Abstract: An aiming device for a firearm comprising a housing and a near infrared illuminator. The near infrared illuminator is positioned in the housing and is configured to output near infrared light with adjustable beam divergence to provide a field of illumination that is adjustable. The near infrared illuminator includes a divergence adjustment input positioned on an upper side of the housing that is movable by a user to adjust the beam divergence.

Abstract: The present invention provides methods and compositions for reducing internalization and/or trafficking of tau in neuronal cells comprising contacting the cells with an effective amount of an LRP1 and/or SorLA antagonist. The invention further provides a method of treating or preventing Alzheimer's disease in a subject in need thereof, comprising administering to the subject an effective amount of an LRP1 and/or SorLA antagonist.

Abstract: A system including a chilled air generation system, a forced air convection system, one or more phase change material (PCM) modules, and a controller. The controller is configured to regulate the temperature of a facility by selectively utilizing the chilled air generation system and the forced air convection system based on multiple factors, which may include energy source type(s), relative costs of the energy from the source(s), availability of energy from the source(s), facility temperature, PCM module temperature, and/or temperature of goods stored within the facility, among other considerations. The controller may thus advantageously and cost-effectively control the periods of time during which the chilled air generation system is used and those during which the thermal energy stored in the PCM modules is used.

Abstract: Actuation apparatus for use with magnetically-triggered proximity switches are described herein. An example apparatus includes an actuator shaft having a first segment and a second segment, the first segment intersecting the second segment. The first segment defines a first end of the actuator shaft, and the second segment defines a second end of the actuator shaft opposite the first end. The second segment further defines a slot. The apparatus further includes a detector magnet assembly coupled to the first segment of the actuator shaft adjacent the first end. The apparatus further includes a switch arm coupled to the second segment of the actuator shaft. The switch arm includes a first end, a second end opposite the first end, and a portion located between the first and second ends of the switch arm. The portion of the switch arm is positioned in the slot of the actuator shaft.

Abstract: Actuation apparatus for use with magnetically-triggered proximity switches are described herein. An example apparatus includes an actuator shaft having a first segment and a second segment, the first segment intersecting the second segment. The first segment defines a first end of the actuator shaft, and the second segment defines a second end of the actuator shaft opposite the first end. The second segment further defines a slot. The apparatus further includes a detector magnet assembly coupled to the first segment of the actuator shaft adjacent the first end. The apparatus further includes a switch arm coupled to the second segment of the actuator shaft. The switch arm includes a first end, a second end opposite the first end, and a portion located between the first and second ends of the switch arm. The portion of the switch arm is positioned in the slot of the actuator shaft.

Abstract: A cooler includes a body. The cooler also includes a divider that divides an interior of the body into a first zone and a second zone. A first phase change material module is disposed in the first zone of the interior of the body and a second phase change material module is disposed in the second zone of the interior of the body.

Abstract: This invention relates to the regulation of FGF-1 export by cells. In addition, this invention provides methods of regulating the export of FGF-1 from the cell membrane, which methods include regulating the Syn-1 molecule to affect the formation of the FGF-Syn-1 complex, regulating the enzyme or protease which cleaves Syn-1 in the FGF-1 :Syn-1 complex to effect the release of FGF-1 from the cell membrane, or regulating the FGF-1:Syn-1 complex itself at or near the cell membrane. S100A13 is identified as an additional component of the FGF-1 export complex. Syn-1 truncation deletion mutants are also provided and functionally characterized. The invention also provides compositions related to the regulation of FGF-1 export.

Abstract: This invention relates to the regulation of FGF-1 export. In addition, this invention provides methods of regulating the export of FGF-1 from the cell membrane, which methods include regulating the Syn-1 molecule to affect the formation of the FGF-1:Syn-1 complex, regulating the enzyme or protease which cleaves Syn-1 in the FGF-1:Syn-1 complex to effect the release of FGF-1 from the cell membrane, or regulating the FGF-1:Syn-1 complex itself at or near the cell membrane. The invention also provides compositions related to the regulation of FGF-1 export.

Abstract: The invention relates to an air flow controllable register unit for controlling flow of air through the register from an air circulating system having a register air flow supply duct. The air flow is controlled in response to an externally provided control signal that commands the register flow control unit to provide differing air flow rates through the register. The register unit includes a register flow control apparatus which has a power generating device that includes a rotary mounted air turbine positioned within the register air flow supply duct. The air turbine is coupled to a generator to drive the same upon air flow against blades of the turbine. The air driven turbine initially restricts air flow of the register at system start-up.

Abstract: The invention is directed to a control system for an air delivery system having a supply duct through which air is delivered into at least one independently controlled zone or room through an air delivery register. The control system for one zone or room includes a wireless air flow control thermostat to transmit a wireless air flow control signal output to an electrically powered and electrically self sufficient register air flow control unit that controls the flow of the air through the register in response to receiving the wireless airflow control signal output. The electrically powered and electrically self sufficient register air flow control unit includes an electrical generator to provide power in response to flow of air through the register from the supply duct. The generated electric power is delivered to the register air flow control unit to thereby maintain the register flow control unit electrically self sufficient and free from the need of any outside electrical power source.