Abstract: The present disclosure relates to a combination of anti-human VEGFR-2 antibodies (Ramucirumab) and anti-human PD-L1 (durvalumab) antibodies for treating certain disorders, including advanced gastric or gastroesophageal junction adenocarcinomas, non-small cell lung cancer, and hepatocellular carcinomas. Sequences 3 & 4 represent Ramucirumab VL and VH; Sequences 7 & 8 those of Durvalumab.

Abstract: The present disclosure relates to a combination of ramucirumab and pembrolizumab and methods of using the combination to treat certain disorders, such as non-small cell lung cancer, urothelial cancer, biliary tract cancer, and advanced gastric or gastroesophageal junction adenocarcinoma.

Abstract: The present invention relates to a transformer assembly (1) and a process for manufacturing same. The transformer (1) comprises a primary winding (5) wound on a PCB (9) and a secondary winding (7) mounted adjacent to the primary winding. The primary winding comprises a spiral coil, for example of wire or insulated wire, wound on the PCB. Gate drive windings (31, 33) are incorporated in the PCB (9) and there is therefore very close coupling between the primary winding and the gate drive windings. Furthermore, the secondary winding (7) is a center-tapped secondary having two halves. A flux balance winding (13) is provided to connect the two halves of the center-tapped secondary winding (7) and minimize leakage inductance thereby reducing power loss and spiking effects and obviating the need for complex control arrangements.

Abstract: The present invention relates to a transformer assembly (1) and a process for manufacturing same. The transformer (1) comprises a primary winding (5) wound on a PCB (9) and a secondary winding (7) mounted adjacent to the primary winding. The primary winding comprises a spiral coil, for example of wire or insulated wire, wound on the PCB. Gate drive windings (31, 33) are incorporated in the PCB (9) and there is therefore very close coupling between the primary winding and the gate drive windings. Furthermore, the secondary winding (7) is a centre-tapped secondary having two halves. A flux balance winding (13) is provided to connect the two halves of the centre-tapped secondary winding (7) and minimise leakage inductance thereby reducing power loss and spiking effects and obviating the need for complex control arrangements.

Abstract: A transformer (1) for a printed circuit board (2) is provided with physically separate flat metal windings (6) which are chosen to take the highest or the two highest currents handled by the transformer (1). The lower currents which will often include the power input to the primary are printed on the surfaces (3,4) of the printed circuit board (2). The flat metal windings (5) may be pre-assembled with the core halves (6,7).