Patents by Inventor Brian J. Kirby
Brian J. Kirby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11352371Abstract: The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).Type: GrantFiled: August 6, 2020Date of Patent: June 7, 2022Assignee: Gilead Sciences, Inc.Inventors: Jamie G. Bates, Ana Z. Gonzalez Buenrostro, Hongyan Guo, Xiaochun Han, Brian J. Kirby, Yurong Lai, Michael L. Mitchell, Gregg M. Schwarzwalder, James G. Taylor, Ting Wang
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Publication number: 20210053990Abstract: The present disclosure relates generally to compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).Type: ApplicationFiled: August 6, 2020Publication date: February 25, 2021Inventors: Jamie G. Bates, Ana Z. Gonzalez Buenrostro, Hongyan Guo, Xiaochun Han, Brian J. Kirby, Yurong Lai, Michael L. Mitchell, Gregg M. Schwarzwalder, James G. Taylor, Ting Wang
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Patent number: 7754077Abstract: Laser-induced phase-separation polymerization of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to produce a porous polymer membrane with a thickness of about 15 ?m, which bonds to the glass microchannel and forms a semi-permeable membrane. Differential permeation through a membrane formed with pentaerythritol triacrylate was observed and quantified by comparing the response of the membrane to fluorescein and fluorescently tagging 200 nm latex microspheres. Differential permeation was observed and quantified by comparing the response to rhodamine 560 and lactalbumin protein in a membrane formed with SPE-methylene bisacrylamide. The porous membranes illustrate the capability for the present technique to integrate sample cleanup into chip-based analysis systems.Type: GrantFiled: July 5, 2007Date of Patent: July 13, 2010Assignee: Sandia CorporationInventors: Anup K. Singh, Brian J. Kirby, Timothy J. Shepodd
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Patent number: 7534315Abstract: Laser-induced phase-separation polymerization of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to produce a porous polymer membrane with a thickness of about 15 ?m, which bonds to the glass microchannel and forms a semi-permeable membrane. Differential permeation through a membrane formed with pentaerythritol triacrylate was observed and quantified by comparing the response of the membrane to fluorescein and fluorescently tagging 200 nm latex microspheres. Differential permeation was observed and quantified by comparing the response to rhodamine 560 and lactalbumin protein in a membrane formed with SPE-methylene bisacrylamide. The porous membranes illustrate the capability for the present technique to integrate sample cleanup into chip-based analysis systems.Type: GrantFiled: July 5, 2007Date of Patent: May 19, 2009Assignee: Sandia CorporationInventors: Anup K. Singh, Brian J. Kirby, Timothy J. Shepodd
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Patent number: 7264723Abstract: Laser-induced phase-separation polymerization of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to produce a porous polymer membrane with a thickness of about 15 ?m, which bonds to the glass microchannel and form a semi-permeable membrane. Differential permeation through a membrane formed with pentaerythritol triacrylate was observed and quantified by comparing the response of the membrane to fluorescein and fluorescently tagging 200 nm latex microspheres. Differential permeation was observed and quantified by comparing the response to rhodamine 560 and lactalbumin protein in a membrane formed with SPE-methylene bisacrylamide. The porous membranes illustrate the capability for the present technique to integrate sample cleanup into chip-based analysis systems.Type: GrantFiled: May 22, 2003Date of Patent: September 4, 2007Assignee: Sandia CorporationInventors: Anup K. Singh, Brian J. Kirby, Timothy J. Shepodd
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Patent number: 7022381Abstract: A microvalve having a cast-in-place and lithographically shaped mobile, polymer monolith for fluid flow control in microfluidic devices and method of manufacture. The microvalve contains a porous fluorinated polymer monolithic element whose pores are filled with an electrically insulating, high dielectric strength fluid, typically a perfluorinated liquid. This combination provides a microvalve that combines high dielectric strength with extremely low electrical conductivity. These microvalves have been shown to have resistivities of at least 100 G? and are compatible with solvents such as water at a pH between 2.7 and 9.0, 1-1 propanol, acetonitrile, and acetone.Type: GrantFiled: June 30, 2003Date of Patent: April 4, 2006Assignee: Sandia National LaboratoriesInventors: Brian J. Kirby, David S. Reichmuth, Timothy J. Shepodd
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Patent number: 6988402Abstract: A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by fluid pressure (either liquid or gas) against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine.Type: GrantFiled: September 4, 2003Date of Patent: January 24, 2006Assignee: Sandia National LaboratoriesInventors: Ernest F. Hasselbrink, Jr., Jason E. Rehm, Timothy J. Shepodd, Brian J. Kirby
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Patent number: 6952962Abstract: A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by fluid pressure (either liquid or gas) against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine.Type: GrantFiled: May 8, 2002Date of Patent: October 11, 2005Assignee: Sandia National LaboratoriesInventors: Ernest F. Hasselbrink, Jr., Jason E. Rehm, Timothy J. Shepodd, Brian J. Kirby
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Patent number: 6865939Abstract: A method for surface modification of microchannels and capillaries. The method produces a chemically inert surface having a lowered surface free energy and improved frictional properties by attaching a fluorinated alkane group to the surface. The coating is produced by hydrolysis of a silane agent that is functionalized with either alkoxy or chloro ligands and an uncharged C3-C10 fluorinated alkane chain. It has been found that the extent of surface coverage can be controlled by controlling the contact time from a minimum of about 2 minutes to a maximum of 120 minutes for complete surface coverage.Type: GrantFiled: September 16, 2002Date of Patent: March 15, 2005Assignee: Sandia Naitonal LaboratoriesInventors: Brian J. Kirby, Timothy Jon Shepodd
