Patents by Inventor Brian O'Nuallain

Brian O'Nuallain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PSGL-1 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFALMMATORY PHENOTYPES AND USES THEREOF
    Publication number: 20220396632
    Abstract: The present invention is based, in part, on the discovery of anti-PSGL-1 compositions (e.g., monoclonal antibodies and antigen-binding fragments thereof) that regulate myeloid cell inflammatory phenotypes, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-PSGL-1 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
    Type: Application
    Filed: June 2, 2020
    Publication date: December 15, 2022
    Inventors: Tatiana I. Novobrantseva, Igor Feldman, Stephen L. Sazinsky, Joseph A. Wahle, Brian O'Nuallain, Ryan Phennicie
  • ANTI-LRRC25 COMPOSITIONS AND METHODS FOR MODULATING MYELOID CELL INFLAMMATORY PHENOTYPES AND USES THEREOF
    Publication number: 20220363752
    Abstract: The present invention is based, in part, on the discovery of anti-LRRC25 compositions (e.g., monoclonal antibodies and antigen-binding fragments thereof), that regulate inflammatory phenotypes of myeloid cells, such as suppressive myeloid cells, monocytes, macrophages, neutrophils, and/or dendritic cells, including polarization, activation, and/or function, and methods of using such anti-LRRC25 compositions for therapeutic, diagnostic, prognostic, and screening purposes.
    Type: Application
    Filed: June 17, 2020
    Publication date: November 17, 2022
    Inventors: Tatiana I. Novobrantseva, lgor Feldman, Stephen L. Sazinsky, Joseph A. Wahle, Brian O'Nuallain
  • Use of immunoglobulin heavy and light chains or fragments thereof to bind to aggregated amyloidogenic proteins
    Publication number: 20110002945
    Abstract: Subunits of antibodies, such as a light chain or a heavy chain, selectively bind to amyloid fibrils and oligomers.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 6, 2011
    Inventors: Brian O'Nuallain, Scott Dessain, Sharad Adekar
  • Preparation of Purified Covalently Cross-linked Abeta Oligomers and Uses Thereof
    Publication number: 20090246191
    Abstract: The present invention provides a method of purifying cross-linked oligomers. The purified cross-linked oligomers are useful as immunogen for generating and isolating cross-linked oligomer reactive antibodies. The cross-linked oligomer reactive antibodies are useful for detecting amyloid deposition and for diagnosing and treating diseases and conditions associated with amyloid deposition.
    Type: Application
    Filed: October 14, 2008
    Publication date: October 1, 2009
    Applicant: University of Tennessee Research Foundation
    Inventors: Brian O'Nuallain, Alan Solomon, Jonathan S. Wall, Luis Acero, Angela Williams
  • Diagnostic and Therapeutic Potential of Immune Globulin Intravenous (IGIV) Products
    Publication number: 20090232733
    Abstract: The present invention provides IGIV and IGIV enriched for binding to amyloid fibrils and to partially denatured amyloidogenic precursor polypeptides. The present invention also provides methods for obtaining IGIV enriched for binding to amyloid fibrils and to partially denatured amyloidogenic precursor polypeptides. The IGIV recognizes amyloid fibrils and partially denatured amyloidogenic precursor polypeptides. They are useful for treating diseases and conditions associated with amyloid deposition. The IGIV of the present invention also are useful for diagnosing and detecting amyloid deposition.
    Type: Application
    Filed: April 13, 2006
    Publication date: September 17, 2009
    Inventors: Brian O'Nuallain, Rudi Hrncic, Jonathan S. Wall, Alan Solomon