Abstract: A fluid displacement and pressurization device which provides both a substantial amount of thread engagement as well as provides for single hand control for all operational manipulations including maintaining a set fill volume, rapid filling and displacement, and pressurization and retention of evacuation positioning during balloon depressurization. The device allows for the use of one hand to not only transition the device from micro-movement control to macro-movement control, but also regarding rotating, pushing or pulling the handle of the plunger.

Abstract: A touch free, spice dispenser is provided including a container for holding spices, a holder for supporting the container on an external support, a grinding mechanism and a sensor for activating the grinding mechanism in response to the presence of an object. The container has an open end and a closed end. The holder includes an end cap for support of the container, a hook for engagement with a support member and a strap extending between the hook and the end cap. The grinding mechanism is positioned in the end cap of the holder and is in electrical communication with a contact pad located on the hook. The grinding mechanism includes a grinder plate and a motor to rotate the grinder plate in response to a signal received from the sensor. Holes in the grinder plate and apertures in the end cap allow for passage of the spices out of the dispenser. A support assembly is also provided for supporting the dispenser above a food item.

Abstract: A touch free, spice dispenser is provided including a container for holding spices, a holder for supporting the container on an external support, a grinding mechanism and a sensor for activating the grinding mechanism in response to the presence of an object. The container has an open end and a closed end. The holder includes an end cap for support of the container, a hook for engagement with a support member and a strap extending between the hook and the end cap. The grinding mechanism is positioned in the end cap of the holder and is in electrical communication with a contact pad located on the hook. The grinding mechanism includes a grinder plate and a motor to rotate the grinder plate in response to a signal received from the sensor. Holes in the grinder plate and apertures in the end cap allow for passage of the spices out of the dispenser. A support assembly is also provided for supporting the dispenser above a food item.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: A touch free, spice dispenser is provided including a container for holding spices, a holder for supporting the container on an external support, a grinding mechanism and a sensor for activating the grinding mechanism in response to the presence of an object. The container has an open end and a closed end. The holder includes an end cap for support of the container, a hook for engagement with a support member and a strap extending between the hook and the end cap. The grinding mechanism is positioned in the end cap of the holder and is in electrical communication with a contact pad located on the hook. The grinding mechanism includes a grinder plate and a motor to rotate the grinder plate in response to a signal received from the sensor. Holes in the grinder plate and apertures in the end cap allow for passage of the spices out of the dispenser. A support assembly is also provided for supporting the dispenser above a food item.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.