Patents by Inventor Bruce Rosen
Bruce Rosen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11872022Abstract: An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.Type: GrantFiled: February 18, 2019Date of Patent: January 16, 2024Assignees: The General Hospital Corporation, Massachusetts Institute of TechnologyInventors: Maria Angela Franceschini, Stefan Carp, Davide Tamborini, David Boas, Bruce Rosen, Megan Blackwell, Oleg Shatrovoy
-
Patent number: 11511113Abstract: Techniques are disclosed related to increasing prior limits imposed on MR gradient switching speed (dB/dt) without causing significant discomfort or severe pain perception to patients. The technique disclosed herein do so by modifying the pulsing gradient fields that are ordinarily available for MR imaging protocols. Doing so stimulates the peripheral nerves and thus enables a quick, reversible, and complete inhibition of action potential propagation through the stimulated region of tissue, referred to as a nerve conduction block.Type: GrantFiled: August 16, 2019Date of Patent: November 29, 2022Assignees: Siemens Healthcare GmbH, The General Hospital CorporationInventors: Stefan Popescu, Lawrence Wald, Bruce Rosen, Jason Stockmann
-
Publication number: 20220183561Abstract: An imaging-based biomarker that indicates a neurological state of a subject is generated from magnetic resonance imaging data acquired from the subject while the subject was sleeping, or during both a sleep state and wake state. These magnetic resonance imaging data are acquired in such a way so that they simultaneously enable measurement of cerebrospinal fluid (“CSF”) flow and blood-oxygenation-level dependent (“BOLD”) signals. The imaging-based biomarker can be generated based on a correlation between CSF signals and BOLD signals extracted from these magnetic resonance imaging data. Using electroencephalography (“EEG”) data, CSF flow dynamics can also be estimated based on a physiological model in which coherent neural activity is modeled as entraining oscillations in blood volume and CSF.Type: ApplicationFiled: April 13, 2020Publication date: June 16, 2022Inventors: Laura Lewis, Bruce Rosen, Jonathan R. Polimeni
-
Publication number: 20210046315Abstract: Techniques are disclosed related to increasing prior limits imposed on MR gradient switching speed (dB/dt) without causing significant discomfort or severe pain perception to patients. The technique disclosed herein do so by modifying the pulsing gradient fields that are ordinarily available for MR imaging protocols. Doing so stimulates the peripheral nerves and thus enables a quick, reversible, and complete inhibition of action potential propagation through the stimulated region of tissue, referred to as a nerve conduction block.Type: ApplicationFiled: August 16, 2019Publication date: February 18, 2021Applicants: Siemens Healthcare GmbH, The General Hospital CorporationInventors: Stefan Popescu, Lawrence Wald, Bruce Rosen, Jason Stockmann
-
Publication number: 20200375476Abstract: An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.Type: ApplicationFiled: February 18, 2019Publication date: December 3, 2020Inventors: Maria Angela Franceschini, Stefan Carp, Davide Tamborini, David Boas, Bruce Rosen, Megan Blackwell, Oleg Shatrovoy
-
Patent number: 10661091Abstract: Systems and methods for designing parallel transmission radiofrequency (RF) pulses for use in a RF treatment. The methods include selecting a target region in a subject, and providing a plurality of specific absorption rate (SAR) matrices for estimation of SAR at locations within the subject. The methods also include determining a first set of SAR matrices for locations in the target region using the provided SAR matrices, and determining a second set of SAR matrices for locations not in the target region using the provided SAR matrices. The methods further include designing a plurality of RF pulses for achieving a target power deposition in the target region by using the first set of SAR matrices and the second set of SAR matrices in an optimization that determines a set of RF waveforms that produce a target average local SAR using the first set of SAR matrices while minimizing a local SAR and a global SAR using the second set of SAR matrices.Type: GrantFiled: March 25, 2015Date of Patent: May 26, 2020Assignee: The General Hospital CorporationInventors: Bastien Guerin, Lawrence L. Wald, Bruce Rosen
-
Patent number: 10012709Abstract: A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator are configured to provide a rotating frame preparation pulse sequence comprising at least one of, (a) a T1 spin lattice relaxation in a rotating frame (T1?) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection and (b) a T2 spin-spin relaxation in a rotating frame (T2?) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection.Type: GrantFiled: August 5, 2013Date of Patent: July 3, 2018Assignees: The General Hospital Corporation, Siemens Healthcare GmbHInventors: Ovidiu Andronesi, Bruce Rosen, Peter Caravan, Himanshu Bhat
-
Publication number: 20150273230Abstract: Systems and methods for designing parallel transmission radiofrequency (RF) pulses for use in a RF treatment. The methods include selecting a target region in a subject, and providing a plurality of specific absorption rate (SAR) matrices for estimation of SAR at locations within the subject. The methods also include determining a first set of SAR matrices for locations in the target region using the provided SAR matrices, and determining a second set of SAR matrices for locations not in the target region using the provided SAR matrices. The methods further include designing a plurality of RF pulses for achieving a target power deposition in the target region by using the first set of SAR matrices and the second set of SAR matrices in an optimization that determines a set of RF waveforms that produce a target average local SAR using the first set of SAR matrices while minimizing a local SAR and a global SAR using the second set of SAR matrices.Type: ApplicationFiled: March 25, 2015Publication date: October 1, 2015Inventors: Bastien Guerin, Lawrence L. Wald, Bruce Rosen
-
