Patents by Inventor Bruce Trapnell

Bruce Trapnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and methods for treatment of lung disorders characterized by cholesterol dysregulation
    Patent number: 10251852
    Abstract: Disclosed are compositions and methods for treating a condition characterized by a dysregulation in macrophage lipid homeostasis. The disclosed methods may include the administration of an agent selected from a PPAR? agonist, a LXR agonist, or a combination thereof. In certain aspects, the disclosed methods may be used to prevent, treat, or ameliorate conditions such as pulmonary alveolar proteinosis (PAP) and/or symptoms associated therewith.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: April 9, 2019
    Assignee: Children's Hospital Medical Center
    Inventors: Bruce Trapnell, Tony Sallese, Brenna Carey, Takuji Suzuki
  • COMPOSITIONS AND METHODS FOR TREATMENT OF LUNG DISORDERS CHARACTERIZED BY CHOLESTEROL DYSREGULATION
    Publication number: 20180000758
    Abstract: Disclosed are compositions and methods for treating a condition characterized by a dysregulation in macrophage lipid homeostasis. The disclosed methods may include the administration of an agent selected from a PPAR? agonist, a LXR agonist, or a combination thereof. In certain aspects, the disclosed methods may be used to prevent, treat, or ameliorate conditions such as pulmonary alveolar proteinosis (PAP) and/or symptoms associated therewith.
    Type: Application
    Filed: April 11, 2017
    Publication date: January 4, 2018
    Inventors: Bruce Trapnell, Tony Sallese, Brenna Carey, Takuji Suzuki
  • Method for creating myeloid cell lines
    Publication number: 20070059830
    Abstract: The methods and compositions of the present invention find use in modulating myeloid cell development, particularly differentiation and proliferation. The compositions of the invention include isolated transgenic cells, transgenic tissue, transgenic animals, and transgenic mice. The methods allow generation of myeloid cell lines suitable for tissue culture. Further the invention provides methods of modulating immune disorders, particularly myeloid disorders, more particularly leukemias.
    Type: Application
    Filed: August 24, 2006
    Publication date: March 15, 2007
    Inventors: Bruce Trapnell, Pierre-Yves Berclaz