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Publication number: 20040173459Abstract: A method for improving the pumping performance of an electrokinetic pump. The addition of zwitterions to the pump fluid or electrolyte of an electrokinetic pump (EKP) has been found to improve the pumping performance by increasing the maximum pressure and flow rate generated and increasing the efficiency for a given applied voltage. Zwitterions comprise a class of molecules that contain separated positive and negative charge centers within the molecule, are substantially electrically neutral, and generally exhibit a large inherent dipole moment (≈20−25 D) as a consequence of charge separation within the structure of the molecule. The addition of the zwitterion trimethyl ammonium propane sulfonate to an EKP electrolyte has resulted in a 3-fold increase in pump efficiency and a 2.5-fold increase in generated pressure for a given applied voltage.Type: ApplicationFiled: March 12, 2004Publication date: September 9, 2004Inventor: Brian J. Kirby
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Publication number: 20040123658Abstract: A microvalve having a cast-in-place and lithographically shaped mobile, polymer monolith for fluid flow control in microfluidic devices and method of manufacture. The microvalve contains a porous fluorinated polymer monolithic element whose pores are filled with an electrically insulating, high dielectric strength fluid, typically a perfluorinated liquid. This combination provides a microvalve that combines high dielectric strength with extremely low electrical conductivity. These microvalves have been shown to have resistivities of at least 100 G&OHgr; and are compatible with solvents such as water at a pH between 2.7 and 9.0, 1-1 propanol, acetonitrile, and acetone.Type: ApplicationFiled: June 30, 2003Publication date: July 1, 2004Inventors: Brian J. Kirby, David S. Reichmuth, Timothy J. Shepodd
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Publication number: 20040084370Abstract: Laser-induced phase-separation polymerization of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to produce a porous polymer membrane with a thickness of about 15 &mgr;m, which bonds to the glass microchannel and form a semi-permeable membrane. Differential permeation through a membrane formed with pentaerythritol triacrylate was observed and quantified by comparing the response of the membrane to fluorescein and fluorescently tagging 200 nm latex microspheres. Differential permeation was observed and quantified by comparing the response to rhodamine 560 and lactalbumin protein in a membrane formed with SPE-methylene bisacrylamide. The porous membranes illustrate the capability for the present technique to integrate sample cleanup into chip-based analysis systems.Type: ApplicationFiled: May 22, 2003Publication date: May 6, 2004Inventors: Anup K. Singh, Brian J. Kirby, Timothy J. Shepodd
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Publication number: 20040057835Abstract: A method for improving the pumping performance of an electrokinetic pump. The addition of zwitterions to the pump fluid or electrolyte of an electrokinetic pump (EKP) has been found to improve the pumping performance by increasing the maximum pressure and flow rate generated and increasing the efficiency for a given applied voltage. Zwitterions comprise a class of molecules that contain separated positive and negative charge centers within the molecule, are substantially electrically neutral, and generally exhibit a large inherent dipole moment (≈20-25 D) as a consequence of charge separation within the structure of the molecule. The addition of the zwitterion trimethyl ammonium propane sulfonate to an EKP electrolyte has resulted in a 3-fold increase in pump efficiency and a 2.5-fold increase in generated pressure for a given applied voltage.Type: ApplicationFiled: September 24, 2002Publication date: March 25, 2004Inventor: Brian J. Kirby
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Publication number: 20040052929Abstract: A method for surface modification of microchannels and capillaries. The method produces a chemically inert surface having a lowered surface free energy and improved frictional properties by attaching a fluorinated alkane group to the surface. The coating is produced by hydrolysis of a silane agent that is functionalized with either alkoxy or chloro ligands and an uncharged C3-C10 fluorinated alkane chain. It has been found that the extent of surface coverage can be controlled by controlling the contact time from a minimum of about 2 minutes to a maximum of 120 minutes for complete surface coverage.Type: ApplicationFiled: September 16, 2002Publication date: March 18, 2004Inventors: Brian J. Kirby, Timothy Jon Shepodd
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Publication number: 20020194909Abstract: A cast-in-place and lithographically shaped mobile, monolithic polymer element for fluid flow control in microfluidic devices and method of manufacture. Microfluid flow control devices, or microvalves that provide for control of fluid or ionic current flow can be made incorporating a cast-in-place, mobile monolithic polymer element, disposed within a microchannel, and driven by fluid pressure (either liquid or gas) against a retaining or sealing surface. The polymer elements are made by the application of lithographic methods to monomer mixtures formulated in such a way that the polymer will not bond to microchannel walls. The polymer elements can seal against pressures greater than 5000 psi, and have a response time on the order of milliseconds. By the use of energetic radiation it is possible to depolymerize selected regions of the polymer element to form shapes that cannot be produced by conventional lithographic patterning and would be impossible to machine.Type: ApplicationFiled: May 8, 2002Publication date: December 26, 2002Inventors: Ernest F. Hasselbrink, Jason E. Rehm, Timothy J. Shepodd, Brian J. Kirby