Patents by Inventor Bruce P. Bean

Bruce P. Bean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOCICEPTOR NEURONS CONTROL CANCER IMMUNOSURVEILLANCE
    Publication number: 20230165812
    Abstract: The present disclosure provides methods of treating cancer by silencing tumor-innervating sensory neurons. The methods include treating cancer by genetic ablation of ion channels (e.g., TRPV1 or NaV1.8), local pharmacological silencing or blockade of neuropeptide release from tumor-innervating nociceptor (e.g., with QX-314 and BoNT/a), as well as the antagonism of the CGRP receptor RAMP1 (e.g., with BIBN 4096).
    Type: Application
    Filed: February 26, 2021
    Publication date: June 1, 2023
    Applicants: President and Fellows of Harvard College, Université de Montréal, Children's Medical Center Corporation
    Inventors: Clifford J. Woolf, Sebastien Talbot, Bruce P. Bean
  • METHODS OF TREATING MUSCLE CRAMPING AND RELATED COMPOSITIONS
    Publication number: 20220387539
    Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
    Type: Application
    Filed: January 10, 2022
    Publication date: December 8, 2022
    Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
    Publication number: 20220041552
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: October 25, 2021
    Publication date: February 10, 2022
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, David P. Roberson, Sebastien Talbot
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20220016046
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment or neurogenic inflammation.
    Type: Application
    Filed: September 17, 2021
    Publication date: January 20, 2022
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20210290561
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Application
    Filed: June 2, 2021
    Publication date: September 23, 2021
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS
    Publication number: 20210186906
    Abstract: The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
    Type: Application
    Filed: April 17, 2020
    Publication date: June 24, 2021
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf
  • Charged ion channel blockers and methods for use
    Patent number: 11021443
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: June 1, 2021
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, David Roberson, Sebastien Talbot
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20210030695
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Application
    Filed: March 9, 2020
    Publication date: February 4, 2021
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
    Publication number: 20200377459
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: March 10, 2020
    Publication date: December 3, 2020
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, David P. Roberson, Sebastien Talbot
  • METHODS OF TREATING MUSCLE CRAMPING AND RELATED COMPOSITIONS
    Publication number: 20200375925
    Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
    Type: Application
    Filed: December 26, 2019
    Publication date: December 3, 2020
    Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
  • Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
    Patent number: 10729664
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: August 4, 2020
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Clifford J. Woolf, Bruce P. Bean
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE THEREOF
    Publication number: 20200231545
    Abstract: The invention provides compounds, compositions, methods and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: January 3, 2020
    Publication date: July 23, 2020
    Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf, Jinbo Lee, Sooyeon Jo, Ivan Tochitsky
  • Methods of treating muscle cramping and related compositions
    Patent number: 10568853
    Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: February 25, 2020
    Assignee: Cliff-Cartwright Corporation
    Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
  • PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20190216747
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.
    Type: Application
    Filed: December 11, 2018
    Publication date: July 18, 2019
    Inventors: Clifford J. WOOLF, Bruce P. BEAN
  • Methods, compositions, and kits for treating pain and pruritis
    Patent number: 10179116
    Abstract: The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: January 15, 2019
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf
  • CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
    Publication number: 20180237392
    Abstract: The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
    Type: Application
    Filed: August 3, 2016
    Publication date: August 23, 2018
    Inventors: Bruce P. BEAN, Clifford J. WOOLF, Jinbo LEE, Sooyeon JO, David ROBERSON, Sebastien TALBOT
  • Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise
    Patent number: 9937135
    Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: April 10, 2018
    Assignee: Flex Pharma, Inc.
    Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
  • METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS
    Publication number: 20170319517
    Abstract: The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
    Type: Application
    Filed: July 27, 2017
    Publication date: November 9, 2017
    Inventors: Bruce P. BEAN, Clifford J. Woolf
  • Methods, compositions, and kits for treating pain and pruritis
    Patent number: 9603817
    Abstract: The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: March 28, 2017
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: Bruce P. Bean, Clifford J. Woolf
  • METHODS OF TREATING MUSCLE CRAMPING AND RELATED COMPOSITIONS
    Publication number: 20160367506
    Abstract: Described herein are compositions comprising capsaicin and methods of treating muscle cramping in a subject, comprising orally administering to the subject a composition comprising capsaicin and an excipient.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 22, 2016
    Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon