Abstract: An assembly, comprising a catheter hub defining a hub cavity extending axially between proximal and distal ends of the catheter hub, a female luer connector extending from within the proximal end of the catheter hub, a catheter tube extending from within the distal end of the catheter hub and a pinch valve body axially movable in the hub cavity and defining a valve conduit that fluidly connects the female luer connector and the catheter tube, wherein the pinch valve body has a distal end sheathed over the catheter tube, and a proximal end comprising proximal and distal pinch valves, wherein the female luer connector has internal pinch surfaces configured so that axial movement of the pinch valve body in the hub cavity positively opens and closes the proximal and distal pinch valves in predetermined succession or order as either a needle is proximally withdrawn from the catheter tube, or a male luer connector is distally inserted into, or proximally withdrawn from, the female luer connector.