Abstract: The pharmacokinetic profile of the SGLT2 inhibitor bexagliflozin can be improved by formulating it as an extended release tablet. Compared with standard immediate-release dosage forms these tablets can permit a lower peak plasma concentration, Cmax, while maintaining plasma concentrations at therapeutic levels for a desired period. This can be used, for instance, to administer lower doses while still providing the same pharmacological effect.

Abstract: Methods, systems, and media for generating and evaluating street grids comprising: receiving street grid information corresponding to a plurality of locations, wherein the street grid information corresponding to a location is associated with vehicular traffic information; training a pedestrian comfort model using the street grid information and the vehicular traffic information, wherein an output of the pedestrian comfort model is a predicted pedestrian comfort score that is based on traffic congestion from the vehicular traffic information; receiving a plurality of potential street grids; evaluating each potential street grid in the plurality of potential street grids using the trained pedestrian comfort model, wherein the trained pedestrian comfort model generates predicted pedestrian comfort scores for portions of each potential street grid; and generating an augmented map of each potential street grid that presents the predicted pedestrian comfort scores for each portion of each potential street grid.

Abstract: A memory device comprising a programmable command-and-address (CA) interface and/or a programmable data interface is described. In an operational mode, two or more CA interfaces may be active. In another operational mode, at least one, but not all, CA interfaces may be active. In an operational mode, all of the data interfaces may be active. In another operational mode, at least one, but not all, data interfaces may be active. The memory device can include circuitry to select: an operational mode; a sub-mode within an operational mode; one or more CA interfaces as the active CA interface(s); a main CA interface from multiple active CA interfaces; and/or one or more data interfaces as the active data interfaces. The circuitry may perform these selection(s) based on one or more bits in one or more registers and/or one or more signals received on one or more pins.

Abstract: Methods and systems of exchanging data using payment cards with universal reference numbers are disclosed. A merchant computing system includes a merchant input/output assembly receiving a universal reference number from a customer at a point of sale. A merchant database retrievably stores a plurality of universal reference numbers and customer information associated with each of the plurality of universal reference numbers. A transaction circuit receives the universal reference number from the merchant input/output assembly, retrieves customer information associated with the universal reference number, and provides an output relating to a transaction based on the customer information.

Abstract: In accordance with an embodiment, described herein is a system and method for use of virtual reality and/or augmented reality with data center operations and cloud infrastructure services. The approach leverages virtual reality and/or augmented reality, and insights from various sources of data describing the operation of the data center, including data center analytics, for facilitating in-situ diagnostics, operations, monitoring, maintenance, repair, health prognostics, and remote collaboration, toward enhancing the efficiency of managing and running data centers.

Abstract: Methods, systems, and media for generating building layouts are provided.

Abstract: Methods, systems, and media for building configuration of one or more buildings are provided.

Abstract: Methods, systems, and media for generative urban design where maps are generated using fractals are provided. In some embodiments, the method comprises: identifying, using a hardware processor, area information for a particular geographic location; identifying, using the hardware processor, fractal generation parameters; generating, using the hardware processor, a fractal using the fractal generation parameters; generating, using the hardware processor, an array that represents the particular geographic location based on the fractal and the area information; and generating, using the hardware processor, one or more maps of the particular geographic location using the array.

Abstract: Methods, systems, and media for initiating and monitoring instances of workflows are provided.

Abstract: Methods, systems, and media for generating and evaluating street grids are provided.

Abstract: Methods, systems, and media for modifying open space access using generative design are provided.

Abstract: Methods, systems, and media for data visualization and navigation of multiple simulation results in urban design are provided.

Abstract: In accordance with an embodiment, described herein is a system and method for use of virtual reality and/or augmented reality with data center operations and cloud infrastructure services. The approach leverages virtual reality and/or augmented reality, and insights from various sources of data describing the operation of the data center, including data center analytics, for facilitating in-situ diagnostics, operations, monitoring, maintenance, repair, health prognostics, and remote collaboration, toward enhancing the efficiency of managing and running data centers.

Abstract: A stable aqueous composition comprising (a) about 10 to about 100 mg/ml of an anti-C5 antibody, (b) a surfactant, (c) a stabilizer, and (d) a buffer having a pH of about 5.0 to about 7.8, wherein the stabilizer is trehalose, sucrose, sorbitol, arginine, or a combination thereof is provided. In a particular embodiment, the stable aqueous composition consists essentially of (a) about 10 or about 50 mg/ml of an anti-C5 antibody, (b) about 0.01 to about 0.1% (w/v) of a surfactant, (c) about 1 to about 20 mM buffer having a pH of 5.5 to 7.5, and (d) a stabilizer selected from the group consisting of trehalose, sucrose, sorbitol, arginine, or a combination thereof. A method of treating a disorder in which C5 activity is detrimental in a subject comprising administering the stable aqueous composition to the subject also is provided.

Abstract: A systemic retaining tray for prepackaging faux eyelashes and a method of manufacturing the same is provided. Each retaining tray provides a plurality of spaced apart gutters formed into a tray substrate, each gutter provides a row of spaced apart communicating notches. First a double-sided adhesive tape substantially fills and adheres to the bottom of each notch but not the remaining portion of the gutter. Then a proximal end of a faux eyelash is attached to the portion of the double-sided adhesive tape filling each notch. Finally, a single-sided adhesive strip is lain over the row of notches sandwiching the proximal portions of each faux eyelash.

Abstract: A manufacturing method of a light bar includes providing a hard substrate; electrically connecting multiple optical source chips on the substrate, the multiple optical source chips being arranged along a length direction of the substrate in a predetermined spacing; and encapsulating the optical source chips and a top surface of the substrate with encapsulation polymer, thereby a topmost surface of the encapsulation polymer on the optical source chips and the substrate being located at the same level. The light bar obtained has efficient light coupling, simple and efficient manufacturing process, and meets requirements of compact and light product.

Abstract: An antibody specifically binding to angiopoietin-2, and antigen-binding fragments thereof, and a use thereof are disclosed.

Abstract: An antibody specifically binding to angiopoietin-2, and antigen-binding fragments thereof, and a use thereof are disclosed.