Patents by Inventor Brian Broadbelt

Brian Broadbelt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of substituted urea compounds
    Patent number: 9458111
    Abstract: A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof: the process comprising the reaction of a carbamate of Formula (II?): Formula (I?): with a primary or secondary amine of the formula R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: October 4, 2016
    Assignee: BIAL—PORTELA & CA, S.A.
    Inventors: David Alexander Learmonth, Brian Broadbelt, Jorge Bruno Reis Wahnon
  • Crystalline forms and processes for their preparation
    Patent number: 8865913
    Abstract: The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: October 21, 2014
    Assignee: Bial-Portela & CA, S.A.
    Inventors: Alexander Beliaev, David Alexander Learmonth, Brian Broadbelt, Ekaterina Albert, Patricia Andres
  • Crystalline Forms and Processes for Their Preparation
    Publication number: 20140031561
    Abstract: The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine.
    Type: Application
    Filed: June 19, 2013
    Publication date: January 30, 2014
    Inventors: Alexander BELIAEV, David Alexander LEARMONTH, Brian BROADBELT, Ekaterina ALBERT, Patricia ANDRES
  • PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS
    Publication number: 20130123493
    Abstract: A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof, Formula (II): Formula (I): the process comprising the reaction of a carbamate of Formula (II?): or formula (I?): with a primary or secondary amine of the formula: R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.
    Type: Application
    Filed: July 28, 2011
    Publication date: May 16, 2013
    Applicant: BIAL - PORTELA & CA, S.A.
    Inventors: David Alexander Learmonth, Brian Broadbelt, Jorge Bruno Reis Wahnon
  • Process for the Preparation of 2H-Chromene-3-Carbamate Derivatives
    Publication number: 20100298580
    Abstract: Compounds of formula I, V, VI and II, and processes for their preparation, wherein R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R4 is alkyl or aryl. There is also provided a process for preparing a compound of formula B from the compounds of formula V and I.
    Type: Application
    Filed: November 13, 2008
    Publication date: November 25, 2010
    Applicant: BIAL - PORTELA & CA, S.A.
    Inventors: Brian Broadbelt, Alexander Beliaev, David Alexander Learmonth