Patents by Inventor Brian Ledford

Brian Ledford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaminotriazoles useful as inhibitors of protein kinases
    Publication number: 20040214817
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: November 17, 2003
    Publication date: October 28, 2004
    Inventors: Albert C. Pierce, Michael Amost, Robert J. Davies, Cornelia J. Forster, Vincent Galullo, Ronald Grey, Mark Ledeboer, Shi-Kai Tian, Jinwang Xu, Hayley Binch, Brian Ledford, David Messersmith, Suganthi Nanthakumar, Andrew Jayaraj, Greg Henkel, Francesco G. Salituro, Jian Wang
  • Compositions useful as inhibitors of JAK and other protein kinases
    Publication number: 20040147507
    Abstract: The present invention provides a compound of formula I: 1
    Type: Application
    Filed: November 3, 2003
    Publication date: July 29, 2004
    Inventors: Mark Ledeboer, Brian Ledford
  • Isoxazoles and uses thereof
    Publication number: 20040132755
    Abstract: The present invention provides a compound of formula I: 1
    Type: Application
    Filed: September 8, 2003
    Publication date: July 8, 2004
    Inventors: Mark Ledeboer, Brian Ledford, Francesco G. Salituro
  • N-heterocyclic derivatives
    Patent number: 6747042
    Abstract: The present invention relates N-heterocyclic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: June 8, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Protein kinase inhibitors and uses thereof
    Publication number: 20040106615
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formulae I and V: 1
    Type: Application
    Filed: August 12, 2003
    Publication date: June 3, 2004
    Inventors: John Cochran, Jeremy Green, Michael R. Hale, Brian Ledford, Francois Maltais, Suganthini Nanthakumar
  • N-substituted glycine derivatives
    Publication number: 20040072821
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 15, 2004
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • N-substituted glycine derivatives
    Patent number: 6677359
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: January 13, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Cyclized amino acid derivatives
    Publication number: 20030186960
    Abstract: The present invention relates to cyclized amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: October 2, 2003
    Inventors: David Lauffer, Brian Ledford
  • Cyclized amide derivatives
    Publication number: 20030130256
    Abstract: The present invention relates to cyclized amide derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: February 5, 2003
    Publication date: July 10, 2003
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • CAK inhibitors and uses thereof
    Publication number: 20030119793
    Abstract: The present invention relates to compounds useful as inhibitors of CAK, compositions thereof. The present invention also relates to methods using the compositions for treating CAK-mediated diseases, such as fungal infections.
    Type: Application
    Filed: June 6, 2002
    Publication date: June 26, 2003
    Inventors: Brian Ledford, Cameron Stuver Moody, Michael Mullican, Mark Namchuk
  • Cyclized amide derivatives
    Patent number: 6552041
    Abstract: The present invention relates to cyclized amide derivatives of formula (I) These cyclized amide derivatives are useful for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 22, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • Cyclized amide derivatives
    Publication number: 20020107239
    Abstract: The present invention relates to cyclized amide derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 8, 2002
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • N-substituted glycine derivatives
    Publication number: 20020107240
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 8, 2002
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • N-heterocyclic derivatives
    Publication number: 20020107241
    Abstract: The present invention relates N-heterocyclic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Application
    Filed: January 3, 2002
    Publication date: August 8, 2002
    Inventors: David Lauffer, Brian Ledford, Michael Mullican