Patents by Inventor Bruce R. Bistrian

Bruce R. Bistrian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5278149
    Abstract: A method of preparing TPN solutions, which is particularly well adaptable to computerized control, has been developed. These methods can assist the pharmacist or physician in the preparation of three-in-one TPN solutions containing lipid, dextrose and amino acids. The method includes a series of criteria for concentrations of lipid, dextrose, amino acids, and ions as well as eliminating the possibility of certain deleterious interactions.
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: January 11, 1994
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Pamela S. Provost, David F. Driscoll, Bruce R. Bistrian
  • Patent number: 5114401
    Abstract: Disclosed are an apparatus and methods for initial, or replacement, central venous catherization using a flexible guidewire with markings thereon and a substantially translucent non-thrombogenic catheter. In operation, the guidewire is inserted along a catheter positioned in a vein. The marks on the guidewire are then used to establish, and maintain as constant, the position of the guidewire. Next, the catheter already in the vein is removed by sliding it over the guidewire, and a new catheter is slipped over the guidewire into position. Once the new catheter is positioned, the guidewire is removed.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: May 19, 1992
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Regina K. Stuart, Jeffrey A. Lowell, John K. Baxter, III, Bruce R. Bistrian, Scott Shikora
  • Patent number: 5081105
    Abstract: Disclosed is a method of treating cancer using nutritional support therapy by administration of a structured lipid containing both .omega.3 fatty acids and medium-chain fatty acids. The therapy may be used as total parenteral nutrition or as a nutritional supplement. The addition of tumor necrosis factor may also be beneficial.
    Type: Grant
    Filed: January 25, 1990
    Date of Patent: January 14, 1992
    Assignee: New England Deaconess Hospital Corporation
    Inventor: Bruce R. Bistrian
  • Patent number: 4962094
    Abstract: Compositions useful in the treatment of dietary disorders, and as dietary additives to provide a source of fiber, of short chain fatty acids and as bulking agents in humans and animals, as well as methods of use therefor. The compositions are based on whole .beta.-glucans.
    Type: Grant
    Filed: October 28, 1988
    Date of Patent: October 9, 1990
    Assignee: Alpha Beta Technology, Inc.
    Inventors: Spiros Jamas, D. Davidson Easson, Jr., Bruce R. Bistrian
  • Patent number: 4952606
    Abstract: The present invention features a transesterification product of a mixture of fatty acids and triglycerides which include dairy fat as a primary component. This composition shows unexpected benefits in nutritional applications either as a food or as an enteral or parenteral supplement. The method of nutritional support using this composition is also disclosed.
    Type: Grant
    Filed: April 5, 1988
    Date of Patent: August 28, 1990
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Vigen K. Babayan, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4906664
    Abstract: A method of treating cancer cachexia syndrome has been discovered. Total parenteral nutrition using structured lipids in place of long chain fatty acids as the primary lipid source provides improvements in nitrogens balance, plasma serum albumin levels, and glucose clearance rate.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: March 6, 1990
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Bruce R. Bistrian, Vigen R. Babayan, George L. Blackburn
  • Patent number: 4871768
    Abstract: A new dietary supplement has been developed which yields the benefits of both .omega.3 oils and medium chain triglycerides for lipid nutrition. A structured lipid containing .omega.3 fatty acids and medium chain fatty acids is also disclosed.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: October 3, 1989
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Bruce R. Bistrian, Vigen K. Babayan, George L. Blackburn, Edward A. Mascioli
  • Patent number: 4847296
    Abstract: Chemically synthesized structured triglycerides (lipids) for enteral administration as the lipid calorie source, is subjects undergoing severe metabolic stress.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: July 11, 1989
    Inventors: Vigen K. Babayan, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4820731
    Abstract: Disclosed is a method of minimizing infection and minimizing the risks of infection in at risk animals and patients. A dietary supplement to accomplish this objective is also disclosed. The method includes the step of administering a diet rich in .omega.3 fatty acids, for example by adding a substantial proportion of fish oils to the diet. The dietary supplement is particularly well suited to patients receiving total parenteral nutrition. A parenteral diet or diet supplement containing a mixture of oils, one rich in .omega.3 fatty acids and the other rich in .omega.6 fatty acids is disclosed.
    Type: Grant
    Filed: June 15, 1988
    Date of Patent: April 11, 1989
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Edward A. Mascioli, George L. Blackburn, Bruce R. Bistrian, Vigen K. Babayan
  • Patent number: 4810726
    Abstract: A method of treating, and a diet composition for treating patients needing a controlled diet, wherein C.sub.12 fatty acids are the primary fatty acid source. Preferably lauric fats constitute 33-80% of the diet, while LCT's constitute no more than 20%. The lauric fats may be derived from a natural or fractionated kernel oil, selected from a group consisting of babassu oil, coconut oil, cohune oil, palm kernel oil, and tucum oil. A lipid emulsion with diverse additives is described.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: March 7, 1989
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Bruce R. Bistrian, Vigen K. Babayan, George L. Blackburn
  • Patent number: 4752618
    Abstract: Disclosed is a method of minimizing infection and minimizing the risks of infection in at risk animals and patients. A dietary supplement to accomplish this objective is also disclosed. The method includes the step of administering a diet rich in .omega.3 fatty acids, for example by adding a substantial proportion of fish oils to the diet. The dietary supplement is particularly well suited to patients receiving total parenteral nutrition.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: June 21, 1988
    Assignee: New England Deaconess Hospital
    Inventors: Edward A. Mascioli, George L. Blackburn, Bruce R. Bistrian, Vigen K. Babayan
  • Patent number: 4542017
    Abstract: Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are infected with bacteria, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during infection, and thereby promote the normal metabolic response by the human.
    Type: Grant
    Filed: December 9, 1982
    Date of Patent: September 17, 1985
    Inventors: Lyle L. Moldawer, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4512974
    Abstract: Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are to undergo surgery, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during surgery, and thereby promote the normal metabolic response by the human (patient).
    Type: Grant
    Filed: December 8, 1982
    Date of Patent: April 23, 1985
    Inventors: Lyle L. Moldawer, George L. Blackburn, Bruce R. Bistrian