Patent number: 8944985Abstract: An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.Type: GrantFiled: April 3, 2009Date of Patent: February 3, 2015Assignee: The General Hospital CorporationInventors: Giorgio Bonmassar, Matti S. Hamalainen, Bruce Rosen
-
Publication number: 20140035580Abstract: A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition.Type: ApplicationFiled: August 5, 2013Publication date: February 6, 2014Inventors: Ovidiu Andronesi, Bruce Rosen, Peter Caravan, Himanshu Bhat
-
Publication number: 20090254146Abstract: An implant for deep brain stimulation (DBS) has an array of electromagnetic microcoils dispersed over the length of the implant. The microcoils produce magnetic fields that are directed into, and induce current in, the adjacent brain tissue. The microcoils may be selectively operated to direct and focus electrical stimulation to targeted areas of the brain. The implant is useful in studying or treating neurophysiological conditions associated with the deep regions of the brain such as Parkinson's disease, drug addiction, and depression.Type: ApplicationFiled: April 3, 2009Publication date: October 8, 2009Inventors: Giorgio Bonmassar, Matti S. Hamalainen, Bruce Rosen
-
Patent number: 7478588Abstract: The present invention is directed to baking apparatuses that are adapted for use in baking cakes, custards and other dishes that involve the use of a water bath. In a disclosed embodiment of the invention a baking apparatus is disclosed that includes an inner and outer pan, which may be formed as an integral unit. The outer pan is preferably adapted to receive and hold water and the inner pan is adapted to receive a springform containing a cheesecake batter or other mixture. The side or sides of the inner pan are preferably watertight and prevent leakage of water into the inner pan. The present invention offers the advantage of water bath baking without the problem of water from the bath leaking into the springform that contains the cake batter.Type: GrantFiled: April 2, 2004Date of Patent: January 20, 2009Inventors: Robert J. Miller, Bruce Rosen
-
Publication number: 20070081945Abstract: This invention relates to novel magnetic resonance imaging contrast agents, and methods of making and use thereof.Type: ApplicationFiled: May 8, 2006Publication date: April 12, 2007Inventors: Megan Blackwell, Bruce Rosen, Christian Farrar, Wellington Pham
-
Publication number: 20060217264Abstract: A catalyst composition and its use for the oxidation of ethane to ethylene and acetic acid which comprises (i) a support, and (ii) in combination with oxygen, the elements molybdenum, vanadium and niobium, optionally tungsten and a component Z, which is one or more metals of Group 14 of the Periodic Table of Elements; a, b, c, d and e represent the gram atom ratios of the elements Mo, W, Z, V and Nb respectively, such that 0<a?1; 0?b<1 and a+b=1; 0.05<c?2; 0<d?2; and 0<e?1.Type: ApplicationFiled: July 30, 2004Publication date: September 28, 2006Inventors: James Brazdil, Richard George, Bruce Rosen
-
Publication number: 20060128988Abstract: An oxide catalyst composition comprising the elements molybdenum, vanadium, niobium and titanium and a process for making the catalyst composition. A process for the selective oxidation of ethane and/or ethylene and/or ethylene to acetic acid using the catalyst composition. The catalyst composition provides high selectivity to acetic acid with reduced selectivity to ethylene.Type: ApplicationFiled: April 28, 2004Publication date: June 15, 2006Inventors: James Brazdil, Richard George, Bruce Rosen
-
Publication number: 20060052635Abstract: The present invention provides a method of preparation of a supported catalyst composition suitable for the oxidation of ethane to ethylene and/or acetic acid, and/or the oxidation of ethylene to acetic acid, which supported catalyst composition comprises a catalyst, comprising one or more metal components, on a support comprising alpha-alumina, and which method comprises (a) forming a slurry comprising the one or more metal components, and alpha-alumina support particles or an alpha-alumina support precursor, (b) spray-drying the slurry, and, optionally, (c) calcining the spray-dried slurry to form the supported catalyst composition. The present invention also provides a supported catalyst composition formed by the above method, and a process for the selective oxidation of ethane to ethylene and/or acetic acid, and/or the selective oxidation of ethylene to acetic acid utilising the supported catalyst composition.Type: ApplicationFiled: December 11, 2003Publication date: March 9, 2006Inventor: Bruce Rosen
-
Publication number: 20050217498Abstract: The present invention is directed to baking apparatuses that are adapted for use in baking cakes, custards and other dishes that involve the use of a water bath. In a disclosed embodiment of the invention a baking apparatus is disclosed that includes an inner and outer pan, which may be formed as an integral unit. The outer pan is preferably adapted to receive and hold water and the inner pan is adapted to receive a springform containing a cheesecake batter or other mixture. The side or sides of the inner pan are preferably watertight and prevent leakage of water into the inner pan. The present invention offers the advantage of water bath baking without the problem of water from the bath leaking into the springform that contains the cake batter.Type: ApplicationFiled: April 2, 2004Publication date: October 6, 2005Inventors: Robert Miller, Bruce Rosen
-
Publication number: 20050095587Abstract: The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce anitbodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.Type: ApplicationFiled: February 21, 2001Publication date: May 5, 2005Inventors: Scott Panzer, Peter Shapiro, Steven Banville, Purvi Shah, Michael Chalup, Simon Chang, Alice Chen, Steven D'sa, Stefan Amshey, Christopher Dahl, Tam Dam, Susan Daniels, Gerard Dufour, Vincent Flores, Willy Fong, Lila Greenawalt, Jennifer Jackson, Anissa Jones, Tommy Liu, Ann Roseberry Lincoln, Bruce Rosen, Frank Russo, Theresa Stockdreher, Abel Daffo, Rachel Wright, Pierre Yap, Jimmy Yu, Diana Bradley, Shawn Bratcher, Wensheng Chen, Howard Cohen, David Hodgson, Stephen Lincoln, Stuart Jackson