Patents by Inventor Brian Campbell Wilson
Brian Campbell Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240148291Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared.Type: ApplicationFiled: January 1, 2024Publication date: May 9, 2024Inventors: Pablo Valdes, Frederic Leblond, Keith D. Paulsen, Brian Campbell Wilson, David W. Roberts, Michael Jermyn
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Patent number: 11857317Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared.Type: GrantFiled: October 6, 2022Date of Patent: January 2, 2024Assignees: THE TRUSTEES OF DARTMOUTH COLLEGE, UNIVERSITY HEALTH NETWORKInventors: Pablo Valdes, Frederic Leblond, Keith D. Paulsen, Brian Campbell Wilson, David W. Roberts, Michael Jermyn
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Patent number: 11690514Abstract: Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.Type: GrantFiled: December 23, 2019Date of Patent: July 4, 2023Assignee: University Health NetworkInventors: Anthony Taywon Kim, Brian Campbell Wilson
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Publication number: 20230075997Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared.Type: ApplicationFiled: October 6, 2022Publication date: March 9, 2023Inventors: Pablo Valdes, Frederic Leblond, Keith D. Paulsen, Brian Campbell Wilson, David W. Roberts, Michael Jermyn
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Patent number: 11510600Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared.Type: GrantFiled: February 15, 2016Date of Patent: November 29, 2022Assignee: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Pablo Valdes, Frederic Leblond, Keith D. Paulsen, Brian Campbell Wilson, David W. Roberts, Michael Jermyn
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Publication number: 20200155004Abstract: Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.Type: ApplicationFiled: December 23, 2019Publication date: May 21, 2020Applicant: University Health NetworkInventors: Anthony Taywon Kim, Brian Campbell WILSON
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Patent number: 10561318Abstract: Methods, devices and systems for quantifying fluorescence and optical properties in a turbid medium such as tissue are disclosed. One of the methods comprises: providing fluorescence emission and reflectance wavelengths detected from a target surface where each of the detected wavelengths is associated with a respective known distance between a respective excitation source giving rise to the respective detected wavelength and a detector detecting the respective detected wavelength; and calculating the optical properties based on the detected wavelengths and the respective known distances. The known distances may be predetermined to enable calculation of a desired range of values for the optical properties. The calculation of the optical properties may be based on a model of light interaction with the turbid medium where the model limits a range of calculated values for the optical properties.Type: GrantFiled: January 25, 2011Date of Patent: February 18, 2020Assignee: University Health NetworkInventors: Anthony Taywon Kim, Brian Campbell Wilson
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Publication number: 20160278678Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared.Type: ApplicationFiled: February 15, 2016Publication date: September 29, 2016Inventors: Pablo Valdes, Frederic Leblone, Keith D. Paulsen, Brian Campbell Wilson, David W. Roberts, Michael Jermyn
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Patent number: 9134243Abstract: A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography.Type: GrantFiled: December 17, 2010Date of Patent: September 15, 2015Assignee: UNIVERSITY HEALTH NETWORKInventors: Brian Campbell Wilson, Anthony Taywon Kim
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Patent number: 8548562Abstract: An imaging and diagnostic system and method to differentiate between malignant and non-malignant tissue of a prostate and surrounding region. The system acquires imaging data from the prostate and surrounding proximal region, and processes the data to differentiate areas of tissue malignancy from non-malignant tissue. A sectioning device or ablative device is provided. The ablative device is operable by automation for receiving the imaging output coordinates and defining the trajectory and quantity of energy or power to be delivered into the malignant tissue. A control system determines calculated energy or power to be deposited into the malignant tissue during ablation, to minimize destruction of the non-malignant tissue within the prostate and surrounding tissue. The system operates on generated ablative device output data.Type: GrantFiled: March 16, 2007Date of Patent: October 1, 2013Inventors: John Trachtenberg, Masoom A. Haider, Brian Campbell Wilson
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Publication number: 20130006116Abstract: Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.Type: ApplicationFiled: January 25, 2011Publication date: January 3, 2013Applicant: UNIVERSITY HEALTH NETWORKInventors: Anthony Taywon Kim, Brian Campbell Wilson
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Publication number: 20120326055Abstract: A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography.Type: ApplicationFiled: December 17, 2010Publication date: December 27, 2012Applicant: UNIVERSITY HEALTH NETWORKInventors: Brian Campbell Wilson, Anthony Taywon Kim
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Publication number: 20100100084Abstract: The present invention relates to methods for laser surgery and growth factor stimulation for ultra-precision surgery with healing. The method is achieved by cutting biological tissue using an ultrafast laser, which produces laser pulses less than 10 picosecond in duration, to induce a cold ablation process in order to avoid the formation of carbonaceous or other materials that cannot be removed efficiently or completely from the wounded area through natural healing mechanisms. By use of femtosecond lasers, a negligible amount of debris is generated and an outer layer of intact but non viable cells are created principally through shock wave induce damage and ionizing radiation effects induced by multiphoton absorption of ultrashort laser pulses. The normal healing process is blocked by this outer layer of cells as all cell contacts are still intact. Therefore the healing process must be stimulated.Type: ApplicationFiled: August 3, 2006Publication date: April 22, 2010Inventors: Bruno Girard, Cameron Clokie, Brian Campbell Wilson, Robert John Dwayne Miller
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Publication number: 20070230757Abstract: An imaging and diagnostic system and method are used for differentiating between malignant and non-malignant tissue of a prostate and surrounding region. The imaging device of the system acquires imaging data from the prostate and surrounding proximal region, processes the data to differentiate areas of tissue malignancy from non-malignant tissue. A sectioning device or ablative device is provided. The ablative device is operable by automation for receiving the imaging output coordinates and defining the trajectory and quantity of energy or power to be delivered into the malignant tissue of the prostate region. A control system determines calculated energy or power to be deposited into the malignant tissue during ablation, to minimize destruction of the non-malignant tissue within the prostate and surrounding tissue. The system operates on generated ablative device output data.Type: ApplicationFiled: March 16, 2007Publication date: October 4, 2007Inventors: John Trachtenberg, Masoom A. Haider, Brian Campbell Wilson