Patents by Inventor Brian Cali

Brian Cali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Useful indole compounds
    Publication number: 20070203209
    Abstract: Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.
    Type: Application
    Filed: August 18, 2006
    Publication date: August 30, 2007
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Jing Yang, Craig Zimmerman, Alex Monreal
  • Modulators of CRTH2 Activity
    Publication number: 20070161698
    Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
    Type: Application
    Filed: March 13, 2007
    Publication date: July 12, 2007
    Inventors: Yueh-Tyng Chien, G. Milne, Mark Currie, John Talley, Brian Cali, Barbara Chen, Craig Zimmerman, Jing Yang
  • Methods for improving secondary metabolite production of fungi
    Publication number: 20060263864
    Abstract: Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.
    Type: Application
    Filed: December 3, 2002
    Publication date: November 23, 2006
    Inventors: Robert Busby, Brian Cali, Peter Hecht, Douglas Holtzman, Kevin Madden, Mary Maxon, G. Milne, Thea Norman, John Royer, Jeff Silva, Eric Summers, Lixin Zhang, Maria Mayorga, Toby Feibelman, Reed Doten
  • Modulators of FAAH
    Publication number: 20060167075
    Abstract: Methods for inhibiting the activity of FAAH and methods for preventing and/or treating certain disorders, e.g., anxiety disorders, sleep disorders and weight disorders, by administering celecoxib, valdecoxib or certain structurally related compounds at a dosage that is sufficient to treat and/or prevent the disorder are described.
    Type: Application
    Filed: January 25, 2006
    Publication date: July 27, 2006
    Inventors: James Pearson, G. Milne, Mark Currie, Brian Cali, John Talley
  • Modulators of CRTH2 activity
    Publication number: 20060135591
    Abstract: Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
    Type: Application
    Filed: July 18, 2005
    Publication date: June 22, 2006
    Inventors: Yueh-Tyng Chien, G. Milne, Mark Currie, John Talley, Brian Cali, Barbara Chen, Craig Zimmerman, Jing Yang
  • Modulators of CRTH2, COX-2 and FAAH
    Publication number: 20050234030
    Abstract: Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.
    Type: Application
    Filed: January 3, 2005
    Publication date: October 20, 2005
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Jing Yang, Craig Zimmerman
  • Synthesis of COX-2 and FAAH inhibitors
    Publication number: 20050234244
    Abstract: Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.
    Type: Application
    Filed: November 1, 2004
    Publication date: October 20, 2005
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Craig Zimmerman
  • Methods for improving secondary metabolite production in fungi
    Patent number: 6949356
    Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: September 27, 2005
    Assignee: Microbia, Inc.
    Inventors: Robert Busby, Brian Cali, Peter Hecht, Doug Holtzman, Kevin Madden, Mary Maxon, Todd Milne, Thea Norman, John Royer, Sofie Salama, Amir Sherman, Jeff Silva, Eric Summers
  • Novel regulators of fungal gene expression
    Publication number: 20050095633
    Abstract: The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
    Type: Application
    Filed: September 28, 2004
    Publication date: May 5, 2005
    Inventors: Brian Cali, Douglas Holtzman, Jeffrey Silva, Joshua Trueheart, Lixin Zhang, Kevin Madden, G. Milne, Amir Sherman
  • COX-2 and FAAH inhibitors
    Publication number: 20050032747
    Abstract: The invention features compounds that inhibit COX-2 and/or FAAH. The COX-2 inhibitors are selective COX-2 inhibitors in that they are selective for COX-2 compared to COX-1. Certain of the FAAH inhibitors are selective for FAAH relative to COX-2. Certain of the COX-2 inhibitors, in addition for being selective for COX-2 relative to COX-1, are selective for COX-2 relative to FAAH.
