Abstract: The present invention discloses sample thawing devices, systems, and methods, that are configured to take bag-format sample vessels, referred to as “cryobags”, and to thaw the contents of such cryobags. The contents of such cryobags are samples with cells, and the thawing of such samples is based on the temperature, volume, and mass of the sample in order to evenly distribute heat and avoid ice crystallization damage to the cells during thawing. Paired heater plates form an assembly configured to support, clamp, and thaw individual cryobags. The heater plate pair has an articulated member that is repositioning to provide for ease in inserting and removing samples.

Abstract: The present disclosure is related to sample thawing. Features described herein may limit power requirements of the thawing device and may thereby increase the portability of the thawing device. The device may include a housing; a heater block housed within the housing and forming a vial receptacle; a thermally-conductive compliant material may line an inner surface of the receptacle; and a heating element may be coupled with the heater block. The thermally-conductive compliant material may be molded to a shape of a bottom portion of the vial so as to fittingly mate with the bottom portion of the vial. In some embodiments, the heater block does not have moveable components and may be a single non-segmented piece. An ejection pin may be provided configured to break contact between the vial and the thermally-conductive compliant material. Additionally, the receptacle may be localized to the vial region adjacent to the frozen sample.

Abstract: The present invention generally relates to thawing a cryogenically frozen sample. The systems, devices, and methods may be used to heat a sample holder, the sample holder configured to receive a sample container holding the frozen sample. A sample thaw start time may be identified by measuring a temperature of the sample container and/or a temperature of the sample. A sample thaw end time may be calculated as a function of the sample thaw start time. In some embodiments, the same thaw start time may be identified by a significant change in a first derivative of a warming curve of recorded temperature measurements. The sample end time may be calculated by adding a constant to the sample thaw start time. The constant may be the average sample thaw time per the sample container.

Abstract: A system and method for concurrently and uniformly removing thermal energy from clustered specimen samples.

Abstract: A system and method for concurrently and uniformly removing thermal energy from clustered specimen samples.

Abstract: Cryogenic devices are provided in which liquid nitrogen is used to maintain ultra-low temperatures in which samples can be manipulated.

Abstract: Cryogenic devices are provided in which solid carbon dioxide (dry ice) is used to maintain a temperature zone in which samples can be manipulated under conditions in which the sample is maintained at a temperature below ?50 C.

Abstract: The present invention generally relates to thawing a cryogenically frozen sample. The systems, devices, and methods may be used to heat a sample holder, the sample holder configured to receive a sample container holding the frozen sample. A sample thaw start time may be identified by measuring a temperature of the sample container and/or a temperature of the sample. A sample thaw end time may be calculated as a function of the sample thaw start time. In some embodiments, the same thaw start time may be identified by a significant change in a first derivative of a warming curve of recorded temperature measurements. The sample end time may be calculated by adding a constant to the sample thaw start time. The constant may be the average sample thaw time per the sample container.

Abstract: Improved methods for cryopreservation of cells result when cells are cooled at controlled rates in devices that ensure a constant rate of cooling of less than 10° C.

Abstract: Device for gripping cryogenic vials.

Abstract: A portable heat transfer device for transferring thermal energy to and/or from laboratory tubes, clinical vials, specimen vials, laboratory vials, serum vials, drug vials and laboratory containers is provided. The heat transfer device comprises an insulated, thermally conductive heat conduit system and base for the purpose of exchanging heat between the laboratory container and a thermoregulatory device.

Abstract: A system and method for concurrently and uniformly removing thermal energy from clustered specimen samples.

Abstract: Cartridges for maintaining objects at a desired temperature for 100 extended periods of time can be constructed by sealing a thermoconductive 105 cover on a flexible base container filled with a phase change material with a phase change temperature identical to the desired temperature.

Abstract: A portable temperature transfer stand for holding thermo-conductive laboratory devices transferring thermal energy to laboratory devices is provided as well as its methods of use. The temperature transfer stand comprises at least one supporting structure (foot) and a stable stage, both comprising a thermal conductive material. The supporting structure is in direct contact with the stage which is in direct contact with a laboratory device.

Abstract: A system and method for concurrently and uniformly removing thermal energy from a specimen sample. A thermal insulating device is provided comprising an insulating material, the device having a plurality of chambers for receiving specimen samples, the device further includes a thermal ballast whereby the rate of thermal energy removal is controlled and influenced by the thermal ballast.

Abstract: A self-adhesive pad for use in a laboratory setting.

Abstract: A portable temperature transfer device for transferring thermo energy to and/or from a laboratory culture plate is provided as well as its methods of use. The temperature transfer device comprises a base and a raised stage that comprises a thermal conductive material. The raised stage allows direct contact between individual wells of the laboratory culture plate and the temperature transfer device.

Abstract: Methods and systems for cryogenic preservation of cells.

Abstract: Methods and devices can protect samples maintained at controlled temperatures from degradation due to transient temperature fluctuations.