Patents by Inventor Bruce Irvine

Bruce Irvine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11479747
    Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 25, 2022
    Assignee: CLAREMONT BIOSOLUTIONS LLC
    Inventors: Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling
  • Patent number: 11473049
    Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: October 18, 2022
    Assignee: CLAREMONT BIOSOLUTIONS, LLC
    Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
  • Publication number: 20210306391
    Abstract: A system includes one or more computing devices communicatively coupled to one or more sports content sources. The one or more computing devices are further coupled to multiple sports-content outlet entities. The one or more computing devices are configured to provide sports content from the one or more sources to the outlet entities.
    Type: Application
    Filed: March 31, 2021
    Publication date: September 30, 2021
    Inventors: Warren Rodie, Bruce Irvine, Gavin Smith
  • Publication number: 20200010789
    Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).
    Type: Application
    Filed: February 1, 2018
    Publication date: January 9, 2020
    Inventors: Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling
  • Publication number: 20200002663
    Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 2, 2020
    Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
  • Patent number: 10428301
    Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: October 1, 2019
    Assignee: Keck Graduate Institute
    Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
  • Patent number: 9873860
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Heating may be used. Lysing may be performed in a flow through apparatus.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: January 23, 2018
    Assignee: CLAREMONT BIOSOLUTIONS LLC
    Inventors: Bruce Irvine, Robert W. Doebler, Ryan P. Talbot
  • Patent number: 9677968
    Abstract: Within examples, remotely controlled and thermally managed systems for actuation of components in a wind tunnel model are described. A wind tunnel test environment may provide ambient to cryogenic temperature conditions to reproduce aerodynamic flight Reynolds number conditions. Example systems comprise a modular test assembly mounted on a test component, and the test component includes at least one movable surface and is configured for placement in the wind tunnel. An actuator is included within the modular test assembly and coupled to the at least one movable surface of the test component, and a temperature sensor is included to provide temperature of an exterior of the modular test assembly. In addition, a controller is in communication with the actuator and the temperature sensor, and is configured to remotely cause the actuator to move the at least one movable surface through a range of motion.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: June 13, 2017
    Assignee: The Boeing Company
    Inventors: Robert C. Griffiths, James Henry Mabe, Stefan Bieniawski, Frederick Calkins, Jonathan K. Brown, Ordie Dean Butterfield, Frank Bruce Irvine
  • Publication number: 20170037359
    Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 9, 2017
    Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
  • Publication number: 20170003194
    Abstract: Within examples, remotely controlled and thermally managed systems for actuation of components in a wind tunnel model are described. A wind tunnel test environment may provide ambient to cryogenic temperature conditions to reproduce aerodynamic flight Reynolds number conditions. Example systems comprise a modular test assembly mounted on a test component, and the test component includes at least one movable surface and is configured for placement in the wind tunnel. An actuator is included within the modular test assembly and coupled to the at least one movable surface of the test component, and a temperature sensor is included to provide temperature of an exterior of the modular test assembly. In addition, a controller is in communication with the actuator and the temperature sensor, and is configured to remotely cause the actuator to move the at least one movable surface through a range of motion.
    Type: Application
    Filed: June 30, 2015
    Publication date: January 5, 2017
    Inventors: Robert C. Griffiths, James Henry Mabe, Stefan Bieniawski, Frederick Calkins, Jonathan K. Brown, Ordie Dean Butterfield, Frank Bruce Irvine
  • Patent number: 9428725
    Abstract: A flow-through device for capturing a biological material from a fluid specimen and lysing the fluid specimen. The flow through device may include a first chamber containing a portion of the fluid specimen and a solid phase material retained in the first chamber. The solid phase material may have an affinity for the biological material in the fluid specimen. The first chamber may include an inlet opening which allows flow of the fluid specimen into the first chamber. The first chamber may also include an outlet opening which allows flow of the fluid specimen out of the first chamber. The flow through device may include a second chamber fluidly connected to the first chamber. The second chamber may include a portion of the fluid specimen and an impeller. The impeller may in use impart rotational motion to the fluid specimen to mechanically lyse the fluid specimen.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: August 30, 2016
    Assignee: Claremont Biosolutions LLC
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Publication number: 20160186127
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Heating may be used. Lysing may be performed in a flow through apparatus.
    Type: Application
    Filed: January 12, 2016
    Publication date: June 30, 2016
    Inventors: Bruce Irvine, Robert W. Doebler, Ryan P. Talbot
  • Patent number: 9260475
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Heating may be used. Lysing may be performed in a flow through apparatus.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: February 16, 2016
    Assignee: Claremont BioSolutions LLC
    Inventors: Bruce Irvine, Robert W. Doebler, Barbara Erwin, Ryan P. Talbot, Angelika Brigitte Niemz
  • Publication number: 20150024480
    Abstract: Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.
    Type: Application
    Filed: August 4, 2014
    Publication date: January 22, 2015
    Inventors: Robert Doebler, Ali Nadim, James D. Sterling, Anna Hickerson, Barbara Erwin, Denice Woyski, Ryan P. Talbot, Bruce Irvine
  • Patent number: 8759085
    Abstract: A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: June 24, 2014
    Assignee: Akonni Biosystems, Inc.
    Inventors: Phil Belgrader, Christopher G. Cooney, Robert Doebler, Anna Hickerson, Bruce Irvine, Ali Nadim, James Sterling, Reza Miraghaie
  • Publication number: 20140127773
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Application
    Filed: January 14, 2014
    Publication date: May 8, 2014
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Patent number: 8663974
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: March 4, 2014
    Assignee: Claremont BioSolutions LLC
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Patent number: 8603783
    Abstract: A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: December 10, 2013
    Assignee: Akonni Biosystems, Inc.
    Inventors: Phillip Belgrader, Christopher G. Cooney, Robert Doebler, Anna Hickerson, Bruce Irvine, Ali Nadim, James Sterling, Reza Miraghaie
  • Publication number: 20130090267
    Abstract: A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
    Type: Application
    Filed: August 1, 2012
    Publication date: April 11, 2013
    Inventors: Phillip BELGRADER, Christopher G. COONEY, Robert Doebler, Anna HICKERSON, Bruce IRVINE, Ali NADIM, James STERLING, Reza MIRAGHAIE
  • Patent number: D829339
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: September 25, 2018
    Assignee: CLAREMONT BIOSOLUTIONS LLC
    Inventors: Robert Doebler, Mark Brown, Bruce Irvine