Abstract: The present disclosure relates to a group B adenovirus comprising a sequence of formula (I): 5?ITR-B1-BA-B2-BX-BB-BY-B3-3?ITR wherein: B1 is bond or comprises: E1A, E1B or E1A-E1B; BA comprises-E2B-L1-L2-L3-E2A-L4; B2 is a bond or comprises: E3; BX is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; BB comprises L5; BY is a bond or a DNA sequence comprising: a restriction site, one or more transgenes or both; B3 is a bond or comprises: E4; wherein at least one of BX or BY is not a bond, pharmaceutical compositions comprising the same and use of the viruses and compositions in treatment, particularly in the treatment of cancer. The disclosure also extends to plasmids and processes employed to prepare the said viruses.

Abstract: Techniques for forking and merging of electronically presented content items, such as MMO and other video games, are described herein. In particular, a first content item session may be forked to generate a second (forked) content item session. The first and forked content item sessions may then continue to execute and evolve in separate directions from one another. In some examples, a user of the forked content item session may serve as an administrator of the forked content item session and may receive compensation in exchange for serving as an administrator. Additionally, one or more forked or other separate content item sessions may be merged together to form a merged content item session. In some examples, conflicts between merged content item sessions may be identified and resolved based, at least in part, on input from administrators.

Abstract: Techniques for implementation of an entity-component architecture with components having multiple configurations are described herein. In some examples, at least one component within an entity-component architecture of a video game may have multiple different configurations. Each of the multiple configurations may, for example, relate to a different respective deployment context in which the configuration will be deployed. For example, in some cases, the different configurations may be defined for different device types, such as client, server, and others. Additionally, in some cases, the different configurations may be defined for different types of game consoles, and other different software, hardware, and/or contextual attributes. Furthermore, in some cases, configurations may be defined for use during video game development, such as within an editing interface that is used for video game development.

Abstract: Techniques for virtual area generation and manipulation are described herein. The described techniques may be used, for example, for virtual areas in electronically presented content items, such as video games and other media items. In some examples, one or more interfaces may be provided that allow content developers to provide and specify a set of rules associated with the virtual area. The set of rules may include, for example, terrain rules, object rules, and other rules associated with other aspects of the virtual area. The terrain rules may include rules for generating, distributing, and/or manipulating different types of terrain, such as such as flat and/or buildable space, mountains, valleys, berms, rivers, lakes, oceans, deserts, forests, and many others. The object rules may include rules for generating, distributing, and/or manipulating different types of objects, such as trees, bushes, rocks, snow, grass, fish, birds, animals, people, vehicles, buildings, and others.

Abstract: Techniques for implementation of an entity-component architecture with components having multiple configurations are described herein. In some examples, at least one component within an entity-component architecture of a video game may have multiple different configurations. Each of the multiple configurations may, for example, relate to a different respective deployment context in which the configuration will be deployed. For example, in some cases, the different configurations may be defined for different device types, such as client, server, and others. Additionally, in some cases, the different configurations may be defined for different types of game consoles, and other different software, hardware, and/or contextual attributes. Furthermore, in some cases, configurations may be defined for use during video game development, such as within an editing interface that is used for video game development.

Abstract: Techniques for virtual area generation and manipulation are described herein. The described techniques may be used, for example, for virtual areas in electronically presented content items, such as video games and other media items. In some examples, one or more interfaces may be provided that allow content developers to provide and specify a set of rules associated with the virtual area. The set of rules may include, for example, terrain rules, object rules, and other rules associated with other aspects of the virtual area. The terrain rules may include rules for generating, distributing, and/or manipulating different types of terrain, such as such as flat and/or buildable space, mountains, valleys, berms, rivers, lakes, oceans, deserts, forests, and many others. The object rules may include rules for generating, distributing, and/or manipulating different types of objects, such as trees, bushes, rocks, snow, grass, fish, birds, animals, people, vehicles, buildings, and others.

