Abstract: MRI signals from two species such as fat and water are separated by repeatedly applying a steady state free precession (SSFP) sequence to an object with the phase of each RF excitation pulse in a sequence being increased by 2?n/N radians on each repetition, where acquisition number n ranges from 1 to N. Alternatively, center frequency for each scan is incremented compared with the first scan center frequency. Images are reconstructed from the acquired signals and summed. Slowing varying phase due to sources other than chemical shift can be removed. Species signals are separated based on phase (sign) of the summed image signals.

Abstract: MRI signals from two species such as fat and water are separated by repeatedly applying a steady state free precession (SSFP) sequence to an object with the phase of each RF excitation pulse in a sequence being increased by 2?n/N radians on each repetition, where acquisition number n ranges from 1 to N. Alternatively, center frequency for each scan is incremented compared with the first scan center frequency. Images are reconstructed from the acquired signals and summed. Slowing varying phase due to sources other than chemical shift can be removed. Species signals are separated based on phase (sign) of the summed image signals.

Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a disease or condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to methods for preparing compounds of Formula (I) and their use as medicaments in the treatment of diseases mediated by glucokinase.

Abstract: MRI signals from two species such as water and fat are separated by using two SSFP acquisitions (S1, S2) with the two species signals having two different phase differences (e.g., 180°, 90°) and binomial quadratic expansion in which the species are determined based on magnitude and sign of S1 and the magnitude of S2.

Abstract: Homodyne image reconstruction is combined with an iterative decomposition of water and fat from MR signals obtained from a partial k-space signal acquisition in order to maximize the resolution of calculated water and fat images. The method includes asymmetrical acquisition of under-sampled MRI data, obtaining low resolution images, and then estimating a magnetic field map and phase maps of water and fat image signals from the low resolution images. The acquired data is again filtered and Fourier transformed to obtain an estimate of combined fat and water signals using the estimated magnetic field map and phase maps. Water and fat images are then estimated from which phases of the water and fat images are determined. The real parts of the water and fat images are then used in calculating water and fat images using a homodyne process.

Abstract: A pulse sequence for use in steady state free precession (SSFP) imaging sequences includes a RF pulse and a time-varying gradient pulse based on a conventional design algorithm such as the Shinnar-LeRoux (SLR) pulse design algorithm and in which amplitude of the RF pulse and gradient pulse are increased while pulse time is decreased thereby reducing imaging time and improving slab profiles.

Abstract: A pulse sequence for use in steady state free precession (SSFP) imaging sequences includes a RF pulse and a time-varying gradient pulse based on a conventional design algorithm such as the Shinnar-LeRoux (SLR) pulse design algorithm and in which amplitude of the RF pulse and gradient pulse are increased while pulse time is decreased thereby reducing imaging time and improving slab profiles.

Abstract: Magnetic resonance imaging of a body uses steady state free precession with material separation for the selective imaging of two species, such as blood or fat. The refocusing property of SSFP is used with signal phase detection to suppress either water or lipid. Phase and/or frequency of the RF excitation pulse and repetition time are selected so that resonant frequencies of water, fw, and lipid, fl, are on opposite sides of the signal null frequency.

Abstract: Disclosed is a method of quantitatively separating tissue signals based on relaxation time differences. The method uses the transient signal decay in steady-state free precession (balanced SSFP) imaging to provide an alternative to standard CPMG methods of T2-relaxometry. The balanced SSFP technique allows 3-4 times the temporal resolution of CPMG, and also slows the short T2 decay so that it can be more accurately measured.

Abstract: A time-optimal MRI gradient design method utilizes constrained optimization to design minimum-time gradient waveforms that satisfy gradient amplitude and slew-rate limitations. Constraints are expressed as linear equations which are solved using linear programming, L1-norm formulation, or second-order cone programming (SOCP).

Abstract: Magnetic resonance imaging of a body uses steady state free precession with material separation for the selective imaging of two species, such as blood or fat. The refocusing property of SSFP is used with signal phase detection to suppress either water or lipid. Phase and/or frequency of the RF excitation pulse and repetition time are selected so that resonant frequencies of water, fw, and lipid, fl, are on opposite sides of the signal null frequency.

