Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (TLD), or chronic kidney disease (CKD).

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).

Abstract: A computer system, computer readable medium and computer-implemented method includes connecting to a database on a server that maintains schedule data of third parties; monitoring desired appointments of at least one subscriber account against the availability profiles of the at least one third party entry of the schedule data in the database; receiving a cancellation of an appointment; updating the availability profile of the third party entry in the database that corresponds to the canceled appointment; creating a cancellation notification based on existing desired appointments for the third party entry; sending a cancellation notification to at least one of the at least one subscriber; accepting input related to the cancellation notification from subscribers to whom a cancellation notification was sent; updating the database to add the canceled appointment and associated subscriber information from a subscriber based on the input from the subscribers; and notifying about the updated canceled appointment.

Abstract: A container for housing an injectable fluid vial. The container includes a calculation aid formed specific to the injectable fluid vial. The container is formed from a bottom, a top, and an inset side wall therebetween with a resealable lid. The top includes an opening constructed and arranged to receive the fluid vial housing. Alternatively, the container is formed from two half sections that are hinged together for holding the fluid vial housing therebetween. An inner label is permanently attached to the sidewall having at least one row of dosing indicia coordinated with a base line indicia selected from the group of weight, age, fluid volume or area. An outer label is rotatably secured over said inner label with at least one transparent window allowing selective viewing of the dosing and base line indicia and predetermined dosing rate.

Abstract: The present invention is directed toward a method of administering an oral solution containing one or more active ingredients, preferably formulations for non-prescription medicines, vital fluids, and/or nutritional supplements, optimally dosed based upon a patient's weight. The method includes providing an oral solution having an effective amount of one or more active ingredients; determining the weight of the individual, preferably to an individual less than 12 years old; and administrating an appropriate amount of the oral solution in a single dose dispensing unit in accordance with the weight determination of the individual, whereby the total amount of active ingredient administered corresponds to an effective amount of the active ingredient based on the individual's weight.

Abstract: A container for housing an injectable fluid vial. The container includes a calculation aid formed specific to the injectable fluid vial. The container is formed from a bottom, a top, and an inset side wall therebetween with a resealable lid. The top includes an opening constructed and arranged to receive the fluid vial housing. Alternatively, the container is formed from two half sections that are hinged together for holding the fluid vial housing therebetween. An inner label is permanently attached to the sidewall having at least one row of dosing indicia coordinated with a base line indicia selected from the group of weight, age, fluid volume or area. An outer label is rotatably secured over said inner label with at least one transparent window allowing selective viewing of the dosing and base line indicia and predetermined dosing rate.

Abstract: The present invention is directed toward a method of administering an oral solution containing one or more active ingredients, preferably formulations for non-prescription medicines, vital fluids, and/or nutritional supplements, optimally dosed based upon a patient's weight. The method includes providing an oral solution having an effective amount of one or more active ingredients; determining the weight of the individual, preferably to an individual less than 12 years old; and administrating an appropriate amount of the oral solution in a single dose dispensing unit in accordance with the weight determination of the individual, whereby the total amount of active ingredient administered corresponds to an effective amount of the active ingredient based on the individual's weight.

Abstract: A calculation aid is disclosed forming an integral part of a medication bottle. The calculation aid provides a reference chart for pediatric elixirs to assist in the accurate calculation of the weight-specific dosage for a child. The bottle includes parallel columns of patient's weights and rows of calculated quantity of elixir corresponding to the calculated dose. A movable indicator with an aperture allows selected viewing of the indicia.

Abstract: A calculation aid is disclosed forming an integral part of a medication bottle. The calculation aid provides a reference chart for pediatric elixirs to assist in the accurate calculation of the weight-specific dosage for a child. The bottle includes parallel columns of patient's weights and rows of calculated quantity of elixir corresponding to the calculated dose. A movable indicator with an aperture allows selected viewing of the indicia.

Abstract: A calculation aid is disclosed forming an integral part of a medication bottle or closure cap. The calculation aid, in essence, is a detailed weight-dose conversion chart, promoting the accurate dispensing of the weight-specific dosage of a given elixir to a child. The closure cap or bottle includes a parallel rows of indicia for the weight a child, calculated doses appropriate for the specific weight, and calculated quantity of elixir corresponding to the calculated dose. An aperture sleeve allows selected viewing of the indicia.