Patents by Inventor Brooke Bullock LAO

Brooke Bullock LAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression
    Patent number: 11560359
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: January 24, 2023
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Richard Bonneau, Kevin Drew
  • Oxopiperazine helix mimetics as inhibitors of the p53-MDM2 interaction
    Patent number: 11180481
    Abstract: The present invention relates to oligooxopiperazines for modulating the p53-Mdm2 interaction. Exemplary oligooxopiperazines include those of Formula IA, Formula IB, and Formula IC below (wherein the various substituents are as defined herein). Methods of using the oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 23, 2021
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Danielle Guarracino, Richard Bonneau, Kevin Drew
  • OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION
    Publication number: 20210171473
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: August 3, 2020
    Publication date: June 10, 2021
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Richard BONNEAU, Kevin DREW
  • Oxopiperazine helix mimetics for control of Hypoxia-Inducible gene expression
    Patent number: 10787424
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: September 29, 2020
    Assignee: NEW YORK UNIVERSITY
    Inventors: Paramjit S. Arora, Brooke Bullock Lao, Richard Bonneau, Kevin Drew
  • PUMP SPRAY OR PRESSURIZED AEROSOL DEVICE WITH APPLICATOR ARM
    Publication number: 20200086097
    Abstract: A spray device for dispensing a product includes a canister, a wand attached to the canister by a ball joint, a manually actuatable valve connecting the canister to the wand for dispensing a product through a nozzle at a free end of the valve. The wand may be telescoping. Applicator attachments are provided for securing to the free end of the wand for varying the delivery.
    Type: Application
    Filed: December 13, 2017
    Publication date: March 19, 2020
    Inventors: Brooke Bullock Lao, Andrew Mahon
  • Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
    Patent number: 9783526
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 10, 2017
    Assignee: New York University
    Inventors: Paramjit S. Arora, Brooke Bullock Lao
  • OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION
    Publication number: 20170190673
    Abstract: The present invention relates to oxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF1?. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF1a with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: May 20, 2015
    Publication date: July 6, 2017
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Richard BONNEAU, Kevin DREW
  • Oligooxopiperazines and methods of making and using them
    Patent number: 9624203
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: April 18, 2017
    Assignee: New York University
    Inventors: Paramjit S. Arora, Petra To{hacek over (s)}ovská, Danielle Guarracino, Brooke Bullock Lao
  • OXOPIPERAZINE HELIX MIMETICS AS INHIBITORS OF THE p53-MDM2 INTERACTION
    Publication number: 20170037033
    Abstract: The present invention relates to oligooxopiperzines for modulating the p53-Mdm2 interaction. Methods of using the oligooxopiperazines are also disclosed.
    Type: Application
    Filed: April 15, 2015
    Publication date: February 9, 2017
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Danielle GUARRACINO, Richard BONNEAU, Kevin DREW
  • CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS
    Publication number: 20160297802
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: February 8, 2016
    Publication date: October 13, 2016
    Applicants: New York University, University of Southern California
    Inventors: Paramjit S. ARORA, Bogdan Z. Olenyuk, Brooke Bullock Lao, Ivan Grishagin
  • OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
    Publication number: 20160214965
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Application
    Filed: April 11, 2016
    Publication date: July 28, 2016
    Inventors: Paramjit S. ARORA, Petra TOSOVSKÁ, Danielle GUARRACINO, Brooke Bullock LAO
  • Oligooxopiperazines and methods of making and using them
    Patent number: 9309230
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: April 12, 2016
    Assignee: New York University
    Inventors: Paramjit S. Arora, Petra To{hacek over (s)}ovská, Danielle Guarracino, Brooke Bullock Lao
  • OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM
    Publication number: 20150072991
    Abstract: The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.
    Type: Application
    Filed: June 13, 2014
    Publication date: March 12, 2015
    Applicant: NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Petra TOSOVSKÁ, Danielle GUARRACINO, Brooke Bullock LAO
  • INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES
    Publication number: 20150065436
    Abstract: The present invention relates to peptidomimetics that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Methods of using the peptidomimetics to, e.g., inhibit the HIF-1?-p300/CBP interaction, are also disclosed.
    Type: Application
    Filed: September 3, 2014
    Publication date: March 5, 2015
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, NEW YORK UNIVERSITY
    Inventors: Paramjit S. ARORA, Brooke Bullock LAO, Laura K. HENCHEY, Nathaniel J. TRAASETH, Paul THOMSON, Swati KUSHAL, Bogdan Z. OLENYUK