Abstract: The invention related to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, useful in the treatment of a 1

Abstract: The present invention relates to the use of certain benzoic acid derivatives of formula (I), as disclosed in the specification, which act as peroxisome proliferator activated receptor (PPAR) agonists, in particular states of insulin resistance including type 2 gamma receptors (PPAR), and so are useful therapeutically in the treatment of diabetes mellitus. Novel pharmaceutical compositions and novel compounds are also defined, together with methods of their production.

Abstract: A new technique for imaging a material with a high T2/T1 ratio such as articular cartilage uses driven equilibrium Fourier transform (DEFT), a method of enhancing signal strength without waiting for full T1 recovery. Compared to other methods, DEFT imaging provides a good combination of bright cartilage and high contrast between cartilage and surrounding tissue. Both theoretical predictions and images show that DEFT is a valuable method for imaging articular cartilage when compared to spoiled gradient recalled acquisition in the steady-state (SPGR) or fast spin echo (FSE). T2-decay, T1 recovery, echo time, magnetization density, proton density, and equilibrium density per proton are related by a derived equation.

Abstract: This invention concerns novel aminopyridinium compounds of the formula I wherein R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are selected from the following combinations: ##STR1## (a) one of R.sup.2 and R.sup.6 is a basic group selected from amino, alkylamino, dialkylamino of up to eight carbon atoms, pyrrolidino, piperidino and morpholino, or is alkyl, alkenyl, alkoxyalkyl, alkoxy, alkylthio, phenyl, phenylalkyl, cycloalkyl or cycloalkylalkyl; and the other of R.sup.2 and R.sup.6 is hydrogen, alkyl or one of the above defined basic groups;R.sup.1 is alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl, cycloalkylalkyl; and R.sup.3 and R.sup.5 are independently hydrogen, alkyl or alkenyl;(b) R.sup.2 is a basic group as defined above, R.sup.5 and R.sup.6 together form alkylene or, together with the appendant carbon atoms of the pyridine ring, complete a benzene ring; has any of the meanings defined in(a) above; and R.sup.3 is hydrogen, alkyl or alkenyl; and(c) R2 has any of the meanings defined above and R.sup.

Abstract: A current probe is provided which comprises a handle and a ring of magnetisable material for positioning around an electrical conductor, the ring being split into two portions one being fixed relative to the handle and the other being slidable therewithin between a position in which the ring is closed and a position in which the ring is open. The line of split of the ring is at an angle from the line of sliding movement of the linearly slidable portion. Damping is provided to prevent the slidable portion of the ring from too rapidly moving from a position in which the ring is open to a position in which the ring is closed.

Abstract: In a method of making asbestos-free friction facing material in the form of a water-laid sheet of cellulosic fibres, in which are distributed friction-imparting particles and particles of friction-modifier, the sheet containing a thermosetting phenolic resin which after curing binds the ingredients firmly together, the thermosetting phenolic resin is included in emulsified form in the aqueous suspension of ingredients from which the water-laid sheet is prepared.This leads to a product of more consistent friction performance than is obtained by post-sheeting impregnation with thermosetting phenolic resin.

Abstract: Non-asbestos flexible sheet material suitable for use in the manufacture of spiral wound gaskets is made by dewatering on a water-permeable conveyor a layer of aqueous slurry and compressing and drying the dewatered layer, the aqueous slurry employed being one that contains the following ingredients in the following proportions by dry weight:china clay 20-50%mica or chlorite 20-50%graphite 10-40%cellulose fibres 2-10%vitreous fibre in wool form 2-10%synthetic organic polymer binder 2-10%.

Abstract: Non-asbestos flexible sheet material suitable for use in gaskets for the exhaust manifold of an internal combustion engine is made by dewatering on a water-permeable conveyor a layer of aqueous slurry and compressing and drying the dewatered layer, the aqueous slurry employed being one that contains the following ingredients in the following proportions by dry weight:ball clay: 25-44%non-fibrous layer silicate: 25-40%graphite: 10-30%cellulose fibres: 3-15%synthetic rubber: 1-10%starch: 1-5%.

Abstract: Non-asbestos flexible sheet material suitable for use in gaskets for the cylinder head of an internal combustion engine is made by dewatering on a water-permeable conveyor a layer of aqueous slurry and compressing and drying the dewatered layer, the aqueous slurry employed being one that contains the following ingredients in the following proportions by dry weight:______________________________________ ball clay 25-44% calcium silicate of high specific 15-40% surface area cellulose fibres 3-15% organic polymer binder 5-15% fibrillated poly (aromatic amide) 1-15% fibres ______________________________________