    Type: Application
    Filed: July 1, 2004
    Publication date: February 10, 2005
    Inventors: Wilmin Bartolini, Brian Cali, Barbara Chen, Yueh-Tyng Chien, Mark Currie, G. Milne, James Pearson, John Talley, Craig Zimmerman
  • Methods for the protection of memory and cognition
    Publication number: 20050004104
    Abstract: The invention features certain compounds useful in the treatment of memory disorders, i.e., they reduce or delay memory loss or they enhance memory retention. Because certain of the compounds do not substantially inhibit either COX-1 or COX-2 at therapeutically relevant doses, these compounds are far less likely to cause gastrointestinal ulceration than is indomethacin, which is known to inhibit both COX-1 and COX-2. Certain of the compounds inhibit the activity of DAO at therapeutically relevant doses. Among the memory disorders that can be treated are AD, mild cognitive impairment (MCI; a common precursor to AD), and memory loss or cognitive impairment associated with vascular dementias, amnesia, dementia, AIDS dementia, Huntington's Disease, hydrocephalus, depression, Pick's Disease, Creutzfeldt-Jakob Syndrome, electroconvulsive therapy, or Parkinson's Disease.
    Type: Application
    Filed: June 1, 2004
    Publication date: January 6, 2005
    Inventors: Brian Cali, Yueh-Tyng Chien, Mark Currie, John Talley, Craig Zimmerman
  • Regulation of fungal gene expression
    Publication number: 20030235857
    Abstract: Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.
    Type: Application
    Filed: June 4, 2003
    Publication date: December 25, 2003
    Applicant: Whitehead Institute for BioMedical Research, a Delaware corporation
    Inventors: Steffen Rupp, Laura Robertson, Eric F. Summers, Peter Hecht, Radclyffe Roberts, Hiten Madhani, Cora Ann Styles, Hsiu-Jung Lo, Amir Sherman, Brian Cali, Gerald R. Fink
  • Use of sublethal concentrations of anti-invasin compounds to therapeutically or prophylactically treat fungal infections
    Publication number: 20030176367
    Abstract: The invention relates to the therapeutic or prophylactic treatment of fungal infections. The invention provides new methods for therapeutically or prophylactically treating fungal infections using sub-lethal concentrations of an anti-invasin compound. The methods according to the invention have fewer toxicology problems than existing methods, and thus can be used prophylactically, as well as for early treatment for high risk patients without a firm diagnosis. The methods according to the invention can also be used to treat an established fungal infection. The invention further provides novel genes that regulate fungal hyphal growth.
    Type: Application
    Filed: October 21, 2002
    Publication date: September 18, 2003
    Applicant: Microbia, Inc. a Delaware Corportion
    Inventors: Brian Cali, Etchell Cordero, Peter Hecht, G. Todd Milne, Sofie Salama, Eric Summers, Joshua Trueheart
  • Regulation of fungal gene expression
    Patent number: 6599705
    Abstract: Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: July 29, 2003
    Assignee: The Whitehead Institute for Biomedical Research
    Inventors: Steffen Rupp, Laura Robertson, Eric F. Summers, Peter Hecht, Radclyffe Roberts, Hiten Madhani, Cora Ann Styles, Hsiu-Jung Lo, Amir Sherman, Brian Cali, Gerald R. Fink
  • Regulation of fungal gene expression
    Publication number: 20020155517
    Abstract: Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.
    Type: Application
    Filed: May 22, 2001
    Publication date: October 24, 2002
    Inventors: Steffen Rupp, Laura Robertson, Eric F. Summers, Peter Hecht, Radclyffe Roberts, Hiten Madhani, Cora Ann Styles, Hsiu-Jung Lo, Amir Sherman, Brian Cali, Gerald R. Fink
  • Methods for improving secondary metabolite production in fungi
    Publication number: 20020128250
    Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
    Type: Application
    Filed: March 7, 2001
    Publication date: September 12, 2002
    Inventors: Robert Busby, Brian Cali, Peter Hecht, Doug Holtzman, Kevin Madden, Mary Maxon, Todd Milne, Thea Norman, John Royer, Sofie Salama, Amir Sherman, Jeff Silva, Eric Summers
  • Regulation of fungal gene expression
    Patent number: 6303302
    Abstract: Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.
    Type: Grant
    Filed: November 10, 1998
    Date of Patent: October 16, 2001
    Assignee: The Whitehead Institute for Biomedical Research
    Inventors: Steffen Rupp, Laura Robertson, Eric F. Summers, Peter Hecht, Radclyffe Roberts, Hiten Madhani, Cora Ann Styles, Hsiu-Jung Lo, Amir Sherman, Brian Cali, Gerald L. Fink