Abstract: Metal particulates capable of generating low levels of corrosion current beneficial for pharmaceutical, cosmetic and other medical uses are provided.

Abstract: Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.

Abstract: A novel combination of a suture anchor and a bone void filler composition. Also, a method of using the combination to affix soft tissue to mount a suture anchor in a bone.

Abstract: Novel biodegradable bone void filler compositions. The bone void filler compositions have a biodegradable material component, an osteoconductive component, and a therapeutic agent. The bone void filler optionally contains an osteoinductive component. Also disclosed is a method of using the bone void filler compositions to fill a bone void.

Abstract: Methods and compositions for producing therapeutic agents using chondrocytes are provided. The genetically engineered chondrocytes can be used to express the therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.

Abstract: A dental implant for osseointegration in alveolar bone. The implant includes at least three different and distinct surface regions.

Abstract: A dental implant (10) for osseointegration in alveolar bone. The implant includes an annular shoulder (18) and a plurality of splines (32) extending axially therefrom for interdigitated engagement with similar splines of an abutment for supporting a tooth prosthesis. The bone-engaging surface (22) of the implant includes a biocompatible porous metal surface (24) into which bone can grow, an intermediate non-porous, rough, biocompatible metal surface (26) to which bone can attach that is located between the porous surface and the annular shoulder, and a smooth, non-porous biocompatible metal surface (28) located between the intermediate surface and the annular shoulder.

Abstract: An implant and a process for treating the same wherein the implant has a highly pure coating of crystalline hydroxylapatite (HA). The implant is initially coated with HA using a plasma spraying technique and is then subjected to a two stage process, including a hydrothermal treatment stage and a leaching stage. The resulting implant is highly crystalline, containing only a small percentage of amorphous calcium phosphate and essentially being free of calcium hydroxide, calcium oxide, and calcium carbonate.