Abstract: Breath sensor calibration methods and apparatus are described herein where a breath sensor device may generally comprise a sampling unit having a housing configured to receive a sample breath from a user and a sensor positioned within the housing. A processor in electrical communication with the sensor may be configured to determine a dissipation time when the sensor is exposed to a near-constant concentration level of CO detected from the breath sample down to an ambient level of CO detected. The processor may also be configured to calculate a time constant based on the dissipation time and a reduction from the near-constant concentration level to the ambient level. Furthermore, the processor may also be configured to apply the time constant to a transient response of the sensor to account for drift in calibrating the sensor.

Abstract: Breath sensor calibration methods and apparatus are described herein where a breath sensor device may generally comprise a sampling unit having a housing configured to receive a sample breath from a user and a sensor positioned within the housing. A processor in electrical communication with the sensor may be configured to determine a dissipation time when the sensor is exposed to a near-constant concentration level of CO detected from the breath sample down to an ambient level of CO detected. The processor may also be configured to calculate a time constant based on the dissipation time and a reduction from the near-constant concentration level to the ambient level. Furthermore, the processor may also be configured to apply the time constant to a transient response of the sensor to account for drift in calibrating the sensor.

Abstract: Breath sensor calibration methods and apparatus are described herein where a breath sensor device may generally comprise a sampling unit having a housing configured to receive a sample breath from a user and a sensor positioned within the housing. A processor in electrical communication with the sensor may be configured to determine a dissipation time when the sensor is exposed to a near-constant concentration level of CO detected from the breath sample down to an ambient level of CO detected. The processor may also be configured to calculate a time constant based on the dissipation time and a reduction from the near-constant concentration level to the ambient level. Furthermore, the processor may also be configured to apply the time constant to a transient response of the sensor to account for drift in calibrating the sensor.

Abstract: Breath sensor measurement methods and apparatus are described. One variation may generally comprise a sampling unit having a breath sampling port, at least one pressure sensor located within the sampling unit and in communication with the breath sampling port, and a processor in communication with the at least one pressure sensor. The processor may be configured to prompt a user with instructions to exhale a sample breath for a first predetermined period of time into the breath sampling port and to inhale for a second predetermined period of time through the breath sampling port. The processor may be configured to measure a pressure change via the pressure sensor over the first and second predetermined periods of time such that the processor determines a total volume of air corresponding to lung capacity of the user based on the pressure change over the first and second predetermined periods of time.

Abstract: This disclosure provides a single reactor that accommodates an affinity selector to separate analytes of interest, and an enzyme reactor that digest the analyte to suitable peptides for mass spectrometry. The single reactor formats described herein accommodate workflows wherein separation precedes digestion as well as workflows wherein digestion precedes separation selection.

Abstract: The disclosure provides an innovative immobilized enzyme reactor working system that includes improved reactor formats, heating element, optimum buffers, filtration apparatus and collection componentry for easy to use sample preparation. The system provides enhanced recovery, improved reproducibility and parallel processing capabilities capable of quantitatively processing hundreds of difficult to digest samples simultaneously in a shortened period of time.

Abstract: This disclosure provides a single reactor that accommodates an affinity selector to separate analytes of interest, and an enzyme reactor that digest the analyte to suitable peptides for mass spectrometry. The single reactor formats described herein accommodate workflows wherein separation precedes digestion as well as workflows wherein digestion precedes separation selection.

Abstract: The disclosure provides an innovative immobilized enzyme reactor working system that includes improved reactor formats, heating element, optimum buffers, filtration apparatus and collection componentry for easy to use sample preparation. The system provides enhanced recovery, improved reproducibility and parallel processing capabilities capable of quantitatively processing hundreds of difficult to digest samples simultaneously in a shortened period of time.