Patents by Inventor Brigham Jay Hartley

Brigham Jay Hartley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR FACILITATING MEMBRANE FUSION AND USES THEREOF
    Publication number: 20240033227
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can fuse to the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Application
    Filed: January 13, 2023
    Publication date: February 1, 2024
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • COMPOSITIONS AND METHODS FOR COMPARTMENT-SPECIFIC CARGO DELIVERY
    Publication number: 20230068547
    Abstract: Fusosome compositions and methods are described herein.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 2, 2023
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Neal Francis Gordon, Jagesh Vijaykumar Shah, Kyle Marvin Trudeau, Brigham Jay Hartley
  • Compositions for facilitating membrane fusion and uses thereof
    Patent number: 11576872
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: February 14, 2023
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • FUSOSOME COMPOSITIONS AND USES THEREOF
    Publication number: 20210228627
    Abstract: The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a re-targeted fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.
    Type: Application
    Filed: May 15, 2019
    Publication date: July 29, 2021
    Inventors: Geoffrey A. von Maltzahn, Jacob Rosenblum Rubens, Michael Travis Mee, John Miles Milwid, Neal Francis Gordon, Jagesh Vijaykumar Shah, Kyle Marvin Trudeau, Brigham Jay Hartley, Peter Anthony Jones
  • CYTOBIOLOGICS AND THERAPEUTIC USES THEREOF
    Publication number: 20210187018
    Abstract: This disclosure provides, e.g., cytobiologic compositions and methods of use thereof. The cytobiologics can be used, e.g., to deliver a protein or nucleic acid to a target cell.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 24, 2021
    Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Jagesh Vijaykumar Shah, Michael Connor, Peter Anthony Jones
  • COMPOSITIONS AND METHODS FOR MEMBRANE PROTEIN DELIVERY
    Publication number: 20210137839
    Abstract: Fusosome compositions and methods are described herein.
    Type: Application
    Filed: February 15, 2019
    Publication date: May 13, 2021
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Jacob Rosenblum Rubens, Michael Travis Mee, Neal Francis Gordon, Jagesh Vijaykumar Shah, Kyle Marvin Trudeau, Brigham Jay Hartley
  • COMPOSITIONS FOR FACILITATING MEMBRANE FUSION AND USES THEREOF
    Publication number: 20200060980
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Application
    Filed: May 8, 2018
    Publication date: February 27, 2020
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin