Abstract: The present disclosure relates to a replication deficient oncolytic viral vector or replication capable group B oncolytic adenovirus selected from the group consisting of Ad11 and enadenotucirev, wherein the virus encodes an antibody or a binding fragment thereof for expression on the surface of a cancer cell, wherein said antibody or binding fragment is specific to a CD3 protein of a T-cell receptor complex (TCR), wherein the virus does not encode a B7 protein or an active fragment thereof, pharmaceutical compositions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.

Abstract: The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5?ITR-B1-BA-B2-BX-BB-BY-B3-3?ITR wherein: B1 is bond or comprises: E1A, E1B or E1A-E1B; BA comprises-E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; BB comprises L5; BY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B3 is a bond or comprises: E4; wherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses.

Abstract: The description relates to input devices that can be secured to and used to control various devices. One example input device can include a housing defining a top surface that includes controls. The housing can define a recess that includes generally opposing upper and lower surfaces that extends at least partially under and parallel to the top surface. A self-adjusting gripping mechanism can extend into the recess through the lower surface and can be biased toward the upper surface. The self-adjusting gripping mechanism can be configured to be contacted by devices having a range of thicknesses and configured to grip individual devices within the range of thicknesses between the self-adjusting gripping mechanism and the upper surface.

Abstract: The pressure regulator has a regulator body with a control chamber and outlet and inlet passageways opening thereto, a bonnet with a bonnet chamber and a diaphragm separating the chambers. A filter housing is mounted in the control chamber and mounts a filter and a valve seat that opens to the inlet passageway while spring urged mechanism moves the a valve stem to permit fluid flow through the valve seat and into the control chamber between the filter and diaphragm when the pressure therein falls below a preselected level, and then through the filter to the outlet passageway. When the pressure in the outlet passageway is at or above a preselected value, the pressure acts against a diaphragm whereby the piston retains the valve stem in a fluid flow blocking position.

Abstract: The pressure regulator has a regulator body with a control chamber and outlet and inlet passageways opening thereto, a bonnet with a bonnet chamber and a diaphragm separating the chambers. A filter housing is mounted in the control chamber and mounts a filter and a valve seat that opens to the inlet passageway while spring urged mechanism moves the a valve stem to permit fluid flow through the valve seat and into the control chamber between the filter and diaphragm when the pressure therein falls below a preselected level, and thence through the filter to the outlet passageway. When the pressure in the outlet passageway is at or above a preselected value, the pressure acts against a diaphragm whereby the piston retains the valve stem in a fluid flow blocking position.