Abstract: The invention relates to agents for diagnosing and/or treating Lyme disease which contain the antigens of glyceraldehyde-3-phosphate-dehydrogenase (GAPDH), oligopeptide permease, oligopeptide ABC transporter periplasmic BP(oppA-2)(Bb), glycosyl transferase IgtD homologue, heat shock protein 90, VLSE fragment, (U76406) putative v1s rec. casette V1s6 Borrelia burgdorferi, flagellin protein Borrelia garinii, (AE001578) conserved hypothetical protein cp32-6 Borrelia burgdorferi, membrane assoc. protein p66 percursor Borrelia burgdoferii, oligopeptide ABC transporter periplasmic BP (oppA-4)(Bc), fructose-biphosphate aldose (fba) Borrelia burgdorferi, DNAK protein Heat Shock Protein 70 Borrelia burgdorferi, orfE Borrelia burgdorferi, outer surface protein B precursor Borrelia burgdorferi, L-lactate dehydrogenase (ldh), P83/100 gene Borrelia burgdorferi, enolase 2-phosphoglycerate Borrelia burgdorferi, flagellin Protein Borrelia garinii, hypothetical protein BBE28 Borrelia burgdorferi, DNA direct.

Abstract: This invention describes a new analysis and dosing system and a method to manufacture such devices based on the latest microelectronic and micromachining working methods. On chip or wafer 1 which consists of the one- or multilayer substrate 2 and one- or multilayer cover 3, are arranged the essential construction components as reactor 6a, detector 6b, converter/collector 6c, injection valve 6d, micropumps, sensors, and valves V1 to V30, of the system, and the connection(s) to a detecting/metering device. The substrate 2 and/or the cover 3 show depressions 4 to build cavities and the co-operation of the elements 6a . . . 6n.

Abstract: An improved valve arrangement for distributing liquid and/or gaseous subsces from a plurality of substance storing vessels to a processing vessel utilizing fluidic pressure control valves. A common conduit line runs through a block and has an output end connectable to a receiving vessel, the line has a series of openings along one surface of the block. Flexible membranes disposed above the openings of the common conduit line and similar openings in the block surface connected to the supply conduit lines control the fluid communication between the supply conduits and the common conduit.

Abstract: A valve arrangement for distributing liquid and/or gaseous substances from a plurality of substance-storing vessels to a processing vessel. The valve arrangement is characterized by an elongated conduit having an output end connectable to a receiving vessel and a plurality of openings along the length thereof the supply conduits associated with said further openings in the elongated conduit are respectively connectable to substance-storing vessels. Valves are disposed between the supply conduits and the further openings for selectively placing the respective supply conduits in fluid communication with the output end of the elongated conduit.

Abstract: An evacuation device for removing volatile components from a reaction ves of a protein sequenator and requiring connection to a single vacuum pump is provided. The evacuation device includes a vacuum path having a downstream end thereof connectable through a cooling trap to the vacuum pump and an upstream end defining an input. The vacuum path additionally includes a shutoff valve intermediate the length thereof. A further vacuum path bridges the first mentioned vacuum path upstream and downstream of the shutoff valve and has a smaller vacuum cross-section and houses a throttle therein, the second vacuum path being used for generating a prevacuum in response to the closing of the shutoff valve in the first mentioned vacuum path.

Abstract: Method and apparatus for automatically converting of thiazolinone amino acids into phenyl thiohydantoin amino acids as a stage in amino acid sequence analysis of proteins and peptides. According to the invention a solution of thiazolinone amino acids is, under continuous exclusion of oxygen, introduced into a reaction vessel and evaporated to dryness. Then there is added an aqueous trifluoro acetic acid solution or dilute hydrochloric acid, containing a mercaptan, and again evaporated, followed by dissolving of the residue in a mixture of dichloroethane and methanol.