Abstract: The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, or a tautomer thereof, or a hydrate thereof.

Abstract: A computer-implemented method for verifying identity of an asset can include transmitting, by a first asset, a challenge message at a challenge message transmit time. The challenge message can include a challenge response delay. The method can include receiving, by the first asset, a reply message at a reply message receive time. The reply message can be transmitted from a second asset that is in receipt of the challenge message. The method can include verifying, by the first asset, the second asset based on a comparison of the reply message receive time to a valid reply message receive time span that is based at least in part on the challenge message transmit time and the challenge response delay.

Abstract: A page or book for interacting with a non-human animal is provided. In various embodiments, a book is provided comprising a cover, a plurality of pages, at least one of the plurality of pages and/or cover having at least one element is provided that is attractive to the animal's sense of sight, smell, taste, touch, and/or sound, and optionally a spine for holding the cover and the plurality of pages. The book is designed so that the animal will sustain interest in the book and interact with the reader. In various embodiments, a page is provided, the page comprising at least one element that is attractive to the animal's sense of sight, smell, taste, touch, and/or sound.

Abstract: A page or book for interacting with a non-human animal is provided. In various embodiments, a book is provided comprising a cover, a plurality of pages, at least one of the plurality of pages and/or cover having at least one element is provided that is attractive to the animal's sense of sight, smell, taste, touch, and/or sound, and optionally a spine for holding the cover and the plurality of pages. The book is designed so that the animal will sustain interest in the book and interact with the reader. In various embodiments, a page is provided, the page comprising at least one element that is attractive to the animal's sense of sight, smell, taste, touch, and/or sound.

Abstract: A method of reducing package stress includes placing matched components of an op-amp substantially in a region of a die having the least stress gradients. The region is located in the center of the die. Further, the center is the common centroid of the die. The matched components are the current mirror input stages of the op-amp. In one embodiment, a semiconductor configuration includes a die having a region with the least stress gradients, and an op-amp containing matched components that are located substantially in the region.

Abstract: A computer system is disclosed that provides a presentation software application that is easily migrated across multiple computing platforms and operating systems. The software produces presentations that are scalable to conform to the user's display and are portable between computers independent of the computer's operating systems. Presentations may be made interactive by allowing a user to edit a presentation while that presentation is being presented by a second user.