Patents by Inventor Brian M. Holmes
Brian M. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180304001Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.Type: ApplicationFiled: April 20, 2018Publication date: October 25, 2018Applicant: Terumo BCT, Inc.Inventors: Thomas J. FELT, Dennis J. HLAVINKA, Brian M. HOLMES
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Publication number: 20180304003Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.Type: ApplicationFiled: April 20, 2018Publication date: October 25, 2018Applicant: Terumo BCT, Inc.Inventors: Taylor POLODNA, Brian M. HOLMES
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Publication number: 20180304004Abstract: Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.Type: ApplicationFiled: April 20, 2018Publication date: October 25, 2018Applicant: Terumo BCT, Inc.Inventors: Brian M. Holmes, Thomas J. Felt, Peter O'Brien
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Patent number: 9737898Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: GrantFiled: September 10, 2015Date of Patent: August 22, 2017Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, James R. Ladtkow
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Patent number: 9435736Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: GrantFiled: August 29, 2013Date of Patent: September 6, 2016Assignee: Terumo BCT, Inc.Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
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Publication number: 20150375238Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: ApplicationFiled: September 10, 2015Publication date: December 31, 2015Applicant: TERUMO BCT, INC.Inventors: Brian M. HOLMES, James R. LADTKOW
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Patent number: 9156039Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: GrantFiled: June 12, 2012Date of Patent: October 13, 2015Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, James R. Ladtkow
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Patent number: 8992402Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.Type: GrantFiled: May 23, 2012Date of Patent: March 31, 2015Assignee: Terumo BCT, Inc.Inventor: Brian M. Holmes
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Patent number: 8900112Abstract: A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.Type: GrantFiled: July 5, 2011Date of Patent: December 2, 2014Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, Briden Ray Stanton, Geert Van Waeg, Mary Langley
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Publication number: 20140322550Abstract: Presently described are curable compositions comprising a mixture of at least one (e.g. free-radically) polymerizable ionic liquid and at least one other ethylenically unsaturated monomer, oligomer, or polymer. The polymerizable ionic liquid is characterized as having an air to nitrogen curing exotherm ratio of at least 0.70. Also described are articles and methods of making articles from such curable compositions. A monofunctional polymerizable ionic liquid is also described comprising a non-polymerizable substituted imidazolium cationic group and a polymerizable sulfonate anion.Type: ApplicationFiled: July 15, 2014Publication date: October 30, 2014Inventors: YIZHONG WANG, JOEL D. OXMAN, LARRY R. KREPSKI, PEIWANG ZHU, KEVIN M. LEWANDOWSKI, BRIAN M. HOLMES, RICHARD L. SEVERANCE, JOSEPH D. RULE, THOMAS P. KLUN
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Publication number: 20140005023Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: ApplicationFiled: August 29, 2013Publication date: January 2, 2014Applicant: Terumo BCT, Inc.Inventors: Jeremy P. KOLENBRANDER, Brian M. HOLMES, Thomas J. FELT, James R. LADTKOW
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Patent number: 8535210Abstract: A centrifugal blood separation system comprising a rotor, a light source, an optical sensor, a control system, a separation vessel, and an optical cell on the separation vessel. The optical cell has a first extraction port extending radially outwardly into the optical cell, a red blood cell extraction port downstream from the first extraction port and extending into the optical cell beyond the first extraction port; and a dam between said first extraction port and said red blood cell extraction port, having an upper edge and a lower edge, wherein the first extraction port and the red cell extraction port are radially between the upper edge and the lower edge of the dam. Also, a first extraction port having a bore having a first diameter, a lumen having a second diameter smaller than the first diameter, and a frustro-conical passageway coupling the bore to the lumen.Type: GrantFiled: December 3, 2010Date of Patent: September 17, 2013Assignee: Terumo BCT, Inc.Inventors: Jeremy P. Kolenbrander, Brian M. Holmes, Thomas J. Felt, James R. Ladtkow
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Publication number: 20120316049Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.Type: ApplicationFiled: June 12, 2012Publication date: December 13, 2012Applicant: TERUMO BCT, INC.Inventors: Brian M. HOLMES, James R. LADTKOW
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Publication number: 20120316051Abstract: A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.Type: ApplicationFiled: May 23, 2012Publication date: December 13, 2012Applicant: TERUMO BCT, INC.Inventor: Brian M. HOLMES
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Patent number: 8287742Abstract: Method for separating a volume of whole blood into at least a plasma component and a red blood cell component comprising centrifuging a separation bag containing a volume of whole blood so as to separate therein at least a first component comprising plasma and a second component comprising red blood cells; transferring the first component into a plasma component bag during centrifugation of the separation bag; transferring into the separation bag a volume of wash solution from a wash solution bag during centrifugation of the separation bag; mixing the volume of wash solution with the second component; centrifuging the separation bag so as to separate therein a washed red blood cell component and a supernatant component; and transferring the supernatant component into a waste bag during centrifugation of the separation bag.Type: GrantFiled: December 5, 2007Date of Patent: October 16, 2012Assignee: Terumo BCT, Inc.Inventor: Brian M. Holmes
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Patent number: 8277406Abstract: A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.Type: GrantFiled: December 8, 2009Date of Patent: October 2, 2012Assignee: Terumo BCT, Inc.Inventors: Thomas Felt, Brian M. Holmes, Bruce Gibbs
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Patent number: 8236184Abstract: A method related to using a squeezing or transfer fluid to transfer fluid or components between bags in a centrifuge wherein the squeezing fluid can be reversed to reduce squeezing and such fluid an also be used to build up a over-pressure for rapid movement.Type: GrantFiled: October 31, 2007Date of Patent: August 7, 2012Assignee: Terumo BCT, Inc.Inventors: Brian M. Holmes, Peter Pihlstedt
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Patent number: 8173027Abstract: Method for separating a volume of composite liquid into at least a first component and a second component including centrifuging a separation bag containing a volume of composite liquid and a volume of gas so as to sediment at least a first component and a second component separation bag; displacing a volume of hydraulic fluid against the separation bag to cause a transfer of at least one fraction of the content of the separation bag into at least one component bag connected to the separation bag; determining the volume of hydraulic fluid displaced and determining the volume of the composite liquid or the transferred components from the determined volume of displaced hydraulic fluid.Type: GrantFiled: August 28, 2007Date of Patent: May 8, 2012Assignee: Terumo BCT, Inc.Inventors: Niclas Högberg, Brian M. Holmes, Briden Ray Stanton, Lars Persson, Lars Strandberg, Peter Pihlstedt
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Publication number: 20120015794Abstract: A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.Type: ApplicationFiled: July 5, 2011Publication date: January 19, 2012Applicant: CARIDIANBCT, INC.Inventors: Brian M. HOLMES, Briden Ray STANTON, Geert VAN WAEG, Robert Langley, Mary Langley
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Patent number: 8057377Abstract: A bag loader for loading and unloading at least one satellite bag into and from the central compartment of a rotor of an apparatus for separating a composite liquid into at least two components comprises an upper part for removably securing an upper portion of at least one satellite bag; a lower part comprising a receptacle; and an intermediate part connecting the upper part to the lower part and exposing an intermediate portion of a satellite bag.Type: GrantFiled: August 14, 2006Date of Patent: November 15, 2011Assignee: CaridianBCT, IncInventors: Brian M. Holmes, Johan-Petter Hagström, Charles L. Hake