Patents by Inventor Bruce D. Quimby
Bruce D. Quimby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210305036Abstract: Provided herein is an ion source containing a plurality of components, at least one of which is partially coated with a layer of silicon. The ion source reduces reactivity between the sample and the carrier gas, reduces or eliminates tailing in ion chromatograms, and/or improves mass spectral fidelity. Also provided are methods of using the ion source in a mass spectrometer or gas chromatograph-mass spectrometer.Type: ApplicationFiled: March 26, 2020Publication date: September 30, 2021Inventors: Bruce D. Quimby, Anastasia A. Andrianova
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Patent number: 8513593Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.Type: GrantFiled: December 17, 2012Date of Patent: August 20, 2013Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Michael J. Szelewski, Michael K. Freed, Harry F. Prest
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Publication number: 20130062515Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.Type: ApplicationFiled: September 9, 2011Publication date: March 14, 2013Applicant: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Harry F. Prest, Michael J. Szelewski, Michael K. Freed
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Patent number: 8378293Abstract: In a mass spectrometer or gas chromatograph/mass spectrometer system, a conditioning gas such as, for example, hydrogen is added to condition or clean one or more components or regions of the mass spectrometer such as the ion source. The conditioning gas may be added upstream of the mass spectrometer such as, for example, into a sample inlet or a chromatographic column, or may be added directly into the mass spectrometer. The conditioning gas may be added off-line, when the mass spectrometer is not analyzing a sample, or on-line during sample analysis. When added on-line, the conditioning gas may be mixed with a carrier gas such as, for example, helium. In another embodiment, the conditioning gas also serves as the carrier gas through the column; another gas such as, for example, helium may be added to the carrier gas stream.Type: GrantFiled: September 9, 2011Date of Patent: February 19, 2013Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Harry F. Prest, Michael J. Szelewski, Michael K. Freed
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Publication number: 20120318970Abstract: Systems and methods for mass spectrometry are presented. In one embodiment, a method for selecting a target ion and a plurality of qualifier ions for calibration of an analyte in an MS test is presented. For example, the method may include: (a) obtaining a reference spectrum for the analyte; (b) identifying an extraction time window for the reference spectrum; (c) extracting a matrix spectrum over the extraction time window; (d) measuring a noise value in a plurality of matrix ions; (e) calculating a signal-to-noise value for a plurality of analyte ions by dividing the abundance of the analyte ion by the noise value at a corresponding matrix ion; (f) assigning the target ion as the analyte ion having the highest signal-to-noise value; and (g) assigning a qualifier ion as the analyte ion with the next highest signal-to-noise value.Type: ApplicationFiled: June 15, 2011Publication date: December 20, 2012Inventors: Bruce D. Quimby, Michael J. Szelewski
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Patent number: 7507336Abstract: A connector element for use with analytical devices is provided. The connector element includes a cavity for receiving a sealing member, and an access element for providing access to the sealing member when disposed in the cavity, e.g., for dislodging the sealing member from the connector element. Also provided are analytical devices that include the connector element, as well as methods of using the same.Type: GrantFiled: April 20, 2005Date of Patent: March 24, 2009Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Wesley M. Norman
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Patent number: 7258132Abstract: An electronically controlled back pressure regulator comprises an analysis device having a vent coupled to the analysis device through a vent path, a pressure sensor coupled to the vent path, a proportional valve coupled to the vent path, the proportional valve configured to controllably alter pressure in the analysis device, and an electronically controlled closed-loop controller configured to control a flow through the vent based on a signal from the pressure sensor and an electronically controlled pressure setpoint.Type: GrantFiled: June 18, 2004Date of Patent: August 21, 2007Assignee: Agilent Technologies, Inc.Inventors: Robert Clark Henderson, Bruce D. Quimby
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Patent number: 6915227Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: GrantFiled: November 26, 2003Date of Patent: July 5, 2005Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Publication number: 20040122611Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: ApplicationFiled: November 26, 2003Publication date: June 24, 2004Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Patent number: 6691053Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: GrantFiled: November 30, 2001Date of Patent: February 10, 2004Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Publication number: 20030110000Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: ApplicationFiled: November 30, 2001Publication date: June 12, 2003Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Patent number: 6493639Abstract: A preferred method for identifying analytes of samples by utilizing chemometric analysis for interpreting chromatographic data obtained under locked conditions includes the steps of: (1) providing a locking GC system which includes a column operated at a column head pressure; (2) adjusting the column head pressure of the locking GC system so that a column void time of the column in the locking GC system, when a known analyte is eluted therethrough, is matched with the column void time of the column in a reference GC system, when the known analyte is eluted therethrough; (3) analyzing the sample with the locking GC system so that chromatographic data corresponding to the sample is compiled, and; (4) performing chemometric analysis on the chromatographic data.Type: GrantFiled: May 16, 2000Date of Patent: December 10, 2002Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Bruce D. Quimby
