Patents by Inventor Brian McDonnell
Brian McDonnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11674117Abstract: The present invention relates to a starter culture comprising at least two Streptococcus thermophilus strains, wherein a first and a second Streptococcus thermophilus strain are chosen from RGP group 1, RGP group 2, RGP group 3 and RGP group 4, with the proviso that the first and second Streptococcus thermophilus strains do not belong to the same RGP group.Type: GrantFiled: December 14, 2017Date of Patent: June 13, 2023Assignee: DSM IP ASSETS B.V.Inventors: Roelof Hendrik Matthijs Kouwen, Douwe Van Sinderen, Brian McDonnell, Pieter Emiel Verloren Van Themaat, Jennifer Mahony
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Patent number: 10519519Abstract: Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.Type: GrantFiled: July 2, 2018Date of Patent: December 31, 2019Assignee: DSM IP ASSETS B.V.Inventors: Roelof Hendrik Matthijs Kouwen, Pim Van Hee, Douwe Van Sinderen, Brian McDonnell, Jennifer Mahony
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Patent number: 10519516Abstract: The present invention relates to a kit suitable for detection of Streptococcus thermophilus infecting phages, said kit comprising: (a) a first primer pair suitable to generate an amplicon characteristic for a 987 phage; and (b) a second primer pair suitable to generate an amplicon characteristic for a 5093 phage. Further, the present invention relates to a method for detecting the presence of Streptococcus thermophilus infecting phages in a sample.Type: GrantFiled: May 8, 2017Date of Patent: December 31, 2019Assignee: DSM IP ASSETS B.V.Inventors: Roelof Hendrik Matthijs Kouwen, Douwe Van Sinderen, Brian McDonnell
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Publication number: 20190367866Abstract: The present invention relates to a starter culture comprising at least two Streptococcus thermophilus strains, wherein a first and a second Streptococcus thermophilus strain are chosen from RGP group 1, RGP group 2, RGP group 3 and RGP group 4, with the proviso that the first and second Streptococcus thermophilus strains do not belong to the same RGP group.Type: ApplicationFiled: December 14, 2017Publication date: December 5, 2019Inventors: Roelof Hendrik Matthijs KOUWEN, Douwe VAN SINDEREN, Brian MCDONNELL, Pieter Emiel VERLOREN VAN THEMAAT, Jennifer MAHONY
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Patent number: 10244771Abstract: The present invention provides a method for the construction of a bacteriophage-insensitive mutant of a Streptococcus thermophilus parent strain whereby the bacteriophage insensitivity is not based on the CRISPR resistance mechanism but based on another mechanism. The method provides a protocol by which this can be achieved by inactivating one or more of the CRISPR systems present in a given strain. The invention also provides the bacteriophage-insensitive mutants as well as their use in a process for making a dairy product.Type: GrantFiled: July 23, 2015Date of Patent: April 2, 2019Assignee: DSM IP ASSETS B.V.Inventors: Roelof Hendrik Matthijs Kouwen, Laurens Leendert Hanemaaijer, Douwe Van Sinderen, Brian McDonnell, Jennifer Mahony
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Publication number: 20180305777Abstract: Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.Type: ApplicationFiled: July 2, 2018Publication date: October 25, 2018Inventors: Roelof Hendrik Matthijs KOUWEN, Pim Van Hee, Douwe Van Sinderen, Brian McDonnell, Jennifer Mahony
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Patent number: 10041135Abstract: Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.Type: GrantFiled: February 20, 2015Date of Patent: August 7, 2018Assignee: DSM IP ASSETS B.V.Inventors: Roelof Hendrik Matthijs Kouwen, Pim Van Hee, Douwe Van Sinderen, Brian McDonnell, Jennifer Mahony
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Publication number: 20170327912Abstract: The present invention relates to a kit suitable for detection of Streptococcus thermophilus infecting phages, said kit comprising: (a) a first primer pair suitable to generate an amplicon characteristic for a 987 phage; and (b) a second primer pair suitable to generate an amplicon characteristic for a 5093 phage. Further, the present invention relates to a method for detecting the presence of Streptococcus thermophilus infecting phages in a sample.Type: ApplicationFiled: May 8, 2017Publication date: November 16, 2017Inventors: Roelof Hendrik Matthijs Kouwen, Douwe Van Sinderen, Brian McDonnell
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Publication number: 20170218468Abstract: Bacteriophage Insensitive Mutants (BIMs) of three Streptococcus thermophilus parent strains were generated and characterized for phage sensitivity, sedimentation rate, cell chain length, phage adsorption and CRISPR loci alterations. Several BIMs showed an altered sedimentation phenotype as well as an increase cell chain length, reduced phage sensitivity, reduced phage adsorption and 100% identity in three CRISPR loci. The results show that the derived BIMs have become phage-resistant through a mechanism other than CRISPR.Type: ApplicationFiled: February 20, 2015Publication date: August 3, 2017Inventors: Roelof Hendrik Matthijs KOUWEN, Pim VAN HEE, Douwe VAN SINDEREN, Brian MCDONNELL, Jennifer MAHONY
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Publication number: 20170196233Abstract: The present invention provides a method for the construction of a bacteriophage-insensitive mutant of a Streptococcus thermophilus parent strain whereby the bacteriophage insensitivity is not based on the CRISPR resistance mechanism but based on another mechanism. The method provides a protocol by which this can be achieved by inactivating one or more of the CRISPR systems present in a given strain. The invention also provides the bacteriophage-insensitive mutants as well as their use in a process for making a dairy product.Type: ApplicationFiled: July 23, 2015Publication date: July 13, 2017Inventors: Roelof Hendrik Matthijs KOUWEN, Laurens Leendert HANEMAAIJER, Douwe VAN SINDEREN, Brian MCDONNELL, Jennifer MAHONY
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Publication number: 20160381085Abstract: A method for preventing tampering with the accessibility of resources specified by Universal Resource Locators (URLs) comprising establishing a tamper-proof channel between a client and a proxy; requesting URL content via the tamper-proof channel; forwarding URL requests from the proxy; and returning responses to the client via the tamper-proof channel.Type: ApplicationFiled: June 27, 2016Publication date: December 29, 2016Applicant: Pagefair LimitedInventors: Sean Blanchfield, Brian McDonnell, Neil O'Connor, Miles McGuire, Jonathan Frawley
