Patents by Inventor Bruce J. Compton
Bruce J. Compton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9598716Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.Type: GrantFiled: November 8, 2013Date of Patent: March 21, 2017Assignee: Waters Technologies CorporationInventors: Edouard S. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying Q. Yu, Peter J. Lee, Elizabeth K. Kane
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Patent number: 9446330Abstract: A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.Type: GrantFiled: May 13, 2013Date of Patent: September 20, 2016Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Christopher C. Benevides, Robert Collamati, Bruce J. Compton, Theodore Dourdeville
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Publication number: 20140065651Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.Type: ApplicationFiled: November 8, 2013Publication date: March 6, 2014Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Edouard S. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying Q. Yu, Peter J. Lee, Elizabeth K. Brown
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Patent number: 8580533Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.Type: GrantFiled: May 30, 2003Date of Patent: November 12, 2013Assignee: Waters Technologies CorporationInventors: Edouard S. P. Bouvier, Bruce J. Compton, John C. Gebler, Martin Gilar, Ying-Qing Yu, Peter Jeng-Jong Lee, Elizabeth K. Brown
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Publication number: 20130248700Abstract: A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.Type: ApplicationFiled: May 13, 2013Publication date: September 26, 2013Inventors: Christopher C. Benevides, Robert Collamati, Bruce J. Compton, Theodore Dourdeville
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Patent number: 8496818Abstract: A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.Type: GrantFiled: October 7, 2004Date of Patent: July 30, 2013Assignee: Waters Technologies CorporationInventors: Christopher C. Benevides, Robert Albert Collamati, Bruce J. Compton, Theodore Dourdeville
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Patent number: 7564027Abstract: The present invention provides a device, system, and associated methods to actively or passively sample air by directing it onto the surface of a porous light-absorbing semiconductor, for example, a desorption/ionization on porous silicon (“DIOS”) chip. Upon adsorption of an analyte, the surface may be analyzed directly by laser desorption/ionization time-of-flight mass spectrometry. Because the process of laser desorption/ionization and subsequent mass detection does not require elevated temperatures, thermal degradation of analytes is avoided.Type: GrantFiled: February 9, 2004Date of Patent: July 21, 2009Assignee: Waters Investments LimitedInventors: Jeffrey W. Finch, Chris L. Stumpf, Bruce J. Compton
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Publication number: 20080197078Abstract: A high pressure liquid chromatography (HPLC) capillary column device, system and method for processing a HPLC sample with a cartridge housing a packed capillary column; at least one inlet connection to the capillary column for a sample fluid; and at least one outlet connection from the capillary column for the sample fluid. The outlet connection is able to accommodate either a spray tip for atomizing the sample fluid or a transport tube for transporting the sample fluid from a spray tip column to a spray tip. Inlet connections enable supply of electrical power to the capillary column through electrical connections disposed within the cartridge housing; and gas for evaporating the sample liquid is supplied to at least one outlet connection from the capillary column for the sample fluid through a gas supply line within the cartridge housing. The temperature of the sample liquid can be controlled through a heat connection.Type: ApplicationFiled: October 7, 2004Publication date: August 21, 2008Applicant: Waters Investments LimitedInventors: Christopher C. Benevides, Robert Albert Collamati, Bruce J. Compton, Theodore Dourdeville
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Patent number: 7311502Abstract: A method for supplying solvent to an ultra-high pressure liquid chromatography system using a hydraulic amplifier. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.Type: GrantFiled: March 1, 2004Date of Patent: December 25, 2007Assignee: Waters Investments LimitedInventors: Geoff C. Gerhardt, Bruce J. Compton
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Patent number: 7229539Abstract: Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group which enables the surfactant to be broken down under acidic conditions. The invention also includes methods of making anionic surfactants and methods of using anionic surfactants in a variety of applications.Type: GrantFiled: May 12, 2000Date of Patent: June 12, 2007Assignee: Waters Investments LimitedInventors: Peter Jeng Jong Lee, Bruce J. Compton
