Patents by Inventor Brian O. Bachmann
Brian O. Bachmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11312986Abstract: Disclosed are methods of preparing everninomicin analogs by genetic alteration of Micromonospora carbonacea. Everninomicin analogs prepared by these methods and methods of using these analogs to treat infections are also disclose.Type: GrantFiled: June 26, 2020Date of Patent: April 26, 2022Assignee: VANDERBILT UNIVERSITYInventors: Brian O. Bachmann, Emilianne M. Limbrick, Kasia Derewacz
-
Publication number: 20200392553Abstract: Disclosed are methods of preparing everninomicin analogs by genetic alteration of Micromonospora carbonacea. Everninomicin analogs prepared by these methods and methods of using these analogs to treat infections are also disclose.Type: ApplicationFiled: June 26, 2020Publication date: December 17, 2020Inventors: Brian O. BACHMANN, Emilianne M. Limbrick, Kasia Derewacz
-
Patent number: 10696996Abstract: Disclosed are methods of preparing everninomicin analogs by genetic alteration of Micromonospora carbonacea. Everninomicin analogs prepared by these methods and methods of using these analogs to treat infections are also disclosed.Type: GrantFiled: December 9, 2016Date of Patent: June 30, 2020Assignee: Vanderbilt UniveristyInventors: Brian O. Bachmann, Emilianne M. Limbrick, Kasia Derewacz
-
Publication number: 20190093141Abstract: Disclosed are methods of preparing everninomicin analogs by genetic alteration of Micromonospora carbonacea. Everninomicin analogs prepared by these methods and methods of using these analogs to treat infections are also disclosed.Type: ApplicationFiled: December 9, 2016Publication date: March 28, 2019Inventors: Brian O. BACHMANN, Emilianne M. LIMBRICK, Kasia DEREWACZ
-
Patent number: 8134707Abstract: A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization of the laser beam as it passes multiple times through the sample. Interference fringe patterns (28) are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector (34) is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer (38) for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.Type: GrantFiled: October 24, 2005Date of Patent: March 13, 2012Assignee: Vanderbilt UniversityInventors: Darryl J. Bornhop, Stephen Dotson, Brian O. Bachmann
-
Publication number: 20100027008Abstract: A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization or the loser beam as it passes multiple times through the sample. Interference fringe patters (28) are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector (34) is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer (38) for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.Type: ApplicationFiled: October 24, 2005Publication date: February 4, 2010Applicant: VANDERBILT UNIVERSITYInventors: Daryl J. Bornhop, Stephen Dotson, Brian O. Bachmann
-
Publication number: 20090069396Abstract: This invention relates to novel biologically active polyene oxazoles, their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof.Type: ApplicationFiled: November 2, 2007Publication date: March 12, 2009Applicant: THALLION PHARMACEUTICALS, INC.Inventors: James B. McAlpine, Chris M. Farnet, Emmanuel Zazopoulos, Nargis Ismail, Brian O. Bachmann
-
Patent number: 7375088Abstract: This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.Type: GrantFiled: January 21, 2004Date of Patent: May 20, 2008Assignee: Thallion Pharmaceuticals Inc.Inventors: Brian O. Bachmann, James B. McAlpine, Emmanuel Zazopoulos, Chris M. Farnet
-
Patent number: 7312339Abstract: Polyene oxazoles of the following formula wherein R3 is selected from H and methyl, are disclosed. Such compounds, and pharmaceutically acceptable salts thereof, may be used in the inhibition of tumor cell growth. The polyene oxazoles and their pharmaceutically acceptable salts may be formulated as pharmaceutical compositions with pharmaceutically acceptable carriers for use in the inhibition of tumor cells. The polyene oxazoles may be obtained from strains of Streptomyces sparsogenes, such as strain 022 having deposit number IDAC 270504-04.Type: GrantFiled: June 14, 2004Date of Patent: December 25, 2007Assignee: Thallion Pharmaceuticals Inc.Inventors: James B. McAlpine, Chris M. Farnet, Emmanuel Zazopoulos, Nargis Ismail, Brian O. Bachmann
-
Patent number: 7186713Abstract: This invention relates to methods of inhibiting growth of a cancer cell and methods of treating cancer using a novel farnesylated dibenzodiazepinone.Type: GrantFiled: September 27, 2004Date of Patent: March 6, 2007Assignee: Ecopia BioSciences, Inc.Inventors: Chris M. Farnet, Violetta Dimitriadou, Brian O. Bachmann
-
Patent number: 7101872Abstract: This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.Type: GrantFiled: January 21, 2004Date of Patent: September 5, 2006Assignee: Ecopia BioSciences, Inc.Inventors: Brian O. Bachmann, James B. McAlpine, Emmanuel Zazopoulos, Chris M. Farnet, Mahmood Piraee
-
Publication number: 20040266008Abstract: This invention relates to a novel class of linear polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for their production. The compounds may be obtained by cultivation of Streptomyces melanosporafaciens species and isolation of the polyene polyketide, followed by optional chemical production of the isolated polyene polyketide. The compounds may also be produced by other known bacteria. The invention further includes the use of these compounds as inhibitors of fungal cell growth and inhibitors of cancer cell growth. Finally, the invention encompasses pharmaceutical compositions comprising these novel polyketide compounds, or their pharmaceutically acceptable salts or derivatives thereof.Type: ApplicationFiled: May 13, 2004Publication date: December 30, 2004Applicant: Ecopia BioSciences, Inc.Inventors: Brian O. Bachmann, James B. McAlpine, Emmanuel Zazopoulos, Chris M. Farnet
-
Publication number: 20030180766Abstract: The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.Type: ApplicationFiled: January 24, 2003Publication date: September 25, 2003Applicant: Ecopia BioSciences, Inc.Inventors: Chris M. Farnet, Alfredo Staffa, Brian O. Bachmann, James B. McAlpine, Emmanuel Zazopoulos, Zhizi Zhao, Sai Man Wong, Nicolas Desjardins