Abstract: Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

Abstract: Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

Abstract: A system for determining directed media for a user is provided. The exemplary system comprises a media selection optimizer which is configured to determine a directed media component based on a user profile associated, via a device identifier, with a network access device. The media selection optimizer may also utilize access point information, historic information, and access point location-centric information in its determination of the directed media component. The directed media component may then be forward to a media server which provides the corresponding directed media to the user. The directed media may comprise advertisement, coupons, video, music, or any other media which is customizable to the user.

Abstract: A system for determining directed media for a user is provided. The exemplary system comprises a media selection optimizer which is configured to determine a directed media component based on a user profile associated, via a device identifier, with a network access device. The media selection optimizer may also utilize access point information, historic information, and access point location-centric information in its determination of the directed media component. The directed media component may then be forward to a media server which provides the corresponding directed media to the user. The directed media may comprise advertisement, coupons, video, music, or any other media which is customizable to the user.

Abstract: Embodiments of a system and method for network operation and information processing, including user engagement and profiling features are described. A method includes transmitting a request for authorization to use a public-access network from a computer, including, with the request, identifier information regarding the user. Data including additional information, such as a terms and conditions page, a splash page, relevant information based on user-specific information such as user location, and other like information is then transmitted over the network. The data to be transmitted is determined by processing software as a function of the identifier information regarding the user. A network connection is then opened up for the user of the computer.

Abstract: A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

Abstract: According to some embodiments of the present invention, a system, apparatus and method of network operation and information processing, including data acquisition, data processing, data provision, and/or data interoperability features is presented. In some exemplary embodiments, the method includes registering users logging-on to a computer network and gathering user-related information from users. In one or more embodiments, user-profile and location-centric information for each user may be gathered and/or processed in connection with processing targeting and content information.

Abstract: According to some embodiments of the present invention, a system (100), apparatus and method of network operation and information processing, including data acquisition, data processing, data provision, and/or data interoperability features is presented. In some exemplary embodiments, the method includes registering users logging-on to a computer network (170) and gathering user-related information from users (121). In one or more embodiments, user-profile and location-centric information for each user may be gathered and/or processed in connection with processing targeting and content information.

Abstract: A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

Abstract: According to some embodiments of the present invention, a system, apparatus and method for targeted content delivery is presented. In some embodiments, the method comprises registering users logging-on to a computer network and gathering user-related information from users. Location-centric information for each user logged-on to the network is relayed to a server, and user-profile information for each user is retrieved from a database. User-profile and location-centric information for each user is processed to get targeting information for each user and the targeting information is sent to a content-provider wherein the content-provider uses the targeting information to select content to be displayed to each user. In some embodiments, user-profile and location-centric information may be gathered from wireless access points to which users log-on in order to access the Internet.

Abstract: A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.

Abstract: Systems and methods are disclosed for network operation and information processing involving engaging users of a network. In one exemplary embodiment, there is provided a method of engaging users of a public-access network. Moreover, the method includes associating a processing component with the public-access network; transmitting a request for authorization to use the public-access network, including transmission of a specific identifier associated with the user; transmitting first data including data determined by processing software as a function of the specific identifier; and opening up a connection to the network for the user. In one or more further embodiments, the specific identifier may include or be a function of a processing component ID or the MAC address of a device associated with the user. Other exemplary embodiments may include building profiles of users who access the network based on information collected.

Abstract: Systems and methods are disclosed for network operation and information processing involving engaging users of a network. In one exemplary embodiment, there is provided a method of engaging users of a public-access network. Moreover, the method includes associating a processing component with the public-access network; transmitting a request for authorization to use the public-access network, including transmission of a specific identifier associated with the user; transmitting first data including data determined by processing software as a function of the specific identifier; and opening up a connection to the network for the user. In one or more further embodiments, the specific identifier may include or be a function of a processing component ID or the MAC address of a device associated with the user. Other exemplary embodiments may include building profiles of users who access the network based on information collected.

Abstract: Systems and methods are disclosed for network operation and information processing involving engaging users of a network. In one exemplary embodiment, there is provided a method of engaging users of a public-access network. Moreover, the method includes associating a processing component with the public-access network; transmitting a request for authorization to use the public-access network, including transmission of a specific identifier associated with the user; transmitting first data including data determined by processing software as a function of the specific identifier; and opening up a connection to the network for the user. In one or more further embodiments, the specific identifier may include or be a function of a processing component ID or the MAC address of a device associated with the user. Other exemplary embodiments may include building profiles of users who access the network based on information collected.

Abstract: Systems and methods are disclosed for network operation and information processing involving engaging users of a network. In one exemplary embodiment, there is provided a method of engaging users of a public-access network. Moreover, the method includes associating a processing component with the public-access network; transmitting a request for authorization to use the public-access network, including transmission of a specific identifier associated with the user; transmitting first data including data determined by processing software as a function of the specific identifier; and opening up a connection to the network for the user. In one or more further embodiments, the specific identifier may include or be a function of a processing component ID or the MAC address of a device associated with the user. Other exemplary embodiments may include building profiles of users who access the network based on information collected.

Abstract: Systems and methods for developing customer relationships with a network access point are provided. In exemplary embodiments, access information and a device identifier is received from an access point. The access information and device identifier may be stored within a device record. A user profile is generated using at least some of the information contained within the device record. A user preference is then provided to identify and maintain relationships with users. The user preference can comprise at least some of the user profile.

Abstract: A system for determining directed media for a user is provided. The exemplary system comprises a media selection optimizer which is configured to determine a directed media component based on a user profile associated, via a device identifier, with a network access device. The media selection optimizer may also utilize access point information, historic information, and access point location-centric information in its determination of the directed media component. The directed media component may then be forward to a media server which provides the corresponding directed media to the user. The directed media may comprise advertisement, coupons, video, music, or any other media which is customizable to the user.