Patents by Inventor Bruce S Edwards

Bruce S Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for binding to ER?/? and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof
    Patent number: 7875721
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ER? and ER?). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: January 25, 2011
    Assignee: STC.UNM
    Inventors: Eric R. Prossnitz, Sergey E. Tkatchenko, Chetana M. Revankar, Larry A. Sklar, Jeffrey B. Arterburn, Daniel F. Cimino, Tudor I. Oprea, Cristian-George Bologa, Bruce S. Edwards, Alexander Kiselyov, Susan M. Young
  • Flow cytometry for high throughput screening
    Patent number: 7842244
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: November 30, 2010
    Assignee: STC.UNM
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck
  • Compounds and methods for the selective inhibition of ABCB1, ABCC1 and ABCG2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors
    Publication number: 20090208493
    Abstract: Compounds disclosed which inhibit ABCB1 transporter protein are useful for treating diseases in which ABCB1 transporter protein mediates the disease state, including numerous cancers, including hematopoietic cancers, including various leukemias, especially T-lineage acute lymphoblastic leukemia, as well as cancerous tumors, especially forms which exhibit multiple drug resistance. Pharmaceutical compositions which comprise an inhibitor of ABCB1 transporter protein and at least one additional anticancer agent, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient are another aspect of the present invention. A flow cytometry based, high-throughput screening (HST) assay that quantifies ABCB1 efflux is also disclosed. Methods of identifying inhibitors of ABCB1, ABCG2 and ABCC1 transporter proteins are also disclosed.
    Type: Application
    Filed: November 28, 2008
    Publication date: August 20, 2009
    Applicant: STC. UNM
    Inventors: Richard S. Larson, Larry A. Sklar, Bruce S. Edwards, Irena D. Ivnitski-Steele, Tudor I. Oprea, Debbie M. Lovato, Hadya M. Khawaja, Stuart S. Winter, Susan M. Young
  • Flow cytometry for high throughput screening
    Publication number: 20080292500
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Application
    Filed: May 5, 2008
    Publication date: November 27, 2008
    Applicant: STC.UNM
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck
  • Compounds for binding to ERalpha/beta and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof
    Publication number: 20080167334
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ER? and ER?). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors.
    Type: Application
    Filed: August 2, 2006
    Publication date: July 10, 2008
    Inventors: Eric R. Prossnitz, Sergey E. Tkatchenko, Chetana M. Revankar, Larry A. Sklar, Jeffrey B. Arterburn, Daniel F. Cimino, Tudor I. Oprea, Cristian-George Bologa, Bruce S. Edwards, Alexander Kiselyov, Susan M. Young
  • Flow cytometry for high throughput screening
    Patent number: 7368084
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: May 6, 2008
    Assignee: STC.UNM
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck
  • Flow cytometry for high throughput screening
    Patent number: 6890487
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Grant
    Filed: February 10, 2000
    Date of Patent: May 10, 2005
    Assignee: Science & Technology Corporation ©UNM
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck
  • Flow cytometry for high throughput screening
    Patent number: 6878556
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: April 12, 2005
    Assignee: Science & Technology Corporation @ UNM
    Inventors: Larry A Sklar, Bruce S Edwards, Frederick W Kuckuck
  • Plug flow cytometry for high throughput screening and drug discovery
    Patent number: 6638481
    Abstract: An apparatus for drawing and supplying multiple samples for rapid processing in flow cytometry. The apparatus comprises a reciprocating valve and at least one syringe. The invention is also a method for rapidly processing multiple samples in flow cytometry using the apparatus.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: October 28, 2003
    Assignee: Science and Technology Corporation @ UNM
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck, III
  • Microfluidic micromixer
    Publication number: 20030040105
    Abstract: A mixing apparatus is provided comprising: first driving means for driving a plurality of reagent samples from a plurality of respective source wells into a first fluid flow stream; second driving means for introducing a separation gas between each of the plurality of reagent samples in the first fluid flow stream; means for driving a second fluid flow stream comprising a plurality of particles; a junction device comprising: a first inlet port for receiving the first fluid flow stream; a second inlet port for receiving the second fluid flow stream; a reaction zone for forcing mixing between the first fluid flow stream and the second fluid flow stream to thereby form a reaction product stream; and an outlet port for allowing the reaction product stream to exit the junction device; a reaction zone where the plurality of reagent samples and the plurality of particles mix to form a plurality of reaction products, the reaction zone communicating with the outlet port; reaction product driving means for driving the
    Type: Application
    Filed: December 19, 2001
    Publication date: February 27, 2003
    Inventors: Larry A. Sklar, Tione Buranda, Bruce S. Edwards, Carlos M. Gallegos, W. Coyt Jackson, Frederick W. Kuckuck, Gabriel P. Lopez, Andrea A. Mammoli
  • Flow cytometry for high throughput screening
    Publication number: 20030013201
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Application
    Filed: August 9, 2002
    Publication date: January 16, 2003
    Inventors: Larry A Sklar, Bruce S Edwards, Frederick W. Kuckuck
  • Flow cytometry for high throughput screening
    Publication number: 20020170365
    Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
    Type: Application
    Filed: July 12, 2002
    Publication date: November 21, 2002
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck
  • Plug flow cytometry for high throughput screening and drug discovery
    Publication number: 20020015664
    Abstract: An apparatus for drawing and supplying multiple samples for rapid processing in flow cytometry. The apparatus comprises a reciprocating valve and at least one syringe. The invention is also a method for rapidly processing multiple samples in flow cytometry using the apparatus.
    Type: Application
    Filed: September 19, 2001
    Publication date: February 7, 2002
    Inventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck