Patents by Inventor Brian Wall
Brian Wall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141175Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: June 26, 2023Publication date: May 2, 2024Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Patent number: 11955117Abstract: A system and method are provided for analyzing and reacting to interactions between entities using electronic communication channels. The method includes receiving, via the communications module, data captured from a conversational exchange between a first entity communicating with a second entity using an electronic communication channel. The method also includes analyzing the captured data to detect an indication that the first entity is or was distracted during the conversational exchange, is or was disinterested in a portion of the conversational exchange or missed the portion of the conversational exchange. The method also includes determining based on the indication an action to address the distraction during, disinterest in, or missing of, the portion of the conversational exchange; and providing, via the communications module, an automated message to at least one of the first entity and the second entity for executing the action.Type: GrantFiled: May 27, 2021Date of Patent: April 9, 2024Assignee: The Toronto-Dominion BankInventors: Bridget McDermid, Brian Bellwood, Natalie Thien Huong Cornwall, Jeffery David True, Ryan Wall, Stella Pui Kwan Chan, Venetia D'Souza, Christopher Michael Arthur Caravan, Pranavan Premathas, Sahifa Habib Qazi, Mah Noor Siddiqui, Joe Moghaizel, Jonathan K. Barnett
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Publication number: 20230324374Abstract: Tandem dyes having internally positioned sensors are provided. Tandem dyes of embodiments of the invention include a peptidic scaffold comprising: one or more donor-fluor amino acid residues each conjugated to a pendant donor fluorophore; one or more acceptor-fluor amino acid residues each conjugated to a pendant acceptor fluorophore; and an internal amino acid residue conjugated to a sensor, e.g., a specific binding member, e.g., for a target analyte. In tandem dyes of embodiments of the invention, the donor and acceptor fluorophores of the are in energy transfer relationship. Also provided are methods of making and using the tandem dyes, as well as kits that include the dyes that find use in embodiments of the methods.Type: ApplicationFiled: March 28, 2023Publication date: October 12, 2023Inventors: Glenn Bartholomew, Brian Wall, David Moureau
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Publication number: 20230295441Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: May 24, 2023Publication date: September 21, 2023Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 11732138Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: September 28, 2022Date of Patent: August 22, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Publication number: 20230235177Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: September 28, 2022Publication date: July 27, 2023Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Patent number: 11702547Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: November 19, 2021Date of Patent: July 18, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20230152327Abstract: Water-soluble dipyrromethene-based dyes are provided herein. In certain cases, the water-soluble dye is a dipyrromethene-boron dye. Embodiments of the subject water-soluble dipyrromethene-based dyes have a narrow absorption maxima in the yellow green range close to or at the 561 nm laser line, and are suitable for use in tandem dye systems. Embodiments of the subject dyes efficiently transfer energy to an acceptor chromophore while a second dipyrromethene-based dye of the same or different chemical structure is within energy-receiving proximity therewith. Also provided herein are tandem dyes that include the subject water-soluble dipyrromethene-based dyes, e.g., as donor chromophores. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: July 28, 2022Publication date: May 18, 2023Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Michel Moureau, Jonathan Hollinger
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Patent number: 11492493Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: December 19, 2018Date of Patent: November 8, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Publication number: 20220348770Abstract: Water-soluble dipyrromethene-based dyes are provided herein. In certain cases, the water-soluble dye is a dipyrromethene-boron dye. Embodiments of the subject water-soluble dipyrromethene-based dyes have a narrow absorption maxima in the yellow green range close to or at the 561 nm laser line, and are suitable for use in tandem dye systems. Embodiments of the subject dyes efficiently transfer energy to an acceptor chromophore while a second dipyrromethene-based dye of the same or different chemical structure is within energy-receiving proximity therewith. Also provided herein are tandem dyes that include the subject water-soluble dipyrromethene-based dyes, e.g., as donor chromophores. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: March 21, 2022Publication date: November 3, 2022Inventors: Glenn Bartholomew, Brian Wall, Jon Hollinger, Yongchao Liang