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Patent number: 6153438Abstract: A method for identifying analytes of interest by referencing to a retention factor database corresponding to a plurality of identified analytes that is independent of column dimensions and carrier gas type while dependent upon stationary phase type ratio and a relative temperature program. The retention factor database is generated on a reference GC system in which the column head pressure is adjusted to ensure high reproducibility of retention times by locking the column void time and/or the retention time of an identified analyte to a specific value such that accurate retention factors (k) can be calculated in accordance with the formula: ##EQU1## where VT is the void time of the column having a specified stationary phase and phase coating installed in a GC system operating in accordance to a specified temperature program (where time is expressed in units of column void time).Type: GrantFiled: May 20, 1997Date of Patent: November 28, 2000Assignee: Hewlett-Packard CompanyInventors: Leonid M. Blumberg, Bruce D. Quimby, Matthew S. Klee
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Patent number: 6112161Abstract: A method, apparatus, and article of manufacture for enhanced integration of signals, such as those generated by chromatographs. In one embodiment an approximate baseline used for integration of a signal is improved to reduce error. Alternate embodiments filter drift, noise, or both from a signal prior to integration or simulated distillation. The signals are processed according to a computer program stored in a memory. The methods include steps for subtracting an approximate baseline from the signal, defining a noise band in the resulting difference, and forming a composite baseline by substituting signal data for baseline data wherever the difference does not exceed the threshold, thus leaving the parts of the approximate baseline that correspond to signal peaks unchanged.Type: GrantFiled: September 17, 1997Date of Patent: August 29, 2000Assignee: Hewlett-PackardInventors: Paul C. Dryden, Bruce D. Quimby
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Patent number: 5987959Abstract: The invention provides a method for automated matching of retention times obtained using a known chromatographic method having a defined set of column parameters and operating parameters to the retention times obtained using a new chromatographic method having a new set of column parameters, wherein the retention times of components separated in accordance with the new chromatographic method are matched to the retention times set forth in the known chromatographic methods. A procedure is described to adjust head pressure to compensate for differences in a new versus the original column, carrier gas, and column outlet pressure of the known method.Type: GrantFiled: March 6, 1998Date of Patent: November 23, 1999Assignee: Hewlett-Packard CompanyInventors: Matthew S. Klee, Bruce D. Quimby, Leonid M. Blumberg
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Patent number: 5827946Abstract: The invention provides a method for developing a retention time database of identified analytes and their respective retention times in a reference Gas Chromatograph (GC) system under locked conditions for identification of unknown analytes of interest eluting from any GC system locked to the retention time database and may also be employed in combination with selective detection and or method translation for enhanced certainty of identification.Type: GrantFiled: April 30, 1997Date of Patent: October 27, 1998Assignee: Hewlett-Packard CompanyInventors: Matthew S. Klee, Philip L. Wylie, Bruce D. Quimby, Leonid M. Blumberg
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Patent number: 5151371Abstract: The oxygen-selectivity of an atomic emission detection system is enhanced by introducing a carbon-containing, preferably non-oxygenated, gas as a portion of the reagent gas. In preferred embodiments, the reagent gas is nitrogen and/or hydrogen and up to about 50 volume percent of a C.sub.1 -C.sub.4 hydrocarbon gas.Type: GrantFiled: August 14, 1989Date of Patent: September 29, 1992Assignee: Hewlett-Packard CompanyInventors: Bruce D. Quimby, James J. Sullivan
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Patent number: 4776690Abstract: The nitrogen-selectivity of an atomic emission detection system is enhanced by use, as the reagent gas, of a single gas or a mixture of gas components containing oxygen and hydrogen in an oxygen/hydrogen molar ratio of about 1:10 to 10:1.Type: GrantFiled: October 5, 1987Date of Patent: October 11, 1988Assignee: Hewlett-Packard CompanyInventor: Bruce D. Quimby
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Patent number: 4654504Abstract: The radio frequency powered gas discharge tube of an atomic emission detector is cooled with a flow of liquid, and means are provided for grounding points in the flow that are on opposite sides of the radio frequency field so as to reduce the amount of radio frequency energy escaping from the discharge tube in the liquid.Type: GrantFiled: November 30, 1983Date of Patent: March 31, 1987Assignee: Hewlett-Packard CompanyInventors: James J. Sullivan, Bruce D. Quimby
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Patent number: D576897Type: GrantFiled: December 21, 2007Date of Patent: September 16, 2008Assignee: Agilent Technologies Inc.Inventors: Bruce D. Quimby, Joseph B. Bush, Robert D. Ricker, Thomas M. Logan, Viet X. Nguyen, Alvin D. Schmidt, Glenn Thomas, David Hubbard, Joseph Spalding, Paul J. Powell, Jr.