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Publication number: 20160337318Abstract: A method for preventing tampering with the accessibility of resources specified by Universal Resource Locators (URLs) comprising receiving a primary URL from a web server; creating a unique identifier and associating, in a database or by means of encryption, the unique identifier with the received primary URL; creating a secondary URL that includes the unique identifier; and providing the secondary URL to the web server wherein the primary URL is cross referenced to the secondary URL through the unique identifier.Type: ApplicationFiled: July 27, 2016Publication date: November 17, 2016Applicant: PAGEFAIR LIMITEDInventors: Sean BLANCHFIELD, Brian MCDONNELL, Neil O'CONNOR
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Patent number: 9438610Abstract: A method for preventing tampering with the accessibility of resources specified by Universal Resource Locators (URLs) comprising receiving a primary URL from a web server; creating a unique identifier and associating, in a database, the unique identifier with the received primary URL; creating a secondary URL that includes the unique identifier; and providing the secondary URL to the web server wherein the primary URL is cross referenced to the secondary URL through the unique identifier.Type: GrantFiled: September 2, 2014Date of Patent: September 6, 2016Assignee: Pagefair LimitedInventors: Sean Blanchfield, Brian McDonnell, Neil O'Connor
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Publication number: 20160239880Abstract: A method and associated system removes identifiable attributes from displayed advertising content, and instead locates these attributes within the isolated memory area that is accessible only the embedded Javascriptâ„¢. Steps are taken to ensure that the displayed advertising content is correctly formatted, and Javascriptâ„¢ routines are used to emulate the normal interactive functionality of the ad. Because the identifiable attributes of the ad content are now located in the isolated world of the embedded Javascriptâ„¢, it is not possible for a web browser plugin executing in isolated world to access them. In this way, it becomes impossible for an ad blocking tool to automatically identify and remove such advertising content.Type: ApplicationFiled: February 16, 2016Publication date: August 18, 2016Applicant: Pagefair LimitedInventors: Sean BLANCHFIELD, Brian McDONNELL, Neil O'CONNOR, Miles McGUIRE
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Publication number: 20150205809Abstract: Provided are a method and system for displaying an image on a web page, comprising: a fragmentation engine separating a web page element, which when rendered on the web page has visual characteristics, into a plurality of fragments and generating display instructions for each of the fragments; and a rendering engine arranging the fragments on a web page according to the display instructions to replicate the visual characteristics of the web page element.Type: ApplicationFiled: January 9, 2015Publication date: July 23, 2015Applicant: Pagefair LimitedInventors: Sean Blanchfield, Brian McDonnell, Neil O'Connor
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Publication number: 20150082436Abstract: A method for preventing tampering with the accessibility of resources specified by Universal Resource Locators (URLs) comprising receiving a primary URL from a web server; creating a unique identifier and associating, in a database, the unique identifier with the received primary URL; creating a secondary URL that includes the unique identifier; and providing the secondary URL to the web server wherein the primary URL is cross referenced to the secondary URL through the unique identifier.Type: ApplicationFiled: September 2, 2014Publication date: March 19, 2015Applicant: PAGEFAIR LIMITEDInventors: Sean BLANCHFIELD, Brian MCDONNELL, Neil O'CONNOR
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Publication number: 20150053633Abstract: The invention relates to a product supporting roller assembly comprising an elongate spine member and a plurality of rollers, each mounted on the spine member such that the rollers extend outwards on both sides of the spine member. The invention further relates to a product holding unit comprising a plurality of such product supporting roller assemblies. The invention further relates to a method of assembling an axle bearing, which may be used to assembly a product supporting roller assembly, the method comprising positioning a plurality of roller bearings and a roller bearing housing inside a hole, the roller bearings each being connected to a roller bearing holding means and the roller bearings being housed in the roller bearing housing, positioning an axle through the roller bearing housing, and disconnecting the roller bearings from the roller bearing holding means.Type: ApplicationFiled: February 26, 2013Publication date: February 26, 2015Inventor: Brian McDonnell
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Patent number: 5954070Abstract: In accordance with the present invention, there is provided portable fluid application and rinse apparatus for applying a first fluid and for rinsing with a second fluid. A first storage reservoir retains the first fluid and has an outlet. A first application conduit communicates with the outlet of the first storage reservoir. The first application conduit receives the first fluid from the outlet of the first storage reservoir and dispenses the first fluid therethrough. A first drain pan receives the first fluid. A second storage reservoir retains the second fluid and has an inlet and an outlet. A second application conduit communicates with the outlet of the second storage reservoir. The second application conduit receives the second fluid from the outlet of the second storage reservoir and dispenses the second fluid therethrough. A concentration measuring device measures the concentration of the second fluid.Type: GrantFiled: July 31, 1998Date of Patent: September 21, 1999Assignee: Northrop Grumman CorporationInventors: Glen Silva Abad, Ralph Edward Jaffke, Thomas William Jaeger, Brian McDonnell, Rick A. Osterman