Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: A bandless orthodontic bracket for a tooth straightening assembly is attachable to the labial or buccal surface of a tooth with a cement. The portion of the bracket adjacent the tooth is provided with at least one undercut recess in which the cement is accommodated so as to provide a "physical" lock between the cement, when set, and the bracket. The frontal portion of the bracket, which is on the reverse side to the labial surface abutting portion, is provided with a smooth bow-shaped channel for accommodating a horizontally disposed arch wire. The arch wire makes contact with the base of the convex channel at one point and permits relative movement with respect to the bracket during mesiodistal tilting of the tooth.