Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: The present Invention relates to a pellet comprising melatonin and methods of treating insomnia.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: Disclosed are embodiments of a dough proofer for a commercial bakery that can receive dough pieces from a dough divider onto trays. Each tray has cups that hold dough pieces. The trays are moved through the proofer by a conveyor system. The proofer has a checkweigher. The checkweigher also uses the same conveyor system and has (1) a tray tipper that tips a tray of dough pieces to make the dough pieces fall out of the tray; (2) a row of gates under the tray to receive and hold the dough pieces and release the dough pieces so that they fall back into their original cups and tray; (3) a row of load cells associated with gates that produces weight data indicative of dough piece weights; and (4) a controller that controls the divider based upon the weight data so that the dough pieces exhibit a substantially uniform target weight.

Abstract: A machine that automatically performs select tests on candles includes a pedestal onto which a candle is positioned. The machine also includes cameras, focused on the candle, to collect thermal emission and visual data resulting from a “candle burn”. The machine is used in a “candle burn” test method.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: A method for treating obesity in a patient, the method comprising administering a dose of a GLP1 agonist to the patient in a treatment regimen effective to manage the patient's satiety and thereby effect a reduction in the patient's weight; and, in conjunction with the administration of the dose of GLP1 agonist, engaging in a directed digital therapeutic program that manages patient weight loss and the treatment regimen for the GLP1 agonist with the objective of achieving a predetermined target weight for the patient, wherein the patient achieves the target weight.

Abstract: There is a dosage regimen for amlodipine for use in the treatment of hypertension.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include creating a variant control profile for the CCPP for a power plant model of the CCPP. The method may include modifying the variant control profile in response to the variant control profile not reducing the fuel consumption or meeting the quality threshold. The method may also include adjusting the CCPP to use the variant control profile in response to the variant control profile reducing the fuel consumption and meeting the quality threshold. Using the variant control profile adjusts a turbine section inlet temperature schedule or an exhaust temperature schedule for the CCPP.

Abstract: A method, apparatus, and system for leak detection in a distribution network having consumption meters. The distribution network is divided into zones having an upstream location and a downstream location. An upstream pressure sensor detects the upstream pressure at the upstream location and the downstream pressure sensor detects the detected downstream pressure at the downstream location. A downstream pressure lookup table is used to determine an expected pressure at each downstream location based on a range of hypothetical upstream pressures at the corresponding upstream location and consumption data from the consumption meters. The expected pressure and the detected downstream pressure at each downstream location are compared to determine if the calculated discrepancy exceeds a discrepancy threshold.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include creating a variant control profile for the CCPP for a power plant model of the CCPP. The method may include modifying the variant control profile in response to the variant control profile not reducing the fuel consumption or meeting the quality threshold. The method may also include adjusting the CCPP to use the variant control profile in response to the variant control profile reducing the fuel consumption and meeting the quality threshold. Using the variant control profile adjusts a turbine section inlet temperature schedule or an exhaust temperature schedule for the CCPP.

Abstract: Embodiments of the disclosure provide a method for operating a combined cycle power plant (CCPP). The method may include generating a power plant model for operating the CCPP, determining whether at least two gas turbines in the power plant model generate a power output, and modeling a fuel consumption of the CCPP for a baseline split ratio between the at least two gas turbines. The method may also include determining whether the variant split ratio meets a quality threshold for the CCPP, and adjusting the CCPP to use the variant split ratio in response to the variant split ratio meeting the quality threshold.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: A forward concave trapezoidal seating system and methods are presented. Trapezoidal seats comprise a front side smaller than a rear side. The trapezoidal seats are aligned in a forward arc from a straight seat to a most-angled seat. A straight side of the straight seat is configured to substantially align with a center line of an aircraft fuselage. A most-angled side of the most-angled seat is angled inboard relative to the straight side, and the most-angled seat is outboard of the straight seat. A side unit is coupled to the most-angled side and supports the trapezoidal seats.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: A housing assembly includes a housing, a printed circuit board (PCB) contained in a housing, and a cup-shaped cap having an interior and a flange portion. A tall component extending from the PCB is covered by the cap such that the tall component is disposed in the interior of the cap and the flange portion of the cap engages the PCB. A vacuum is applied and while maintaining the vacuum, an encapsulant is introduced into the housing to a level so as to cover the PCB and certain other components not the relatively taller component(s). When the vacuum is released, a pressure differential between the environmental pressure and the vacuum remaining in the cap interior forces encapsulant into the cap interior to a level higher than that outside of the cap. A multi-level height potting process is achieved.

Abstract: A housing assembly includes a housing, a printed circuit board (PCB) contained in a housing, and a cup-shaped cap having an interior and a flange portion. A tall component extending from the PCB is covered by the cap such that the tall component is disposed in the interior of the cap and the flange portion of the cap engages the PCB. A vacuum is applied and while maintaining the vacuum, an encapsulant is introduced into the housing to a level so as to cover the PCB and certain other components not the relatively taller component(s). When the vacuum is released, a pressure differential between the environmental pressure and the vacuum remaining in the cap interior forces encapsulant into the cap interior to a level higher than that outside of the cap. A multi-level height potting process is achieved.

Abstract: Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3.

Abstract: The present invention relates to medicaments based on oligomeric forms of 3-hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1 and 2.

Abstract: A method, apparatus, and system for leak detection in a distribution network having consumption meters. The distribution network is divided into zones having an upstream location and a downstream location. An upstream pressure sensor detects the upstream pressure at the upstream location and the downstream pressure sensor detects the detected downstream pressure at the downstream location. A downstream pressure lookup table is used to determine an expected pressure at each downstream location based on a range of hypothetical upstream pressures at the corresponding upstream location and consumption data from the consumption meters. The expected pressure and the detected downstream pressure at each downstream location are compared to determine if the calculated discrepancy exceeds a discrepancy threshold.