Patents by Inventor Brian H. Warrington

Brian H. Warrington has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzene compounds having two pyridazinone substituents
    Patent number: 4904664
    Abstract: The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): ##STR1## wherein: R.sup.1 is hydrogen or methyl;R.sup.2 is hydrogen or methyl; and represent double or single bonds; and the benzene ring is para- or meta-substituted; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 1, 1986
    Date of Patent: February 27, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Hunter D. Prain, Brian H. Warrington
  • Tricyclic pyridazinone compounds
    Patent number: 4755511
    Abstract: This invention relates to tricyclic pyridazinone compounds, pharmaceutical compositions containing the compounds, and a method of stimulating cardiac activity in a mammal by administering an effective amount of the compound. A compound of the invention is 7-carboxamido-4,4a-dihydro-4a-methyl-[5H]-indeno[1,2-c]-pyridazin-3[2H]-on e.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: July 5, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Brian H. Warrington
  • Heterocyclic compounds having inotropic activity
    Patent number: 4657906
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds has inotropic activity. One specific compound is 5-(4-acetamidophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: September 19, 1985
    Date of Patent: April 14, 1987
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: John C. Emmett, Robert A. Slater, Brian H. Warrington
  • 5-(4-Amino or acylaminophenyl)-2(1H)-pyrazinones having inotropic activity
    Patent number: 4556711
    Abstract: This invention relates to 5-(phenyl)-2(1H)-pyrazinones substituted in the 4-position of the phenyl ring by an amino or acylamino group. These compounds have inotropic activity. One specific compound is 5-(4-acetamidophenyl)-2(1H)-pyrazinone.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: December 3, 1985
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: John C. Emmett, Robert A. Slater, Brian H. Warrington
  • Process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone
    Patent number: 4528371
    Abstract: A process for preparing 6-(2-hydroxyphenyl)-3-pyridazinone which comprises reacting 2-hydroxyacetophenone with glyoxylic acid under alkaline conditions, adjusting the pH of the reaction mixture to give a mixture within a pH range of about pH 4.0-9.5 and which contains a weak base, and subsequently reacting with hydrazine.6-(2-Hydroxyphenyl)-3-pyridazinone is a useful intermediate in the preparation of anti-hypertensive agents.
    Type: Grant
    Filed: June 14, 1983
    Date of Patent: July 9, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, Brian H. Warrington