Patents by Inventor Brooke Bullock Lau

Brooke Bullock Lau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics
    Patent number: 9255086
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: February 9, 2016
    Assignees: New York University, University of Southern California
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Brooke Bullock Lau, Ivan Grishagin
  • CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH OLIGOOXOPIPERAZINE NONPEPTIDIC HELIX MIMETICS
    Publication number: 20150018364
    Abstract: The present invention relates to oligooxopiperazines that mimic helix ?B of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these oligooxopiperazines and methods of using these oligooxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation).
    Type: Application
    Filed: February 19, 2013
    Publication date: January 15, 2015
    Applicants: NEW YORK UNIVERSITY, UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Brooke Bullock Lau, Ivan Grishagin