Abstract: An inflatable balloon is disposed into a body cavity and inflated to expand into the body cavity. A subcutaneously implanted, resealable catheter is coupled to the inflatable balloon. The resealable catheter provides repetitive access for an optical fiber disposed through a first lumen to illuminate the inner surface and for a radiation source disposed on the distal tip of a wire to provide repetitive long term, fractionated photodynamic and radiation therapy to tissues adjacent to the inner surface. A light diffusing fluid is disposed in the inflatable balloon. The catheter has a self-healing membrane coupled to and closing its proximal end. An insert is coupled to the proximal end and to the first lumen in the subcutaneous, resealable catheter.