parameter control of the fuel and air in their respective channels may result in more accurate fuel and air ratio control. One or more flow restrictors in fuel and/or air bypass channels may further improve accuracy of the fuel and air ratio. The channels may be interconnected with a pressure or flow divider. Byproducts of combustion in the exhaust, temperatures of gas and air, flame quality and/or other items may be monitored and adjusted with control of the fuel and air ratio for optimum combustion in the burner.
    Type: Application
    Filed: August 22, 2019
    Publication date: December 12, 2019
    Applicant: Honeywell International Inc.
    Inventors: Gregory Young, David Kucera, Donald J. Kasprzyk, Willem Super, Jos Praat, Roelof Thiewes, Hans M. van der Mei, Brian Zabel, John D. Mitchell
  • Publication number: 20190310131
    Abstract: A programmable controller for controlling an ultraviolet (UV) sensor may adjust an excitation voltage provided to the UV sensor based at least in part on a programmable sensitivity offset in order to produce an excitation voltage that results in a desired UV sensitivity for the UV sensor. The programmable sensitivity offset may be set for the UV sensor at the factory, set during commissioning of the UV sensor in the field, and/or automatically altered over time to help compensate for a degradation in sensitivity of the UV sensor.
    Type: Application
    Filed: April 10, 2018
    Publication date: October 10, 2019
    Inventors: Brian Zabel, Chad Carty, Aaron Daniels
  • Publication number: 20190008982
    Abstract: The present disclosure provides compositions comprising chemerin and the methods of use thereof. The compositions of the disclosure are useful in the treatment of cancer.
    Type: Application
    Filed: January 9, 2017
    Publication date: January 10, 2019
    Inventors: Russell PACHYNSKI, Holbrook KOHRT, Jason YONEHIRO, Brian ZABEL
  • Patent number: 9976896
    Abstract: Utilizing a quench time to deionize an ultraviolet (UV) sensor tube are described herein. One method includes monitoring firing events within a UV sensor tube, where a particular firing event initiates arming the UV sensor tube, initiating a quench time to deionize the UV sensor tube, where the quench time includes, disarming the UV sensor tube to prevent a firing event.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: May 22, 2018
    Assignee: Honeywell International Inc.
    Inventors: Brian Zabel, Chad Carty, Barrett E. Cole
  • Patent number: 9868792
    Abstract: Chemerin is a chemoattractant that selectively directs intra-tumor recruitment of CMKLR1+ cells. Blockade of CCRL2 from binding to chemerin in non-neoplastic tumor cells, e.g. peri-tumor stromal and/or hematopoietic cells allows for redistribution of chemerin into the tumor and enhanced responsiveness against a tumor.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: January 16, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Zabel, Eugene C. Butcher, Russell K. Pachynski, Justin Monnier
  • Patent number: 9863990
    Abstract: Methods, devices, and systems for determining failure of an ultraviolet (UV) sensor are described herein. One device includes a memory, and a processor configured to execute executable instructions stored in the memory to reduce an excitation voltage of a UV sensor until no conduction occurs in the UV sensor, increase, upon no conduction occurring in the UV sensor, the excitation voltage of the UV sensor until a conduction event occurs, compare the excitation voltage at which the conduction event occurs to a reference voltage, and determine whether the UV sensor has failed based on the comparison.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: January 9, 2018
    Assignee: Honeywell International Inc.
    Inventors: Brian Zabel, Chad Carty
  • Patent number: 9657946
    Abstract: A burner control system for improving burner performance and efficiency. The system may determine fuel and air channel or manifold parameters. Determination of parameters may be performed with a sensor connected across the air and fuel channels. A signal from the sensor may control the parameters which in turn affect the amounts of fuel and air to the burner via a controller. Parameter control of the fuel and air in their respective channels may result in more accurate fuel and air ratio control. One or more flow restrictors in fuel and/or air bypass channels may further improve accuracy of the fuel and air ratio. The channels may be interconnected with a pressure or flow divider. Byproducts of combustion in the exhaust, temperatures of gas and air, flame quality and/or other items may be monitored and adjusted with control of the fuel and air ratio for optimum combustion in the burner.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: May 23, 2017
    Assignee: Honeywell International Inc.
    Inventors: Gregory Young, David Kucera, Donald J. Kasprzyk, Willem Super, Jos Praat, Roelof Thiewes, Hans M. van der Mei, Brian Zabel, John D. Mitchell
  • Publication number: 20170002087
    Abstract: Chemerin is a chemoattractant that selectively directs intra-tumor recruitment of CMKLR1+ cells. Blockade of CCRL2 from binding to chemerin in non-neoplastic tumor cells, e.g. peri-tumor stromal and/or hematopoietic cells allows for redistribution of chemerin into the tumor and enhanced responsiveness against a tumor.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Brian A. Zabel, Eugene C. Butcher, Russell K. Pachynski, Justin Monnier