Patents by Inventor Brian Kelsall

Brian Kelsall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
    Publication number: 20060228360
    Abstract: The present invention provides a method for enhancing oral tolerance to an antigen associated with an autoimmune disease in a subject having the autoimmune disease comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to enhance oral tolerance. Also provided in the present invention is a method for treating or preventing an autoimmune disease in a subject comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to treat or prevent the autoimmune disease, thereby treating or preventing the autoimmune disease.
    Type: Application
    Filed: June 9, 2006
    Publication date: October 12, 2006
    Inventors: Warren Strober, Brian Kelsall, Thomas Marth
  • Mucosal cytotoxic T lymphocyte responses
    Publication number: 20050232897
    Abstract: The invention provides methods for induction of an antigen-specific, mucosal cytotoxic T lymphocyte response useful in preventing and treating infections with pathogens that gain entry via a mucosal surface.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 20, 2005
    Applicant: Health and Human Services, The Government of the United States of America, as Represented by
    Inventors: Jay Berzofsky, Igor Belyakov, Michael Derby, Brian Kelsall, Warren Strober
  • Methods of using CR3 and CR4 ligands for inhibiting interleukin-12 to treat autoimmune disease
    Publication number: 20040136994
    Abstract: The present invention provides a method of downregulating interleukin-12 production in a subject, comprising administering to the subject an interleukin-12 downregulating amount of a ligand of complement receptor 3 and/or complement receptor 4 effective in downregulating interleukin-12 production. Also provided is a method of reducing an interleukin-12-induced inflammatory response in a subject, comprising administering to the subject an amount of a ligand of complement receptor 3 and/or complement receptor 4 effective in reducing the interleukin-12-induced inflammatory response. In addition, the present invention provides a method of reducing the symptoms characteristic of an autoimmune disease by downregulating interleukin-12 production, comprising administering to the subject an amount of a ligand of complement receptor 3 or complement receptor 4 effective in downregulating interleukin-12 production, thereby reducing the symptoms characteristic of an autoimmune disease.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Inventors: Brian Kelsall, Warren Strober, Ivan Fuss, Thomas Marth
  • Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
    Publication number: 20030228311
    Abstract: The present invention provides a method for enhancing oral tolerance to an antigen associated with an autoimmune disease in a subject having the autoimmune disease comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to enhance oral tolerance. Also provided in the present invention is a method for treating or preventing an autoimmune disease in a subject comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to treat or prevent the auto immune disease, thereby treating or preventing the autoimmune disease.
    Type: Application
    Filed: April 21, 2003
    Publication date: December 11, 2003
    Inventors: Warren Strober, Brian Kelsall, Thomas Marth
  • Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
    Publication number: 20010051159
    Abstract: The present invention provides a method for enhancing oral tolerance to an antigen associated with an autoimmune disease in a subject having the autoimmune disease comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to enhance oral tolerance. Also provided in the present invention is a method for treating or preventing an autoimmune disease in a subject comprising orally administering to the subject an antigen associated with the autoimmune disease and administering an inhibitor of interleukin-12 in amounts sufficient to treat or prevent the autoimmune disease, thereby treating or preventing the autoimmune disease.
    Type: Application
    Filed: December 7, 2000
    Publication date: December 13, 2001
    Applicant: Government of the United States of America, Department of Health and Human Services
    Inventors: Warren Strober, Brian Kelsall, Thomas Marth