Abstract: The disclosed techniques may employ components referred to herein as atoms for computing and maintaining of states. Unlike traditional actors, atoms may be capable of binding to other atoms to form a bound combination of atoms, referred to herein as a molecule. In some examples, while bound to other atoms, an atom may operate in a manner that is different from traditional actors. For example, in some cases, atoms that are bound to one another may be prohibited from concurrently performing different operations on their own separate states. Additionally, bound atoms may be operable to collectively (e.g., synchronously) perform shared operations on their associated states. Furthermore, a shared operation performed on the states of bound atoms may be performed atomically. Also, in some examples, bound atoms may be capable of communicating synchronously with one another and of synchronously accessing each other's states.

Abstract: Techniques for virtual area generation and manipulation are described herein. The described techniques may be used, for example, for virtual areas in electronically presented content items, such as video games and other media items. In some examples, one or more interfaces may be provided that allow content developers to provide and specify a set of rules associated with the virtual area. The set of rules may include, for example, terrain rules, object rules, and other rules associated with other aspects of the virtual area. The terrain rules may include rules for generating, distributing, and/or manipulating different types of terrain, such as such as flat and/or buildable space, mountains, valleys, berms, rivers, lakes, oceans, deserts, forests, and many others. The object rules may include rules for generating, distributing, and/or manipulating different types of objects, such as trees, bushes, rocks, snow, grass, fish, birds, animals, people, vehicles, buildings, and others.

Abstract: Techniques for forking and merging of electronically presented content items, such as MMO and other video games, are described herein. In particular, a first content item session may be forked to generate a second (forked) content item session. The first and forked content item sessions may then continue to execute and evolve in separate directions from one another. In some examples, a user of the forked content item session may serve as an administrator of the forked content item session and may receive compensation in exchange for serving as an administrator. Additionally, one or more forked or other separate content item sessions may be merged together to form a merged content item session. In some examples, conflicts between merged content item sessions may be identified and resolved based, at least in part, on input from administrators.

Abstract: Techniques for virtual area generation and manipulation are described herein. The described techniques may be used, for example, for virtual areas in electronically presented content items, such as video games and other media items. In some examples, one or more interfaces may be provided that allow content developers to provide and specify a set of rules associated with the virtual area. The set of rules may include, for example, terrain rules, object rules, and other rules associated with other aspects of the virtual area. The terrain rules may include rules for generating, distributing, and/or manipulating different types of terrain, such as such as flat and/or buildable space, mountains, valleys, berms, rivers, lakes, oceans, deserts, forests, and many others. The object rules may include rules for generating, distributing, and/or manipulating different types of objects, such as trees, bushes, rocks, snow, grass, fish, birds, animals, people, vehicles, buildings, and others.

Abstract: Various embodiments enable additional content or features to be displayed to a user in response to detecting one eye of the user being closed either as a wink or for a duration of time. In one example, the additional content is graphical overlay, such as a menu containing selectable graphical elements to perform functions related to an application, game, or content, of global navigational features of the computing device in general, or to alternate views, features, or supplemental content for an application or game currently being displayed on a computing device. In one example, the overlay may be displayed only as long as the user keeps one eye closed or, alternatively, the user could wink to display the overlay and provide some other input to remove the overlay.

Abstract: Approaches are described for generating an audio signal that mimics speech captured a computing device. An input audio signal (e.g., a speech signal) can be transformed from the time domain into another domain, to generate one or more audio signal segments, where each segment can correspond to a window of time. The device can then determine, for each audio signal segment, a feature characteristic of the audio signal, such as a phoneme. Each one of segments can be mapped, based at least in part on the respective feature characteristic, to a model audio signal. The device can then generate an output audio signal including each model audio signal as determined by the mapping, where the output audio signal is in a sequence associated with the input audio signal.

Abstract: Various embodiments enable additional content or features to be displayed to a user in response to detecting one eye of the user being closed either as a wink or for a duration of time. In one example, the additional content is graphical overlay, such as a menu containing selectable graphical elements to perform functions related to an application, game, or content, of global navigational features of the computing device in general, or to alternate views, features, or supplemental content for an application or game currently being displayed on a computing device. In one example, the overlay may be displayed only as long as the user keeps one eye closed or, alternatively, the user could wink to display the overlay and provide some other input to remove the overlay.