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Patent number: 7053366Abstract: A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an absorbent layer, wherein the absorbent layer retains selected molecules on the receiving surface. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.Type: GrantFiled: May 24, 2002Date of Patent: May 30, 2006Assignee: Waters Investments LimitedInventors: Edouard S. P. Bouvier, Bruce J. Compton, Dominic O. Gostick, Jeffery Mark Brown
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Patent number: 6958148Abstract: Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing at least two contiguous linked lysines or at least three contiguous linked glutamines.Type: GrantFiled: July 21, 2000Date of Patent: October 25, 2005Assignee: Pericor Science, Inc.Inventors: Howard Green, Bruce J. Compton, George D. Corey, Philippe Djian
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Publication number: 20040170510Abstract: A method for supplying solvent to an ultra-high pressure liquid chromatography system using a hydraulic amplifier. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.Type: ApplicationFiled: March 1, 2004Publication date: September 2, 2004Inventors: Geoff C. Gerhardt, Bruce J. Compton
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Patent number: 6712587Abstract: A hydraulic amplifier system for an ultra-high pressure liquid chromatography system. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.Type: GrantFiled: December 21, 2001Date of Patent: March 30, 2004Assignee: Waters Investments LimitedInventors: Geoff C. Gerhardt, Bruce J. Compton
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Publication number: 20030118459Abstract: A hydraulic amplifier system for an ultra-high pressure liquid chromatography system. The hydraulic amplifier system includes a hydraulic cylinder comprising a primary piston chamber in which a primary piston is disposed and a secondary piston chamber in which a secondary piston is disposed. The cross-sectional area of the primary piston is larger than the cross-sectional area of the secondary piston. The difference in the cross-sectional areas of the pistons creates an amplification of the pressure in the primary piston chamber and a reduction in flow rate.Type: ApplicationFiled: December 21, 2001Publication date: June 26, 2003Inventors: Geoff C. Gerhardt, Bruce J. Compton
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Patent number: 6267957Abstract: Methods, products and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the linking molecule contains at least two contiguous linked glutamines or at least three contiguous linked lysines. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule. A complementary linking molecule rich in lysines may be first attached to the tissue in the presence of transglutaminase, and then covalently bonded to a glutamine-containing linking molecule of the conjugate in the presence of transglutaminase.Type: GrantFiled: January 20, 1999Date of Patent: July 31, 2001Inventors: Howard Green, George D. Corey, Bruce J. Compton, Philippe Dijan
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Patent number: 4755195Abstract: A method of continuously degassifying water includes the steps of continuously introducing helium gas into a vessel forming a substantially vertically disposed chamber therewithin at an upper portion thereof; continuously directing upwardly a spray of fine water droplets formed from undegassed water continuously introduced into said chamber at a lower portion thereof; permitting said fine water droplets to intimately contact said helium gas to displace gases contained in said water droplets to provide degassed water in accordance with Dalton's Law of Partial Pressures, said degassed water proceeding towards a bottommost portion of said chamber and vessel; and continuously directing said degassed water through an outlet at said bottommost portion of said vessel into a device desirous of using said continuous flow degassed water.Type: GrantFiled: April 16, 1987Date of Patent: July 5, 1988Assignee: Pennwalt CorporationInventors: Bruce J. Compton, Robert W. Giering
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Patent number: 4594902Abstract: Discrete robotic sampling apparatus for withdrawing samples of pharmaceutical formulations having particulates therein contained within a plurality of dissolution vessels. The apparatus employs a single sampling probe utilizing a single in-line filter therein. Movement of the probe is guided by a robotic arm controlled by a programmable microprocessor which also controls a reversible pump for flushing the particulates retained by the filter, by means of filtered sample, back into the dissolution vessel, prior to dispensing a portion of the filtered sample into a sample container. The probe is then programmed to be washed with a wash solution prior to inserting of the probe into another dissolution vessel for withdrawing of sample therefrom.Type: GrantFiled: August 23, 1985Date of Patent: June 17, 1986Assignee: Pennwalt CorporationInventors: Bruce J. Compton, Orville N. Hinsvark