Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: The invention provides a solution for secure and non-manipulatable processing of a data stream in a receiver, possibly in conjunction with a smartcard. A packet identity and a content type identifier associated with the packet identifier are received in encrypted form and securely processed within the receiver to allow an encrypted payload of the data stream to be processed without the possibility to manipulate the content type identifier in an attempt to intercept the payload after decryption.

Abstract: The invention provides a solution for secure and non-manipulatable processing of a data stream in a receiver, possibly in conjunction with a smartcard. A packet identity and a content type identifier associated with the packet identifier are received in encrypted form and securely processed within the receiver to allow an encrypted payload of the data stream to be processed without the possibility to manipulate the content type identifier in an attempt to intercept the payload after decryption.

Abstract: The invention relates to an electronic device configured for encrypted data transfer with a smart card under a trust key. The electronic device comprises at least one secured portion, wherein the electronic device is configured for performing a key exchange algorithm with the smart card for establishing the trust key for the encrypted data transfer between the electronic device and the smart card and wherein the electronic device is configured for storing the trust key in the secured portion of the electronic device.

Abstract: The present invention is a male anatomical enhancement garment to enhance male genitalia with a base, a penis, a scrotum and testicles and a penis head that includes a base band to receive the genitalia that wraps around the base of the genitalia to secure the garment in place, a penis sheath to receive the penis that expands and contracts as the penis expands and contracts and a frontal aperture disposed on the end of the penis sheath that the inserted penis is inserted through. The garment also includes an internally embedded silicon polymer bead or attached elasticized band that is positioned behind the penis head after the penis is received through the front aperture and a pouch that contains the scrotum and testicles. There is also a glans cover that is provided to cover the penis head as well in another embodiment.

Abstract: The invention provides a solution for secure and non-manipulatable processing of a data stream in a receiver, possibly in conjunction with a smartcard. A packet identity and a content type identifier associated with the packet identifier are received in encrypted form and securely processed within the receiver to allow an encrypted payload of the data stream to be processed without the possibility to manipulate the content type identifier in an attempt to intercept the payload after decryption.

Abstract: An improved plunger lift apparatus having an internal orifice, nozzles and exit apertures. The present invention relates to an improved plunger lift apparatus for the lifting of formation liquids in a hydrocarbon well. More specifically the improved plunger consists of a plunger apparatus that operates to propel one or more jets of gas through one or more internal orifices and/or nozzles, out through an aperture and into the liquid load formation, thereby providing a momentum transfer of the gas into the liquid load and causing a gaseous and turbulent aeration to the formation during lift. This action allows a large liquid formation load to be carried to the well top by the plunger at an increased level of efficiency resulting in an improved well productivity level.

Abstract: An improved plunger mechanism apparatus has an internal shock absorber to increase plunger life and increases life of components found at a top and well bottom. The internal shock absorber can be an elastomer spring, die coil spring or wave spring. An actuator rod within the plunger hits the bottom of the well and compresses the internal spring, absorbing all or part of the impact shock. Likewise, when a plunger rises to the well top with a high velocity, damage is avoided as the top of the plunger hits well top apparatus. Reduction in well bottom bumper spring collapses, spring damage, and plunger damage is obtained. Damage to well bottoms having no bumper springs is avoided. Efficiency of well flow is increased by the increase in the reliability of the well operation.

Abstract: An improved bypass plunger mechanism apparatus has one or more internal shock absorbing elements within a captive actuator, a fixed or variable bypass valve, and a hallow mandrel to improve reliability and well flow production levels in high liquid wells. Energy due to impact shock resulting from the plunger hitting the top or the bottom of the well is absorbed by one or more internal shock absorber elements. Efficiency of well flow is increased by the addition of a variable bypass orifice, which can be preset in numerous positions to vary the amount of liquid bypass allowed depending on the well loading parameters. The plunger mechanism of the present invention increases well efficiency by reducing failure due to damage in the well top, well bottom and plunger apparatus.

Abstract: An improved plunger mechanism apparatus has a manually adjustable bypass valve to increase well flow production levels in high liquid wells. The plunger's descent rate can be fine tuned in the field by adjusting the orifice opening so that liquid can optimally flow through the plunger core during descent. Efficiency of well flow is increased by the addition of a variable bypass orifice, which can be preset in numerous positions to vary the amount of liquid bypass allowed depending on the well loading parameters. The plunger mechanism of the present invention allows numerous bypass set positions, which can be tuned at a well site and later changed as a function of future well loading parametric changes.

Abstract: An improved plunger mechanism apparatus to increase well flow production levels in sand based wells. Efficiency of well flow is increased by the addition of radial peripheral holes extending from a hallowed out center core to outer peripheral grooves enabling a self-cleaning action which will prevent sand from accumulating on the outer surface of the plunger, allow the plunger to force fall back to the well bottom, and carry sand out of the well bottom. The self-cleaning sand plunger keeps the well clean, removes unwanted sand, self cleans and significantly reduces maintenance time in a sand based gas well.