Patents by Inventor Brian Grot
Brian Grot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220267400Abstract: This disclosure relates to protease-cleavable IL-2 cytokine prodrugs. In some embodiments, the prodrugs comprise a pharmacokinetic modulator.Type: ApplicationFiled: July 24, 2020Publication date: August 25, 2022Inventors: Phillip S. KIM, Emma LANGLEY, Hsieng LU, Xinjun LIU, Tani Ann LEE, Brian GROT
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Patent number: 9250164Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: GrantFiled: February 5, 2014Date of Patent: February 2, 2016Assignee: Vertex Pharmaceuticals, IncorporatedInventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay Shivayogi Magavi
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Publication number: 20140154151Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: ApplicationFiled: February 5, 2014Publication date: June 5, 2014Applicant: Vertex Pharmaceuticals, IncorporatedInventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay Shivayogi Magavi
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Patent number: 8679406Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: GrantFiled: December 4, 2012Date of Patent: March 25, 2014Assignee: Vertex Pharmaceuticals, IncorporatedInventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay Shivayogi Magavi
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Patent number: 8398941Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: April 18, 2012Date of Patent: March 19, 2013Assignee: Vertex Pharmaceuticals Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 8337754Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: GrantFiled: December 22, 2009Date of Patent: December 25, 2012Assignee: Vertex Pharmaceuticals, IncorporatedInventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay S. Magavi
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Publication number: 20120201727Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: ApplicationFiled: April 18, 2012Publication date: August 9, 2012Applicant: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 8178055Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: May 29, 2009Date of Patent: May 15, 2012Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Publication number: 20110151482Abstract: Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.Type: ApplicationFiled: December 22, 2009Publication date: June 23, 2011Inventors: Michael P. Emery, Matthew C. Wallace, James E. Sinclair, Raymond J. Gonzales, Brian Grot, Sanjay S. Magavi
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Patent number: 7858044Abstract: A dual-use, high density plate for storage and assays includes a frame including a matrix of wells. The matrix includes preferably 3456 wells with top portions being arranged preferably approximately flush with a plane of the frame. A solvent-resistant material such as cyclo-olefin polymer forms at least the bottom portions of the wells, and preferably the same solvent resistant material forms the frame, although varying from the bottoms of the wells by being rendered opaque. Evaporation control wells are preferably included at the periphery of the matrix for reducing effects of evaporation on edge wells.Type: GrantFiled: April 30, 2004Date of Patent: December 28, 2010Assignee: Nexus Biosystems, Inc.Inventors: Peter J. Coassin, Todd Bennett, Brian Grot, David Nicol
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Publication number: 20090238727Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: ApplicationFiled: May 29, 2009Publication date: September 24, 2009Applicant: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 7553671Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: GrantFiled: May 25, 2004Date of Patent: June 30, 2009Assignee: Vertex Pharmaceuticals, Inc.Inventors: James E. Sinclair, Brian Grot
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Patent number: 7270784Abstract: The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling.Type: GrantFiled: April 30, 2004Date of Patent: September 18, 2007Assignee: Aurora Discovery, IncorporatedInventors: Minh Vuong, Todd Bennett, Javier Flores, Brian Grot, Daniel Hale, Huy Nguyen, Walter D. Niles, Tuong Phan, Steve Rodems, Jeff Stack, Peter J. Coassin
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Publication number: 20050265901Abstract: Disclosed herein is a modular test tube rack. The rack contains multiple sub-racks that can be coupled together to form the test tube rack. The sub-rack can be designed to fit into a variety of scientific instrumentation including a fixed rotor centrifuge. The assembled test tube rack can be of a format and size that allows use of standard array pipetters. Thus, a system is provided allowing use of standard array pipetters and high g centrifugation.Type: ApplicationFiled: May 25, 2004Publication date: December 1, 2005Inventors: James Sinclair, Brian Grot
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Publication number: 20050054083Abstract: The invention is an automated multiple-purpose, integrated laboratory system comprising interchangeable modular elements for the construction and measurement of biological assays. The functions of the modular elements may include multiwell platform handling, chemical reagent or cell management, volumetric transfer of liquids for assay construction or for recovery of reaction products for analysis, incubation under controlled environmental conditions, measurement of spectrometric signals originating from the assays, processing and analysis of the resulting spectrometric data, and other functions. The modular elements are arranged around a number of robotic elements that deliver plates to different modular elements, transfer plates to groups of modules served by a different robotic element, or other actions necessary in plate handling.Type: ApplicationFiled: April 30, 2004Publication date: March 10, 2005Inventors: Minh Vuong, Todd Bennett, Javier Flores, Brian Grot, Daniel Hale, Huy Nguyen, Walter Niles, Tuong Phan, Steve Rodems, Jeff Stack, Peter Coassin
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Publication number: 20050048575Abstract: A dual-use, high density plate for storage and assays includes a frame including a matrix of wells. The matrix includes preferably 3456 wells with top portions being arranged preferably approximately flush with a plane of the frame. A solvent-resistant material such as cyclo-olefin polymer forms at least the bottom portions of the wells, and preferably the same solvent resistant material forms the frame, although varying from the bottoms of the wells by being rendered opaque. Evaporation control wells are preferably included at the periphery of the matrix for reducing effects of evaporation on edge wells.Type: ApplicationFiled: April 30, 2004Publication date: March 3, 2005Inventors: Peter Coassin, Todd Bennett, Brian Grot, David Nicol