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Publication number: 20220089877Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: November 19, 2021Publication date: March 24, 2022Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 11214688Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: August 26, 2020Date of Patent: January 4, 2022Assignee: Becton, Dickinson and CompanyInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20200392346Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: August 26, 2020Publication date: December 17, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Patent number: 10844228Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: GrantFiled: March 28, 2019Date of Patent: November 24, 2020Assignee: Becton, Dickinson and CompanyInventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20200002540Abstract: Water soluble light harvesting multichromophores having pendant chromophore groups are provided. The light harvesting multichromophore has a polymeric backbone including non-conjugated repeat units and a plurality of pendant donor chromophore groups linked to a non-conjugated repeat unit of the polymeric backbone. A pendant chromophore group can be a BODIPY group substituted with one or more water soluble groups. Polymeric tandem dyes based on the subject multichromophores are provided that further include an acceptor fluorophore linked to a non-conjugated repeat unit of the polymeric backbone and configured in energy-receiving proximity to a pendant donor chromophore group. Also provided are labelled specific binding members that include the subject polymeric tandem dyes. Methods of evaluating a sample for a target analyte and methods of labelling a target molecule in which the subject polymeric tandem dyes find use are provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: March 28, 2019Publication date: January 2, 2020Inventors: Glenn Bartholomew, Yongchao Liang, Brian Wall, David Moureau
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Publication number: 20190194467Abstract: Water solvated polymeric dyes having a deep ultraviolet excitation spectrum are provided. The subject polymeric dyes include a light harvesting multichromophore having conjugation-modifying repeat units incorporated into the polymer backbone to provide segments of ?-conjugated co-monomers having limited ?-conjugation between segments. Polymeric tandem dyes are also provided that further include a signaling chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject water solvated polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.Type: ApplicationFiled: December 19, 2018Publication date: June 27, 2019Inventors: Yongchao Liang, Jonathan Hollinger, Brian Wall, David Moureau, Lucy Zhao, Glenn P. Bartholomew
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Patent number: 10312873Abstract: Split cascode circuits include multiple cascode paths coupled between voltage supply rails. Each cascode path includes a pair of controllable switches. A feedback path is provided for at least one of the cascode circuit paths. An active load circuit may also have a split cascode structure. Multiple-stage circuits, for implementation in Trans-Impedance Amplifiers (TIAs) or analog Receive Front-End modules (RXFEs), for example, include multiple stages of split cascode circuits.Type: GrantFiled: January 5, 2018Date of Patent: June 4, 2019Assignee: INPHI CORPORATIONInventors: Florin Pera, Stephane Dallaire, Brian Wall
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Patent number: 10122472Abstract: An optical receiver that recovers data is disclosed. The optical receiver includes a photodetector configured to convert an optical signal into a current signal, and a TIA (Transimpedance Amplifier) configured to operate according to a set of parameters to convert the current signal to a voltage signal. The optical receiver also includes an equalizer configured to process the voltage signal to produce a processed signal having recovered data from the optical signal, and to produce one or more equalization metrics. According to an embodiment of the disclosure, the optical receiver has a feedback processor configured to automatically tune operation of the TIA by adjusting at least one of the parameters of the TIA based on the one or more equalization metrics. This may effect a change in performance or power consumption of the optical receiver while receiving and recovering data. A corresponding method for recovering data is also disclosed.Type: GrantFiled: June 28, 2016Date of Patent: November 6, 2018Assignee: INPHI CORPORATIONInventors: Kevin Parker, Lawrence Tse, Kenji Suzuki, Brian Wall, Stephane Dallaire, Florin Pera
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Publication number: 20180145650Abstract: Split cascode circuits include multiple cascode paths coupled between voltage supply rails. Each cascode path includes a pair of controllable switches. A feedback path is provided for at least one of the cascode circuit paths. An active load circuit may also have a split cascode structure. Multiple-stage circuits, for implementation in Trans-Impedance Amplifiers (TIAs) or analog Receive Front-End modules (RXFEs), for example, include multiple stages of split cascode circuits.Type: ApplicationFiled: January 5, 2018Publication date: May 24, 2018Inventors: Florin PERA, Stephane DALLAIRE, Brian WALL
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Patent number: 9899973Abstract: Split cascade circuits include multiple cascade paths coupled between voltage supply rails. Each cascade path includes a pair of controllable switches. A feedback path is provided for at least one of the cascade circuit paths. An active load circuit may also have a split cascade structure. Multiple-stage circuits, for implementation in Trans-Impedance Amplifiers (TIAs) or analog Receive Front-End modules (RXFEs), for example, include multiple stages of split cascade circuits.Type: GrantFiled: March 18, 2016Date of Patent: February 20, 2018Assignee: INPHI CORPORATIONInventors: Florin Pera, Stephane Dallaire, Brian Wall